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Genotype-covariate interaction effects and the heritability of adult body mass index

Cesarini, David (author)
Center for Experimental Social Science,NYU, Dept Econ, Ctr Expt Social Sci, 550 1St Ave, New York, NY 10003 USA.
Johannesson, Magnus (author)
Stockholm School of Economics,Handelshögskolan i Stockholm,Stockholm Sch Econ, Stockholm, Sweden.
Ingelsson, Erik, 1975- (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.,Karolinska Institutet (SE)
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Magnusson, Patrik K. E. (author)
Karolinska Institutet,Karolinska Institutet (SE)
Pedersen, Nancy L. (author)
Karolinska Institutet,Karolinska Institutet (SE)
Esko, Tõnu (author)
University of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.;Boston Childrens Hosp, Div Endocrinol, Cambridge, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.
Yang, Jian (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Visscher, Peter M. (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Robinson, Matthew R. (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland.
English, G. (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Moser, G. (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Lloyd-Jones, LR (author)
University of Queensland (AU),Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Triplett, MA (author)
University of Queensland (AU),Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia.,University of Tartu
Zhu, Z. (author)
University of Queensland,Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
Nolte, IM (author)
University of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands.
van Vliet-Ostaptchouk, JV (author)
University of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands.;Univ Groningen, Dept Endocrinol, Univ Med Ctr Groningen, Groningen, Netherlands.
Snieder, H (author)
University of Groningen (NL),Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands.
Milani, Lili (author)
University of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.
Mägi, Reedik (author)
University of Tartu,Univ Tartu, Estonia Genome Ctr, Tartu, Estonia.
Metspalu, Andres (author)
University of Tartu
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Center for Experimental Social Science NYU, Dept Econ, Ctr Expt Social Sci, 550 1St Ave, New York, NY 10003 USA (creator_code:org_t)
 
2017-07-10
2017
English.
In: Nature Genetics. - : Nature Research (part of Springer Nature). - 1061-4036 .- 1546-1718. ; 49:8, s. 1174-1181
Related links:
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10-18), which contributed 8.1% (1.4% s.e.) to BMI variation. Across eight self-reported lifestyle factors, including diet and exercise, we find genotype-environment interaction only for smoking behavior (LRT = 19.70, P = 5.03 × 10-5 and LRT = 30.80, P = 1.42 × 10-8), which contributed 4.0% (0.8% s.e.) to BMI variation. Bayesian association analysis suggests that BMI is highly polygenic, with 75% of the SNP heritability attributable to loci that each explain <0.01% of the phenotypic variance. Our findings imply that substantially larger sample sizes across ages and lifestyles are required to understand the full genetic architecture of BMI.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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