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Performance of non-...
Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
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- Mozes, Ferenc E. (författare)
- Univ Oxford, England
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- Lee, Jenny A. (författare)
- Univ Amsterdam, Netherlands
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- Vali, Yasaman (författare)
- Univ Amsterdam, Netherlands
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- Alzoubi, Osama (författare)
- Univ Jordan, Jordan
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- Staufer, Katharina (författare)
- Med Univ Vienna, Austria; Med Univ Vienna, Austria
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- Trauner, Michael (författare)
- Med Univ Vienna, Austria
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- Paternostro, Rafael (författare)
- Med Univ Vienna, Austria
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- Stauber, Rudolf E. (författare)
- Med Univ Graz, Austria
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- Holleboom, Adriaan G. (författare)
- Univ Amsterdam, Netherlands
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- van Dijk, Anne-Marieke (författare)
- Univ Amsterdam, Netherlands
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- Mak, Anne Linde (författare)
- Univ Amsterdam, Netherlands
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- Boursier, Jerome (författare)
- Univ Angers, France; Ctr Hosp Univ Angers, France
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- Loup, Marc de Saint (författare)
- Ctr Hosp Univ Angers, France
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- Shima, Toshihide (författare)
- Saiseikai Suita Hosp, Japan
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- Bugianesi, Elisabetta (författare)
- Univ Turin, Italy
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- Gaia, Silvia (författare)
- Univ Turin, Italy
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- Armandi, Angelo (författare)
- Univ Turin, Italy
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- Lupsor-Platon, Monica (författare)
- Iuliu Haieganu Univ Med & Pharm, Romania
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- Wong, Vincent Wai-Sun (författare)
- Chinese Univ Hong Kong, Peoples R China
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- Li, Guanlin (författare)
- Chinese Univ Hong Kong, Peoples R China
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- Wong, Grace Lai-Hung (författare)
- Chinese Univ Hong Kong, Peoples R China
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- Cobbold, Jeremy (författare)
- Univ Oxford, England
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- Karlas, Thomas (författare)
- Univ Hosp Leipzig, Germany
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- Wiegand, Johannes (författare)
- Univ Hosp Leipzig, Germany
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- Sebastiani, Giada (författare)
- McGill Univ, Canada; McGill Univ, Canada
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- Tsochatzis, Emmanuel (författare)
- Royal Free London NHS Fdn Trust, England; UCL, England
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- Liguori, Antonio (författare)
- Royal Free London NHS Fdn Trust, England; UCL, England; Univ Cattol Sacro Cuore, Italy
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- Yoneda, Masato (författare)
- Yokohama City Univ, Japan
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- Nakajima, Atsushi (författare)
- Yokohama City Univ, Japan
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- Hagstrom, Hannes (författare)
- Karolinska Institutet
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- Akbari, Camilla (författare)
- Dept Med, Sweden
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- Hirooka, Masashi (författare)
- Ehime Univ, Japan
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- Chan, Wah-Kheong (författare)
- Univ Malaya, Malaysia
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- Mahadeva, Sanjiv (författare)
- Univ Malaya, Malaysia
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- Rajaram, Ruveena (författare)
- Univ Malaya, Malaysia
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- Zheng, Ming-Hua (författare)
- Wenzhou Med Univ, Peoples R China; Wenzhou Med Univ, Peoples R China; Key Lab Diag & Treatment Dev Chron Liver Dis Zhej, Peoples R China
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- George, Jacob (författare)
- Univ Sydney, Australia
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- Eslam, Mohammed (författare)
- Univ Sydney, Australia
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- Petta, Salvatore (författare)
- PROMISE, Italy
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- Pennisi, Grazia (författare)
- PROMISE, Italy
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- Vigano, Mauro (författare)
- ASST Papa Giovanni XXIII, Italy
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- Ridolfo, Sofia (författare)
- Univ Milan, Italy
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- Aithal, Guruprasad Padur (författare)
- Univ Nottingham, England
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- Palaniyappan, Naaventhan (författare)
- Univ Nottingham, England
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- Lee, Dae Ho (författare)
- Gachon Univ, South Korea
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- Ekstedt, Mattias (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Nasr, Patrik (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Cassinotto, Christophe (författare)
- Univ Hosp Montpellier, France; Univ Hosp Montpellier, France
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- de Ledinghen, Victor (författare)
- Bordeaux Univ Hosp, France; Univ Bordeaux, France
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- Berzigotti, Annalisa (författare)
- Univ Hosp Bern, Switzerland; Univ Bern, Switzerland
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- Mendoza, Yuly P. (författare)
- Univ Bern, Switzerland
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- Noureddin, Mazen (författare)
- Houston Methodist Hosp, TX USA
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- Truong, Emily (författare)
- Cedars Sinai Med Ctr, CA USA
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- Fournier-Poizat, Celine (författare)
- Echosens, France
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- Geier, Andreas (författare)
- Univ Hosp Wurzburg, Germany
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- Martic, Miljen (författare)
- Novartis Inst Biomed Res, Switzerland
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- Tuthill, Theresa (författare)
- Pfizer, MA USA
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- Anstee, Quentin M. (författare)
- Newcastle Univ, Australia; Newcastle Tyne Hosp NHS Trust, Australia
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- Harrison, Stephen A. (författare)
- Univ Oxford, England
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- Bossuyt, Patrick M. (författare)
- Univ Amsterdam, Netherlands
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- Pavlides, Michael (författare)
- Univ Oxford, England
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(creator_code:org_t)
- ELSEVIER INC, 2023
- 2023
- Engelska.
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Ingår i: The Lancet Gastroenterology & Hepatology. - : ELSEVIER INC. - 2468-1253. ; 8:8, s. 704-713
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare the prognostic performance of non-invasive tests with liver histology in patients with NAFLD. Methods This was an individual participant data meta-analysis of the prognostic performance of histologically assessed fibrosis stage (F0-4), liver stiffness measured by vibration-controlled transient elastography (LSM-VCTE), fibrosis-4 index (FIB-4), and NAFLD fibrosis score (NFS) in patients with NAFLD. The literature was searched for a previously published systematic review on the diagnostic accuracy of imaging and simple non-invasive tests and updated to Jan 12, 2022 for this study. Studies were identified through PubMed/MEDLINE, EMBASE, and CENTRAL, and authors were contacted for individual participant data, including outcome data, with a minimum of 12 months of follow-up. The primary outcome was a composite endpoint of all-cause mortality, hepatocellular carcinoma, liver transplantation, or cirrhosis complications (ie, ascites, variceal bleeding, hepatic encephalopathy, or progression to a MELD score >= 15). We calculated aggregated survival curves for trichotomised groups and compared them using stratified log-rank tests (histology: F0-2 vs F3 vs F4; LSM: <10 vs 10 to <20 vs >= 20 kPa; FIB-4: <1<middle dot>3 vs 1<middle dot>3 to <= 2<middle dot>67 vs >2<middle dot>67; NFS: <-1<middle dot>455 vs -1<middle dot>455 to <= 0<middle dot>676 vs >0<middle dot>676), calculated areas under the time-dependent receiver operating characteristic curves (tAUC), and performed Cox proportional-hazards regression to adjust for confounding. This study was registered with PROSPERO, CRD42022312226.Findings Of 65 eligible studies, we included data on 2518 patients with biopsy-proven NAFLD from 25 studies (1126 [44<middle dot>7%] were female, median age was 54 years [IQR 44-63), and 1161 [46<middle dot>1%] had type 2 diabetes). After a median follow-up of 57 months [IQR 33-91], the composite endpoint was observed in 145 (5<middle dot>8%) patients. Stratified log-rank tests showed significant differences between the trichotomised patient groups (p<0<middle dot>0001 for all comparisons). The tAUC at 5 years were 0<middle dot>72 (95% CI 0<middle dot>62-0<middle dot>81) for histology, 0<middle dot>76 (0<middle dot>70-0<middle dot>83) for LSM-VCTE, 0<middle dot>74 (0<middle dot>64-0<middle dot>82) for FIB-4, and 0<middle dot>70 (0<middle dot>63-0<middle dot>80) for NFS. All index tests were significant predictors of the primary outcome after adjustment for confounders in the Cox regression.Interpretation Simple non-invasive tests performed as well as histologically assessed fibrosis in predicting clinical outcomes in patients with NAFLD and could be considered as alternatives to liver biopsy in some cases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Mozes, Ferenc E.
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Lee, Jenny A.
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Vali, Yasaman
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Alzoubi, Osama
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Staufer, Kathari ...
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Trauner, Michael
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Paternostro, Raf ...
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Stauber, Rudolf ...
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Holleboom, Adria ...
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van Dijk, Anne-M ...
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Mak, Anne Linde
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Boursier, Jerome
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Loup, Marc de Sa ...
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Shima, Toshihide
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Bugianesi, Elisa ...
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Gaia, Silvia
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Armandi, Angelo
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Lupsor-Platon, M ...
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Wong, Vincent Wa ...
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Li, Guanlin
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Wong, Grace Lai- ...
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Cobbold, Jeremy
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Karlas, Thomas
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Wiegand, Johanne ...
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Sebastiani, Giad ...
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Tsochatzis, Emma ...
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Liguori, Antonio
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Yoneda, Masato
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Nakajima, Atsush ...
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Hagstrom, Hannes
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Akbari, Camilla
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Hirooka, Masashi
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Chan, Wah-Kheong
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Mahadeva, Sanjiv
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Rajaram, Ruveena
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Zheng, Ming-Hua
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George, Jacob
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Eslam, Mohammed
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Petta, Salvatore
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Pennisi, Grazia
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Vigano, Mauro
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Ridolfo, Sofia
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Aithal, Gurupras ...
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Palaniyappan, Na ...
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Lee, Dae Ho
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Ekstedt, Mattias
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Nasr, Patrik
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Cassinotto, Chri ...
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de Ledinghen, Vi ...
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Berzigotti, Anna ...
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Mendoza, Yuly P.
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Noureddin, Mazen
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Truong, Emily
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Fournier-Poizat, ...
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Geier, Andreas
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Martic, Miljen
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Tuthill, Theresa
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Anstee, Quentin ...
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Harrison, Stephe ...
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Bossuyt, Patrick ...
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Pavlides, Michae ...
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Linköpings universitet
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