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A meta-analysis of ...
A meta-analysis of prior corticosteroid use and fracture risk.
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Kanis, John A (författare)
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- Johansson, Helena, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg
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- Odén, Anders, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Johnell, Olof (författare)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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De Laet, Chris (författare)
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Melton III, L Joseph (författare)
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Tenenhouse, Alan (författare)
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Reeve, Jonathan (författare)
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Silman, Alan J (författare)
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Pols, Huibert A P (författare)
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Eisman, John A (författare)
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McCloskey, Eugene V (författare)
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- Mellström, Dan, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine,University of Gothenburg
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(creator_code:org_t)
- 2004
- 2004
- Engelska.
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Ingår i: Journal of bone and mineral research. - 0884-0431 .- 1523-4681. ; 19:6, s. 893-9
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The relationship between use of corticosteroids and fracture risk was estimated in a meta-analysis of data from seven cohort studies of approximately 42,000 men and women. Current and past use of corticosteroids was an important predictor of fracture risk that was independent of prior fracture and BMD. INTRODUCTION: The aims of this study were to validate that corticosteroid use is a significant risk factor for fracture in an international setting and to explore the effects of age and sex on this risk. MATERIALS AND METHODS: We studied 42,500 men and women from seven prospectively studied cohorts followed for 176,000 patient-years. The cohorts comprised the EPOS/EVOS study, CaMos, the Rotterdam Study, Dubbo Osteoporosis Epidemiology Study (DOES), and prospective cohorts at Sheffield, Rochester, and Gothenburg. The effect of ever use of corticosteroids, BMD, age, and sex on all fracture, osteoporotic fracture, and hip fracture risk alone was examined using Poisson regression in each cohort and for each sex. The results of the different studies were merged from the weighted beta coefficients. RESULTS: Previous corticosteroid use was associated with a significantly increased risk of any fracture, osteoporotic fracture, and hip fracture when adjusted for BMD. Relative risk of any fracture ranged from 1.98 at the age of 50 years to 1.66 at the age of 85 years. For osteoporotic fracture, the range of relative risk was 2.63-1.71, and for hip fracture 4.42-2.48. The estimate of relative risk was higher at younger ages, but not significantly so. No significant difference in risk was seen between men and women. The risk was marginally and not significantly upwardly adjusted when BMD was excluded from the model. The risk was independent of prior fracture. In the three cohorts that documented current corticosteroid use, BMD was significantly reduced at the femoral neck, but fracture risk was still only partly explained by BMD. CONCLUSION: We conclude that prior and current exposure to corticosteroids confers an increased risk of fracture that is of substantial importance beyond that explained by the measurement of BMD. Its identification on an international basis validates the use of this risk factor in case-finding strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Adrenal Cortex Hormones
- administration & dosage
- Aged
- Female
- Fractures
- Bone
- chemically induced
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Humans
- corticosteroids
- fracture risk
- fracture threshold
- meta-analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kanis, John A
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Johansson, Helen ...
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Odén, Anders, 19 ...
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Johnell, Olof
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De Laet, Chris
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Melton III, L Jo ...
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visa fler...
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Tenenhouse, Alan
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Reeve, Jonathan
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Silman, Alan J
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Pols, Huibert A ...
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Eisman, John A
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McCloskey, Eugen ...
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Mellström, Dan, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Fysiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Journal of bone ...
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola
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Lunds universitet