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Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
- Crowther-Swanepoel, Dalemari (author)
- Broderick, Peter (author)
- Di Bernardo, Maria Chiara (author)
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- Dobbins, Sara E. (author)
- Torres, Maria (author)
- Ruiz-Ponte, Clara (author)
- Enjuanes, Anna (author)
- Carracedo, Angel (author)
- Jurlander, Jesper (author)
- Campo, Elias (author)
- Montserrat, Emilio (author)
- Dyer, Martin J. S. (author)
- Matutes, Estella (author)
- Dearden, Claire (author)
- Sunter, Nicola J. (author)
- Hall, Andrew G. (author)
- Mainou-Fowler, Tryfonia (author)
- Jackson, Graham H. (author)
- Summerfield, Geoffrey (author)
- Harris, Robert J. (author)
- Pettitt, Andrew R. (author)
- Allsup, David J. (author)
- Bailey, James R. (author)
- Pratt, Guy (author)
- Pepper, Chris (author)
- Fegan, Chris (author)
- Parker, Anton (author)
- Oscier, David (author)
- Allan, James M. (author)
- Catovsky, Daniel (author)
- Houlston, Richard S. (author)
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- (creator_code:org_t)
- 2010-01-10
- 2010
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:2, s. 132-136
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
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- art (subject category)
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- Oscier, David
- Allan, James M.
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