Clustering of individuals with both breast and ovarian cancer--a possible indicator of BRCA founder mutations.

• In a cohort of 60436 women with a diagnosis of invasive breast carcinoma and known to reside in Sweden in 1960, 321 had a subsequent diagnosis of ovarian carcinoma. Assuming no correlation between the two cancers, one would expect that 191 women would develop ovarian cancer (standardized incidence ratio (SIR) 1.7; 95% confidence interval 1.5-1.9). Women with breast cancer before 40 years of age were at highest risk for developing ovarian cancer (SIR 4.5). Between 40 and 49 years of age, the SIR was 1.9, and at 50 years of age or older, the SIR was 1.3. Most of the excess in ovarian cancer occurred in southern Sweden. The geographic distribution of these cases coincided with the distribution of families with known BRCA1 and BRCA2 gene mutations. These results suggest that genetic factors account for the excess in ovarian cancer that occurs in breast cancer patients and that geographic clustering of patients who have both breast and ovarian cancer may indicate the presence of a BRCA founder mutation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adenocarcinoma

epidemiology

genetics

Adolescent

Adult

Aged

BRCA1 Protein

genetics

BRCA2 Protein

genetics

Breast Neoplasms

epidemiology

genetics

Child

Cluster Analysis

Female

Genetic Predisposition to Disease

Geography

Germ-Line Mutation

Humans

Middle Aged

Mutation

Ovarian Neoplasms

epidemiology

genetics

Prevalence

Registries

Risk Factors

Sweden

epidemiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)