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Small baseline volu...
Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia. The Göteborg MCI study.
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- Eckerström, Carl (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Neuroscience and Physiology, Göteborg University, Sweden
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- Olsson, Erik, 1960 (author)
- Gothenburg University,Göteborgs universitet,Filosofiska institutionen,Institutionen för biomedicin,Department of Philosophy,Institute of Biomedicine,Department of Philosophy, Göteborg University, Sweden, Institute of Biomedicine, Göteborg University, Sweden
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- Borga, Magnus (author)
- Linköpings universitet,Tekniska högskolan,Medicinsk informatik,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Ekholm, Sven (author)
- Department of Radiology, University of Rochester Medical Center, United States
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- Ribbelin, Susanne (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Radiology, Göteborg University, Sweden
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- Rolstad, Sindre, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Neuroscience and Physiology, Göteborg University, Sweden
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- Starck, Göran (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,Department of Radiology, Göteborg University, Sweden, Department of Radiation Physics, Göteborg University, Sweden
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- Edman, Åke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Edman, Å., Institute of Neuroscience and Physiology, Göteborg University, Sweden
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Neuroscience and Physiology, Göteborg University, Sweden
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- Malmgren, Helge, 1945 (author)
- Gothenburg University,Göteborgs universitet,Filosofiska institutionen,Department of Philosophy,Department of Philosophy, Göteborg University, Sweden
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Journal of the Neurological Sciences. - : Elsevier BV. - 0022-510X .- 1878-5883. ; 272:1-2, s. 48-59
- Related links:
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Abstract
Subject headings
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- Background: Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss. Objective: To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampal volume to different forms of dementia, and to investigate the role of hippocampal side differences and rate of volume loss over time. Patients: The subjects (N = 68) include patients with MCI at baseline and progression to dementia at the two-year follow-up (N = 21), stable MCI patients (N = 21), and controls (N = 26). Among the progressing patients, 13 were diagnosed as having AD. Methods: The Göteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually on the MRI investigations at baseline and at the two-year follow-up. Results: Hippocampal volumetry could predict conversion to dementia in both the AD and the non-AD subgroup of converters. Left hippocampal volume in particular discriminated between converting and stable MCI. Cut off points for individual discrimination were shown to be potentially useful. The converting MCI group had a significantly higher rate of hippocampal volume loss as compared to the stable MCI group. Conclusions: In MCI patients, hippocampal volumetry at baseline gives prognostic information about possible development of AD and non-AD dementia. Contrary to earlier studies, we found that left hippocampal volume has the best predictive power. Reliable predictions appear to be possible in many individual cases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Dementia
- Alzheimer's disease
- Vascular dementia
- Mild cognitive impairment (MCI)
- Volumetric MRI
- Hippocampus
- Brain asymmetries
- Alzheimer's disease
- TECHNOLOGY
Publication and Content Type
- ref (subject category)
- art (subject category)
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Eckerström, Carl
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Olsson, Erik, 19 ...
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Borga, Magnus
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Ekholm, Sven
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Ribbelin, Susann ...
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Rolstad, Sindre, ...
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Starck, Göran
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Edman, Åke
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Wallin, Anders, ...
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Malmgren, Helge, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Journal of the N ...
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University of Gothenburg
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Linköping University