Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

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Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

Magnussen, Christina (författare): Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

Ojeda, Francisco M. (författare): Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany

Leong, Darryl P. (författare): McMaster Univ, Dept Med Cardiol, Hamilton, ON, Canada

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Alegre-Diaz, Jesus (författare)

Amouyel, Philippe (författare): Univ Lille, INSERM, Ctr Hosp Univ Lille,Epidemiol & Public Hlth Dept, Inst Pasteur Lille,UMR1167 RID AGE Risk Factors &, Lille, France

Aviles-Santa, Larissa (författare): Natl Inst Minor Hlth & Hlth Dispar, Div Clin & Hlth Serv Res, NIH, Bethesda, MD USA

De Bacquer, Dirk (författare): Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium

Ballantyne, Christie M. (författare): Baylor Coll Med, Dept Med, Houston, TX USA

Bernabé-Ortiz, Antonio (författare): Univ Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Lima, Peru

Bobak, Martin (författare): UCL, Dept Epidemiol & Publ Hlth, London, England

Brenner, Hermann (författare): Heidelberg Univ, Network Aging Res, Heidelberg, Germany

Carrillo-Larco, Rodrigo M. (författare): Emory Univ, Rollins Sch Publ Hlth, Emory Global Diabet Res Ctr, Atlanta, GA USA;Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA

de Lemos, James (författare): Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA;Univ Nacl Autonoma Mexico, Expt Med Res Unit, Sch Med, Mexico City, DF, Mexico

Dobson, Annette (författare): Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia

Dörr, Marcus (författare): Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;Greifswald Medical School; DZHK Partner Site Greifswald, Greifswald, Germany

Donfrancesco, Chiara (författare): Ist Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Rome, Italy

Drygas, Wojciech (författare): Natl Inst Cardiol, Dept Epidemiol Cardiovasc Dis Prevent & Hlth Prom, Warsaw, Poland;Lazarski Univ, Warsaw, Poland

Dullaart, Robin P. (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands

Engström, Gunnar (författare): Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden

Ferrario, Marco M. (författare): Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy

Ferrières, Jean (författare): Toulouse Rangueil Univ Hosp, INSERM, UMR1295, Dept Cardiol, Toulouse, France

de Gaetano, Giovanni (författare): IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy

Goldbourt, Uri (författare): Tel Aviv Univ, Dept Epidemiol, Sch Publ Hlth, Tel Aviv, Israel

Gonzalez, Clicerio (författare): Inst Nacl Salud Publ, Ctr Estudios Diabet, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico

Grassi, Guido (författare): Univ Milano Bicocca, Med Clin, Milan, Italy

Hodge, Allison M. (författare): Canc Council Victoria, Div Canc Epidemiol, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

Hveem, Kristian (författare): Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, HUNT Trondelag Hlth Study Res Ctr, Levanger, Norway;KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

Iacoviello, Licia (författare): Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy;IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy

Ikram, M. Kamran (författare): Erasmus MC, Dept Neurol, Rotterdam, Netherlands;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Irazola, Vilma (författare): Inst Clin Effectiveness & Hlth Policy, Dept Chron Dis, Buenos Aires, DF, Argentina

Jobe, Modou (författare): London Sch Hyg & Trop Med, Med Res Council Unit Gambia, Banjul, Gambia

Jousilahti, Pekka (författare): Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

Kaleebu, Pontiano (författare): Uganda Virus Res Inst, Med Res Council, Entebbe, Uganda;London Sch Hyg & Trop Med, Uganda Res Unit, Entebbe, Uganda

Kavousi, Maryam (författare): Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Kee, Frank (författare): Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

Khalili, Davood (författare): Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran

Koenig, Wolfgang (författare): German Heart Ctr, DZHK Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Munich, Germany:Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany

Kontsevaya, Anna (författare): Minist Healthcare Russian Federat, Natl Res Ctr Therapy & Prevent Med, Moscow, Russia

Kuulasmaa, Kari (författare): Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland

Lackner, Karl J. (författare): Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany;DZHK Partner Site Rhine Main, Mainz, Germany

Leistner, David M. (författare): Univ Heart & Vasc Ctr Frankfurt, DZHK Partner Site Rhine Main, Frankfurt, Germany

Lind, Lars (författare): Uppsala universitet,Institutionen för medicinska vetenskaper

Linneberg, Allan (författare): Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark

Lorenz, Thiess (författare): Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

Lyngbakken, Magnus Nakrem (författare): Akershus Univ Hosp, Div Med, Dept Cardiol, Lorenskog, Norway;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Cardiac Biomarkers, Fac Med, Oslo, Norway

Malekzadeh, Reza (författare): Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Liver & Pancreaticobiliary Dis Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Oncol Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran

Malyutina, Sofia (författare): Russian Acad Sci, Res Inst Internal & Prevent Med, Branch Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia

Mathiesen, Ellisiv B. (författare): Arctic Univ Norway, Univ Tromso, Dept Clin Med, Tromso, Norway

Melander, Olle (författare): Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden

Metspalu, Andres (författare): Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia

Risérus, Ulf, 1967- (författare): Uppsala universitet,Klinisk nutrition och metabolism

Blankenberg, Stefan (författare): Univ Med Ctr Hamburg Eppendorf, Dept Cardiol, Univ Heart & Vasc Ctr, Ctr Populat Hlth Innovat, Martinistr 52, D-20246 Hamburg, Germany University of Hamburg;University Medical Center Hamburg-Eppendorf

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(creator_code:org_t)

Massachusetts Medical Society, 2023
2023
Engelska.
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 389:14, s. 1273-1285

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)Harmonized individual-level data from a global cohort showed that more than half the cases of incident cardiovascular disease and one fifth of deaths may be attributable to five modifiable risk factors.

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Av författaren/redakt...: Magnussen, Chris ...; Ojeda, Francisco ...; Leong, Darryl P.; Alegre-Diaz, Jes ...; Amouyel, Philipp ...; Aviles-Santa, La ...; visa fler...; De Bacquer, Dirk; Ballantyne, Chri ...; Bernabé-Ortiz, A ...; Bobak, Martin; Brenner, Hermann; Carrillo-Larco, ...; de Lemos, James; Dobson, Annette; Dörr, Marcus; Donfrancesco, Ch ...; Drygas, Wojciech; Dullaart, Robin ...; Engström, Gunnar; Ferrario, Marco ...; Ferrières, Jean; de Gaetano, Giov ...; Goldbourt, Uri; Gonzalez, Clicer ...; Grassi, Guido; Hodge, Allison M ...; Hveem, Kristian; Iacoviello, Lici ...; Ikram, M. Kamran; Irazola, Vilma; Jobe, Modou; Jousilahti, Pekk ...; Kaleebu, Pontian ...; Kavousi, Maryam; Kee, Frank; Khalili, Davood; Koenig, Wolfgang; Kontsevaya, Anna; Kuulasmaa, Kari; Lackner, Karl J.; Leistner, David ...; Lind, Lars; Linneberg, Allan; Lorenz, Thiess; Lyngbakken, Magn ...; Malekzadeh, Reza; Malyutina, Sofia; Mathiesen, Ellis ...; Melander, Olle; Metspalu, Andres; Risérus, Ulf, 19 ...; Blankenberg, Ste ...; visa färre...

Artiklar i publikationen: New England Jour ...

Av lärosätet: Uppsala universitet

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Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

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