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Sökning: onr:"swepub:oai:DiVA.org:uu-510343" > Field Synopsis of E...

Field Synopsis of Environmental and Genetic Risk Factors of Sporadic Early-Onset Colorectal Cancer and Advanced Adenoma

Zhang, Rongqi (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Boakye, Daniel (författare)
Univ West Scotland, Sch Hlth & Life Sci, Glasgow, Scotland.
Yang, Nan (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
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Zhou, Xuan (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland.
Zhou, Yajing (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Jiang, Fangyuan (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Yu, Lili (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Wang, Lijuan (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland.
Sun, Jing (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Yuan, Shuai (författare)
Karolinska Institutet
Chen, Jie (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.
Hamilton, Ashleigh C. (författare)
Queens Univ Belfast, Ctr Publ Hlth, Belfast, North Ireland.
Coleman, Helen G. (författare)
Queens Univ Belfast, Ctr Publ Hlth, Belfast, North Ireland.;Northern Ireland Canc Registry, Belfast, North Ireland.
Larsson, Susanna C. (författare)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
Little, Julian (författare)
Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
Dunlop, Malcolm G. (författare)
Univ Edinburgh, Med Res Council, Canc Res UK Edinburgh Ctr, Inst Genet & Canc, Edinburgh, Scotland.
Giovannucci, Edward L. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
Theodoratou, Evropi (författare)
Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland.;Univ Edinburgh, Med Res Council, Canc Res UK Edinburgh Ctr, Inst Genet & Canc, Edinburgh, Scotland.
Li, Xue (författare)
Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China.;Zhejiang Univ, Sch Med, Sch Publ Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China.
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Zhejiang Univ Sch Med, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci,Sch Publ Hlth,Key Lab Intel, Hangzhou, Peoples R China Univ West Scotland, Sch Hlth & Life Sci, Glasgow, Scotland. (creator_code:org_t)
American Association For Cancer Research (AACR), 2023
2023
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 32:8, s. 1048-1060
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: To systematically appraise and synthesize avail-able epidemiologic evidence on the associations of environmental and genetic factors with the risk of sporadic early-onset colorectal cancer (EOCRC) and early-onset advanced colorectal adenoma (EOCRA).Methods: Multiple databases were comprehensively searched to identify eligible observational studies. Genotype data from UK Biobank were incorporated to examine their associations with EOCRC in a nested case-control design. Meta-analyses of envi-ronmental risk factors were performed, and the strength of evidence was graded based on predefined criteria. Meta-analyses of genetic associations were conducted using the allelic, recessive, and dom-inant models, respectively.Results: A total of 61 studies were included, reporting 120 environmental factors and 62 genetic variants. We found 12 risk factors (current overweight, overweight in adolescence, high waist circumference, smoking, alcohol, sugary beverages intake, seden-tary behavior, red meat intake, family history of colorectal cancer, hypertension, hyperlipidemia, and metabolic syndrome) and three protective factors (vitamin D, folate, and calcium intake) for EOCRC or EOCRA. No significant associations between the exam-ined genetic variants and EOCRC risk were observed.Conclusions: Recent data indicate that the changing patterns of traditional colorectal cancer risk factors may explain the rising incidence of EOCRC. However, research on novel risk factors for EOCRC is limited; therefore, we cannot rule out the possibility of EOCRC having different risk factors than late-onset colorectal cancer (LOCRC).Impact: The potential for the identified risk factors to enhance the identification of at-risk groups for personalized EOCRC screen-ing and prevention and for the prediction of EOCRC risk should be comprehensively addressed by future studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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