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Modelling of magnet...
Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes – a pre-clinical study
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- Sjöstrand, Sandra (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Bacou, Marion (författare)
- University of Edinburgh
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- Kaczmarek, Katarzyna (författare)
- University of Strathclyde
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- Evertsson, Maria (författare)
- Lund University,Lunds universitet,Medicinsk teknik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicinskt ultraljud,Forskargrupper vid Lunds universitet,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Biomedical Engineering, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Medical ultrasound,Lund University Research Groups,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH
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- Svensson, Ingrid K. (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Avancerade ljuskällor,LTH profilområden,LTH profilområde: Teknik för hälsa,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: Engineering Health,Faculty of Engineering, LTH
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- Thomson, Adrian Jw (författare)
- University of Edinburgh
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- Farrington, Susan M. (författare)
- University of Edinburgh
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- Moug, Susan J. (författare)
- University of Glasgow
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- Jansson, Tomas (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Medicinskt ultraljud,Forskargrupper vid Lunds universitet,Medicon Bridge,LTH profilområde: Teknik för hälsa,LTH profilområden,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Medical ultrasound,Lund University Research Groups,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,University of Edinburgh
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- Moran, Carmel M. (författare)
- University of Edinburgh
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- Mulvana, Helen (författare)
- University of Strathclyde
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(creator_code:org_t)
- British Institute of Radiology, 2022
- 2022
- Engelska.
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Ingår i: British Journal of Radiology. - : British Institute of Radiology. - 0007-1285 .- 1748-880X. ; 95:1135
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objectives: Despite advances in MRI the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neoadjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterisation of cancer tissues. We report proof of concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interro-gate tissue mechanical properties through magnetically induced deformations. Methods: The feasibility of the proposed application was explored using a combination of experimental animal and phantom ultrasound imaging, along with finite element analysis. First, contrast-enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, tissue phantoms were imaged using MMUS to illustrate the force-and elasticity dependence of the magneto-motion. Third, the magnetomechanical interactions of a magnetic microbubble with an elastic solid were simu-lated using finite element software. Results: Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occur-ring 3.7 s post-injection. The magnetic microbubble gave rise to displacements depending on force, elasticity, and bubble radius, indicating an inverse relation between displacement and the latter two. Conclusion: Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Advances in knowledge: (a) Lymphatic drainage of magnetic microbubbles visualised using contrast-enhanced ultrasound imaging and (b) magnetomechan-ical interactions between such bubbles and surrounding tissue could both contribute to (c) robust detection and characterisation of lymph nodes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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Sjöstrand, Sandr ...
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Bacou, Marion
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Kaczmarek, Katar ...
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Evertsson, Maria
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Svensson, Ingrid ...
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Thomson, Adrian ...
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Farrington, Susa ...
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Moug, Susan J.
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Jansson, Tomas
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Moran, Carmel M.
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Mulvana, Helen
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