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GDNF and Parkinson'...
GDNF and Parkinson's Disease : Where Next? A Summary from a Recent Workshop
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- Barker, Roger A. (author)
- University of Cambridge
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- Björklund, Anders (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Gash, Don M. (author)
- University of Kentucky
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- Whone, Alan (author)
- North Bristol NHS Trust,University of Bristol
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- Van Laar, Amber (author)
- Brain Neurotherapy Bio Inc.
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- Kordower, Jeffrey H. (author)
- Rush University Medical Center Chicago
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- Bankiewicz, Krystof (author)
- Ohio State University
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- Kieburtz, Karl (author)
- University of Rochester Medical Center
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- Saarma, Mart (author)
- University of Helsinki
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- Booms, Sigrid (author)
- Herantis Pharma
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- Huttunen, Henri J. (author)
- Herantis Pharma,University of Helsinki
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- Kells, Adrian P. (author)
- Brain Neurotherapy Bio Inc.
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- Fiandaca, Massimo S. (author)
- Brain Neurotherapy Bio Inc.
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- Stoessl, A. Jon (author)
- University of British Columbia
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- Eidelberg, David (author)
- Feinstein Institute for Medical Research
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- Federoff, Howard (author)
- University of California, Irvine,Aspen Neuroscience, San Diego
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- Voutilainen, Merja H. (author)
- University of Helsinki
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- Dexter, David T. (author)
- Parkinson's UK
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- Eberling, Jamie (author)
- The Michael J. Fox Foundation for Parkinson’s Research
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- Brundin, Patrik (author)
- Van Andel Research Institute
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- Isaacs, Lyndsey (author)
- Cure Parkinson's Trust
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- Mursaleen, Leah (author)
- University of Westminster,Cure Parkinson's Trust
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- Bresolin, Eros (author)
- Cure Parkinson's Trust
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- Carroll, Camille (author)
- Plymouth University
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- Coles, Alasdair (author)
- University of Cambridge
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- Fiske, Brian (author)
- The Michael J. Fox Foundation for Parkinson’s Research
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- Matthews, Helen (author)
- Cure Parkinson's Trust
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- Lungu, Codrin (author)
- National Institute of Neurological Disorders and Stroke (NINDS)
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- Wyse, Richard K. (author)
- Cure Parkinson's Trust
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- Stott, Simon (author)
- Cure Parkinson's Trust
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- Lang, Anthony E. (author)
- Toronto Western Hospital,University of Toronto
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(creator_code:org_t)
- 2020
- 2020
- English 17 s.
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In: Journal of Parkinson's Disease. - 1877-7171. ; 10:3, s. 875-891
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Subject headings
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- The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This neurotrophic factor was discovered in 1993 and shown to have selective effects on promoting survival and regeneration of certain populations of neurons including the dopaminergic nigrostriatal pathway. These observations led to a series of clinical trials in PD patients including using infusions or gene delivery of GDNF or the related growth factor, neurturin (NRTN). Initial studies, some of which were open label, suggested that this approach could be of value in PD when the agent was injected into the putamen rather than the cerebral ventricles. In subsequent double-blind, placebo-controlled trials, the most recent reporting in 2019, treatment with GDNF did not achieve its primary end point. As a result, there has been uncertainty as to whether GDNF (and by extrapolation, related GDNF family neurotrophic factors) has merit in the future treatment of PD. To critically appraise the existing work and its future, a special workshop was held to discuss and debate this issue. This paper is a summary of that meeting with recommendations on whether there is a future for this therapeutic approach and also what any future PD trial involving GDNF and other GDNF family neurotrophic factors should consider in its design.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- clinical trials
- dopaminergic neurons
- GDNF
- NRTN
- Parkinson's disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Barker, Roger A.
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Björklund, Ander ...
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Gash, Don M.
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Whone, Alan
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Van Laar, Amber
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Kordower, Jeffre ...
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show more...
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Bankiewicz, Krys ...
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Kieburtz, Karl
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Saarma, Mart
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Booms, Sigrid
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Huttunen, Henri ...
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Kells, Adrian P.
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Fiandaca, Massim ...
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Stoessl, A. Jon
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Eidelberg, David
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Federoff, Howard
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Voutilainen, Mer ...
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Dexter, David T.
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Eberling, Jamie
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Brundin, Patrik
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Isaacs, Lyndsey
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Mursaleen, Leah
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Bresolin, Eros
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Carroll, Camille
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Coles, Alasdair
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Fiske, Brian
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Matthews, Helen
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Lungu, Codrin
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Wyse, Richard K.
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Stott, Simon
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Lang, Anthony E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Parki ...
- By the university
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Lund University