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The complex genetic...
The complex genetics of gait speed : Genome-wide meta-analysis approach
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- Ben-Avraham, Dan (author)
- Yeshiva University
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- Karasik, David (author)
- Beth Israel Deaconess Medical Center,Bar-Ilan University
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- Verghese, Joe (author)
- Yeshiva University
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- Lunetta, Kathryn L (author)
- Boston University,National Heart Lung and Blood Institute
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- Smith, Jennifer A (author)
- University of Michigan
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- Eicher, John D. (author)
- National Heart Lung and Blood Institute
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- Vered, Rotem (author)
- University of Haifa
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- Deelen, Joris (author)
- Max Planck Institute for Biology of Ageing,Leiden University Medical Centre
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- Arnold, Alice M (author)
- University of Washington
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- Buchman, Aron S (author)
- Rush University Medical Center Chicago
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- Tanaka, Toshiko (author)
- National Institute on Aging, United States
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- Faul, Jessica D (author)
- University of Michigan
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- Nethander, Maria, 1980 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
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- Fornage, Myriam (author)
- University of Texas
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- Adams, Hieab H. (author)
- Erasmus University Medical Center
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- Matteini, Amy M. (author)
- Johns Hopkins University
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- Callisaya, Michele L. (author)
- Peninsula Health,University of Tasmania
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- Smith, Albert V (author)
- University of Iceland
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- Yu, Lei (author)
- Rush University Medical Center Chicago
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- De Jager, Philip L (author)
- Harvard University,Broad Institute,Brigham and Women's Hospital / Harvard Medical School
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- Evans, Denis A (author)
- Rush University Medical Center Chicago
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- Gudnason, Vilmundur (author)
- University of Iceland
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- Hofman, Albert (author)
- Erasmus University Medical Center,Harvard University
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- Pattie, Alison (author)
- University of Edinburgh
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- Corley, Janie (author)
- University of Edinburgh
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- Launer, Lenore J. (author)
- National Institute on Aging, United States
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- Knopman, Davis S. (author)
- Mayo Clinic Minnesota
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- Parimi, Neeta (author)
- California Pacific Medical Center
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- Turner, Stephen T. (author)
- Mayo Clinic Minnesota
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- Bandinelli, Stefania (author)
- Azienda Sanitaria Firenze (ASF)
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- Beekman, Marian (author)
- Leiden University Medical Centre
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- Gutman, Danielle (author)
- University of Haifa
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- Sharvit, Lital (author)
- University of Haifa
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- Mooijaart, Simon P (author)
- Leiden University Medical Centre
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- Liewald, David C M (author)
- University of Edinburgh
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- Houwing-Duistermaat, Jeanine J (author)
- University of Leeds,Leiden University Medical Centre
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Moed, Matthijs (author)
- Leiden University Medical Centre
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- Verlinden, Vincent J. (author)
- Erasmus University Medical Center
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- van der Geest, Jos N. (author)
- Erasmus University Medical Center
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups
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- Hernandez, Dena (author)
- National Institute on Aging, United States
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- McWhirter, Rebekah (author)
- University of Tasmania
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- Liu, Yongmei (author)
- Wake Forest University
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- Thomson, Russell (author)
- Western Sydney University,University of Tasmania
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- Tranah, Gregory J (author)
- California Pacific Medical Center
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- Uitterlinden, Andre G. (author)
- Erasmus University Medical Center
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- Weir, David R (author)
- University of Michigan
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- Zhao, Wei (author)
- University of Michigan
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- Starr, John M (author)
- University of Edinburgh
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- Johnson, Andrew D (author)
- National Heart Lung and Blood Institute
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- Arfan Ikram, M. (author)
- Erasmus University Medical Center
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- Bennett, David A (author)
- Rush University Medical Center Chicago
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- Cummings, Steven R (author)
- California Pacific Medical Center
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- Deary, Ian J (author)
- University of Edinburgh
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- Harris, Tamara B. (author)
- National Institute on Aging, United States
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- Kardia, Sharon L. (author)
- University of Michigan
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- Mosley, Thomas H. (author)
- University of Mississippi Medical Center
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- Srikanth, Velandai K. (author)
- Peninsula Health,University of Tasmania
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- Windham, Beverly G. (author)
- University of Mississippi Medical Center
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- Newman, Ann B. (author)
- University of Pittsburgh
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- Walston, Jeremy D. (author)
- Johns Hopkins University
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- Davies, Gail (author)
- University of Edinburgh
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- Evans, Daniel S (author)
- California Pacific Medical Center
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- Slagboom, P. Eline (author)
- Leiden University Medical Centre
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- Ferrucci, Luigi (author)
- National Institute on Aging, United States
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- Kiel, Douglas P (author)
- Beth Israel Deaconess Medical Center,Broad Institute
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- Murabito, Joanne M. (author)
- National Heart Lung and Blood Institute,Boston University
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- Atzmon, Gil (author)
- University of Haifa,Yeshiva University
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(creator_code:org_t)
- 2017-01-10
- 2017
- English 38 s.
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In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 9:1, s. 209-246
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues. The meta-analysis resulted in a list of 536 suggestive genome wide significant SNPs in or near 69 genes. Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks. Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the meta-analysis and pathway suggested that genetic effects on gait speed may occur through synaptic function and neuronal development pathways. No genome-wide significant signals for gait speed were identified from this moderately large sample of older adults, suggesting that more refined physical function phenotypes will be needed to identify the genetic basis of gait speed in aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Aging
- Gait speed
- GWAS
- Meta-analysis
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
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Aging
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Ben-Avraham, Dan
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Karasik, David
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Verghese, Joe
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Lunetta, Kathryn ...
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Smith, Jennifer ...
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Eicher, John D.
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show more...
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Vered, Rotem
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Deelen, Joris
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Arnold, Alice M
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Buchman, Aron S
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Tanaka, Toshiko
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Faul, Jessica D
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Nethander, Maria ...
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Fornage, Myriam
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Adams, Hieab H.
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Matteini, Amy M.
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Callisaya, Miche ...
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Smith, Albert V
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Yu, Lei
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De Jager, Philip ...
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Evans, Denis A
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Gudnason, Vilmun ...
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Hofman, Albert
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Pattie, Alison
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Corley, Janie
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Launer, Lenore J ...
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Knopman, Davis S ...
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Parimi, Neeta
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Turner, Stephen ...
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Bandinelli, Stef ...
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Beekman, Marian
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Gutman, Danielle
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Sharvit, Lital
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Mooijaart, Simon ...
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Liewald, David C ...
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Houwing-Duisterm ...
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Ohlsson, Claes, ...
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Moed, Matthijs
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Verlinden, Vince ...
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Mellström, Dan, ...
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van der Geest, J ...
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Karlsson, Magnus
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Hernandez, Dena
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McWhirter, Rebek ...
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Liu, Yongmei
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Thomson, Russell
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Tranah, Gregory ...
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Uitterlinden, An ...
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Weir, David R
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Zhao, Wei
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Starr, John M
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Johnson, Andrew ...
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Arfan Ikram, M.
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Bennett, David A
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Cummings, Steven ...
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Deary, Ian J
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Harris, Tamara B ...
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Kardia, Sharon L ...
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Mosley, Thomas H ...
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Srikanth, Veland ...
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Windham, Beverly ...
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Newman, Ann B.
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Walston, Jeremy ...
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Davies, Gail
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Evans, Daniel S
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Slagboom, P. Eli ...
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Ferrucci, Luigi
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Kiel, Douglas P
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Murabito, Joanne ...
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Atzmon, Gil
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Aging
- By the university
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Lund University
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University of Gothenburg