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Antipsychotics - Po...
Antipsychotics - Postmortem fatal and non-fatal reference concentrations
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- Söderberg, Carl (författare)
- Karolinska Institutet,Linköping University,Karolinska Institute, Sweden; National Board Forens Med, Department Forens Med, Artillerigatan 12, S-58758 Linkoping, Sweden
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- Wernvik, Emma (författare)
- Linköping University,National Board Forens Med, Department Forens Med, Artillerigatan 12, S-58758 Linkoping, Sweden
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- Tillmar, Andreas (författare)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,National Board Forens Med, Department Forens Genet and Forens Chemistry, Artillerigatan 12, S-58758 Linkoping, Sweden
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- Spigset, Olav (författare)
- St Olavs University Hospital, Norway; Norwegian University of Science and Technology, Norway
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- Kronstrand, Robert (författare)
- Linköpings universitet,Linköping University,Avdelningen för läkemedelsforskning,Medicinska fakulteten,National Board Forens Med, Department Forens Genet and Forens Chemistry, Artillerigatan 12, S-58758 Linkoping, Sweden
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- Reis, Margareta (författare)
- Linköpings universitet,Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden,Avdelningen för läkemedelsforskning
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- Jönsson, Anna K. (författare)
- Linköping University,National Board Forens Med, Department Forens Genet and Forens Chemistry, Artillerigatan 12, S-58758 Linkoping, Sweden
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- Druid, Henrik (författare)
- Karolinska Institutet,Linköping University,Karolinska Institute, Sweden; National Board Forens Med, Department Forens Med, Artillerigatan 12, S-58758 Linkoping, Sweden
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 11 s.
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 266, s. 91-101
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Making the diagnosis fatal intoxication is a challenging task for the forensic pathologist and toxicologist, particularly when the cases involve substances where reference information is scarce or not at all available. This study presents postmortem femoral blood concentrations for 24 antipsychotic substances, based on samples collected and analyzed from 4949 autopsy cases in Sweden during 1992-2010. In addition our study provides information about the prevalence of different antipsychotics in accidental, suicidal, homicidal and uncertain deaths.The data have been selected and evaluated according to strict inclusion and exclusion criteria as well as a manual, multi-reviewer, case-by-case evaluation. The reference information is subdivided into intoxications by one specific substance only (group A, n = 259), multi-substance intoxications (group B, n = 614) and postmortem controls, consisting of deaths not involving incapacitation by substances (group C, n = 507). Moreover, the results are compared with data based on therapeutic drug monitoring, and data collected from driving under the influence cases.Median concentrations in group A were significantly higher than in group C for all substances evaluated. For 17 of 24 substances, the median concentrations in group B were significantly higher than in group C. In general, the therapeutic drug monitoring and driving under the influence concentrations were similar to, or lower than, the concentrations in group C.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Rättsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Forensic Science (hsv//eng)
Nyckelord
- Antipsychotics
- Blood
- Forensic toxicology
- Intoxication
- Postmortem
- Antipsychotics; Forensic toxicology; Intoxication; Postmortem; Blood
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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