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Genome-wide interac...
Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma
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- Chattopadhyay, Subhayan (author)
- German Cancer Research Centre,Heidelberg University
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- Thomsen, Hauke (author)
- German Cancer Research Centre
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- Yadav, Pankaj (author)
- German Cancer Research Centre
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- da Silva Filho, Miguel Inacio (author)
- German Cancer Research Centre
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- Weinhold, Niels (author)
- University of Arkansas,University Hospital Heidelberg
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- Nöthen, Markus M (author)
- University of Bonn
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- Hoffman, Per (author)
- University of Bonn,University of Basel
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- Bertsch, Uta (author)
- University Hospital Heidelberg
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- Huhn, Stefanie (author)
- University Hospital Heidelberg
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- Morgan, Gareth J (author)
- University of Arkansas
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- Goldschmidt, Hartmut (author)
- University Hospital Heidelberg,National Centre of Tumor Diseases
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- Houlston, Richard (author)
- Institute of Cancer Research London
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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(creator_code:org_t)
- 2019-03-04
- 2019
- English.
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In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 2:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Inherited genetic susceptibility to multiple myeloma has been investigated in a number of studies. Although 23 individual risk loci have been identified, much of the genetic heritability remains unknown. Here we carried out genome-wide interaction analyses on two European cohorts accounting for 3,999 cases and 7,266 controls and characterized genetic susceptibility to multiple myeloma with subsequent meta-analysis that discovered 16 unique interacting loci. These risk loci along with previously known variants explain 17% of the heritability in liability scale. The genes associated with the interacting loci were found to be enriched in transforming growth factor beta signaling and circadian rhythm regulation pathways suggesting immunoglobulin trait modulation, TH17 cell differentiation and bone morphogenesis as mechanistic links between the predisposition markers and intrinsic multiple myeloma biology. Further tissue/cell-type enrichment analysis associated the discovered genes with hemic-immune system tissue types and immune-related cell types indicating overall involvement in immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Chattopadhyay, S ...
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Thomsen, Hauke
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Yadav, Pankaj
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da Silva Filho, ...
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Weinhold, Niels
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Nöthen, Markus M
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show more...
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Hoffman, Per
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Bertsch, Uta
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Huhn, Stefanie
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Morgan, Gareth J
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Goldschmidt, Har ...
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Houlston, Richar ...
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Hemminki, Kari
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Försti, Asta
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Communications B ...
- By the university
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Lund University