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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Estrada, Karol (author)
Styrkarsdottir, Unnur (author)
Evangelou, Evangelos (author)
show more...
Hsu, Yi-Hsiang (author)
Duncan, Emma L (author)
Ntzani, Evangelia E (author)
Oei, Ling (author)
Albagha, Omar M E (author)
Amin, Najaf (author)
Kemp, John P (author)
Koller, Daniel L (author)
Li, Guo (author)
Liu, Ching-Ti (author)
Minster, Ryan L (author)
Moayyeri, Alireza (author)
Vandenput, Liesbeth, 1974 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Willner, Dana (author)
Xiao, Su-Mei (author)
Yerges-Armstrong, Laura M (author)
Zheng, Hou-Feng (author)
Alonso, Nerea (author)
Eriksson, Joel (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Kammerer, Candace M (author)
Kaptoge, Stephen K (author)
Leo, Paul J (author)
Thorleifsson, Gudmar (author)
Wilson, Scott G (author)
Wilson, James F (author)
Aalto, Ville (author)
Alen, Markku (author)
Aragaki, Aaron K (author)
Aspelund, Thor (author)
Center, Jacqueline R (author)
Dailiana, Zoe (author)
Duggan, David J (author)
Garcia, Melissa (author)
Garcia-Giralt, Natalia (author)
Giroux, Sylvie (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hocking, Lynne J (author)
Husted, Lise Bjerre (author)
Jameson, Karen A (author)
Khusainova, Rita (author)
Kim, Ghi Su (author)
Kooperberg, Charles (author)
Koromila, Theodora (author)
Kruk, Marcin (author)
Laaksonen, Marika (author)
Lacroix, Andrea Z (author)
Lee, Seung Hun (author)
Leung, Ping C (author)
Lewis, Joshua R (author)
Masi, Laura (author)
Mencej-Bedrac, Simona (author)
Nguyen, Tuan V (author)
Nogues, Xavier (author)
Patel, Millan S (author)
Prezelj, Janez (author)
Rose, Lynda M (author)
Scollen, Serena (author)
Siggeirsdottir, Kristin (author)
Smith, Albert V (author)
Svensson, Olle (author)
Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
Trompet, Stella (author)
Trummer, Olivia (author)
Mellström, Dan, 1945 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Woo, Jean (author)
Zhu, Kun (author)
Balcells, Susana (author)
Brandi, Maria Luisa (author)
Buckley, Brendan M (author)
Cheng, Sulin (author)
Christiansen, Claus (author)
Cooper, Cyrus (author)
Dedoussis, George (author)
Ford, Ian (author)
Frost, Morten (author)
Goltzman, David (author)
Gonzalez-Macias, Jesus (author)
Kähönen, Mika (author)
Karlsson, Magnus (author)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
Khusnutdinova, Elza (author)
Koh, Jung-Min (author)
Kollia, Panagoula (author)
Langdahl, Bente Lomholt (author)
Leslie, William D (author)
Lips, Paul (author)
Ljunggren, Östen (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Metabola bensjukdomar
Lorenc, Roman S (author)
Marc, Janja (author)
Mellström, Dan, 1945 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Obermayer-Pietsch, Barbara (author)
Olmos, José M (author)
Pettersson-Kymmer, Ulrika (author)
Umeå universitet,Klinisk farmakologi
Reid, David M (author)
Riancho, José A (author)
Ridker, Paul M (author)
Rousseau, François (author)
Slagboom, P Eline (author)
Tang, Nelson L S (author)
Urreizti, Roser (author)
Van Hul, Wim (author)
Viikari, Jorma (author)
Zarrabeitia, María T (author)
Aulchenko, Yurii S (author)
Castano-Betancourt, Martha (author)
Grundberg, Elin (author)
Herrera, Lizbeth (author)
Ingvarsson, Thorvaldur (author)
Johannsdottir, Hrefna (author)
Kwan, Tony (author)
Li, Rui (author)
Luben, Robert (author)
Medina-Gomez, Carolina (author)
Palsson, Stefan Th (author)
Reppe, Sjur (author)
Rotter, Jerome I (author)
Sigurdsson, Gunnar (author)
van Meurs, Joyce B J (author)
Verlaan, Dominique (author)
Williams, Frances M K (author)
Wood, Andrew R (author)
Zhou, Yanhua (author)
Gautvik, Kaare M (author)
Pastinen, Tomi (author)
Raychaudhuri, Soumya (author)
Cauley, Jane A (author)
Chasman, Daniel I (author)
Clark, Graeme R (author)
Cummings, Steven R (author)
Danoy, Patrick (author)
Dennison, Elaine M (author)
Eastell, Richard (author)
Eisman, John A (author)
Gudnason, Vilmundur (author)
Hofman, Albert (author)
Jackson, Rebecca D (author)
Jones, Graeme (author)
Jukema, J Wouter (author)
Khaw, Kay-Tee (author)
Lehtimäki, Terho (author)
Liu, Yongmei (author)
Lorentzon, Mattias, 1970 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
McCloskey, Eugene (author)
Mitchell, Braxton D (author)
Nandakumar, Kannabiran (author)
Nicholson, Geoffrey C (author)
Oostra, Ben A (author)
Peacock, Munro (author)
Pols, Huibert A P (author)
Prince, Richard L (author)
Raitakari, Olli (author)
Reid, Ian R (author)
Robbins, John (author)
Sambrook, Philip N (author)
Sham, Pak Chung (author)
Shuldiner, Alan R (author)
Tylavsky, Frances A (author)
van Duijn, Cornelia M (author)
Wareham, Nick J (author)
Cupples, L Adrienne (author)
Econs, Michael J (author)
Evans, David M (author)
Harris, Tamara B (author)
Kung, Annie Wai Chee (author)
Psaty, Bruce M (author)
Reeve, Jonathan (author)
Spector, Timothy D (author)
Streeten, Elizabeth A (author)
Zillikens, M Carola (author)
Thorsteinsdottir, Unnur (author)
Ohlsson, Claes, 1965 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
Karasik, David (author)
Richards, J Brent (author)
Brown, Matthew A (author)
Stefansson, Kari (author)
Uitterlinden, Andre G (author)
Ralston, Stuart H (author)
Ioannidis, John P A (author)
Kiel, Douglas P (author)
Rivadeneira, Fernando (author)
show less...
 (creator_code:org_t)
2012-04-15
2012
English.
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

Keyword

Bone Density
genetics
Computational Biology
European Continental Ancestry Group
Extracellular Matrix Proteins
genetics
Female
Femur Neck
physiopathology
Fractures
Bone
genetics
Gene Expression Profiling
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Glycoproteins
genetics
Humans
Intercellular Signaling Peptides and Proteins
genetics
Low Density Lipoprotein Receptor-Related Protein-5
genetics
Lumbar Vertebrae
physiopathology
Male
Mitochondrial Membrane Transport Proteins
genetics
Osteoporosis
genetics
Phosphoproteins
genetics
Polymorphism
Single Nucleotide
genetics
Quantitative Trait Loci
Risk Factors
Spectrin
genetics
genetik
Orthopaedics

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Estrada, Karol
Styrkarsdottir, ...
Evangelou, Evang ...
Hsu, Yi-Hsiang
Duncan, Emma L
Ntzani, Evangeli ...
show more...
Oei, Ling
Albagha, Omar M ...
Amin, Najaf
Kemp, John P
Koller, Daniel L
Li, Guo
Liu, Ching-Ti
Minster, Ryan L
Moayyeri, Alirez ...
Vandenput, Liesb ...
Willner, Dana
Xiao, Su-Mei
Yerges-Armstrong ...
Zheng, Hou-Feng
Alonso, Nerea
Eriksson, Joel
Kammerer, Candac ...
Kaptoge, Stephen ...
Leo, Paul J
Thorleifsson, Gu ...
Wilson, Scott G
Wilson, James F
Aalto, Ville
Alen, Markku
Aragaki, Aaron K
Aspelund, Thor
Center, Jacqueli ...
Dailiana, Zoe
Duggan, David J
Garcia, Melissa
Garcia-Giralt, N ...
Giroux, Sylvie
Hallmans, Göran
Hocking, Lynne J
Husted, Lise Bje ...
Jameson, Karen A
Khusainova, Rita
Kim, Ghi Su
Kooperberg, Char ...
Koromila, Theodo ...
Kruk, Marcin
Laaksonen, Marik ...
Lacroix, Andrea ...
Lee, Seung Hun
Leung, Ping C
Lewis, Joshua R
Masi, Laura
Mencej-Bedrac, S ...
Nguyen, Tuan V
Nogues, Xavier
Patel, Millan S
Prezelj, Janez
Rose, Lynda M
Scollen, Serena
Siggeirsdottir, ...
Smith, Albert V
Svensson, Olle
Trompet, Stella
Trummer, Olivia
Mellström, Dan, ...
Woo, Jean
Zhu, Kun
Balcells, Susana
Brandi, Maria Lu ...
Buckley, Brendan ...
Cheng, Sulin
Christiansen, Cl ...
Cooper, Cyrus
Dedoussis, Georg ...
Ford, Ian
Frost, Morten
Goltzman, David
Gonzalez-Macias, ...
Kähönen, Mika
Karlsson, Magnus
Khusnutdinova, E ...
Koh, Jung-Min
Kollia, Panagoul ...
Langdahl, Bente ...
Leslie, William ...
Lips, Paul
Ljunggren, Östen
Lorenc, Roman S
Marc, Janja
Obermayer-Pietsc ...
Olmos, José M
Pettersson-Kymme ...
Reid, David M
Riancho, José A
Ridker, Paul M
Rousseau, Franço ...
Slagboom, P Elin ...
Tang, Nelson L S
Urreizti, Roser
Van Hul, Wim
Viikari, Jorma
Zarrabeitia, Mar ...
Aulchenko, Yurii ...
Castano-Betancou ...
Grundberg, Elin
Herrera, Lizbeth
Ingvarsson, Thor ...
Johannsdottir, H ...
Kwan, Tony
Li, Rui
Luben, Robert
Medina-Gomez, Ca ...
Palsson, Stefan ...
Reppe, Sjur
Rotter, Jerome I
Sigurdsson, Gunn ...
van Meurs, Joyce ...
Verlaan, Dominiq ...
Williams, France ...
Wood, Andrew R
Zhou, Yanhua
Gautvik, Kaare M
Pastinen, Tomi
Raychaudhuri, So ...
Cauley, Jane A
Chasman, Daniel ...
Clark, Graeme R
Cummings, Steven ...
Danoy, Patrick
Dennison, Elaine ...
Eastell, Richard
Eisman, John A
Gudnason, Vilmun ...
Hofman, Albert
Jackson, Rebecca ...
Jones, Graeme
Jukema, J Wouter
Khaw, Kay-Tee
Lehtimäki, Terho
Liu, Yongmei
Lorentzon, Matti ...
McCloskey, Eugen ...
Mitchell, Braxto ...
Nandakumar, Kann ...
Nicholson, Geoff ...
Oostra, Ben A
Peacock, Munro
Pols, Huibert A ...
Prince, Richard ...
Raitakari, Olli
Reid, Ian R
Robbins, John
Sambrook, Philip ...
Sham, Pak Chung
Shuldiner, Alan ...
Tylavsky, France ...
van Duijn, Corne ...
Wareham, Nick J
Cupples, L Adrie ...
Econs, Michael J
Evans, David M
Harris, Tamara B
Kung, Annie Wai ...
Psaty, Bruce M
Reeve, Jonathan
Spector, Timothy ...
Streeten, Elizab ...
Zillikens, M Car ...
Thorsteinsdottir ...
Ohlsson, Claes, ...
Karasik, David
Richards, J Bren ...
Brown, Matthew A
Stefansson, Kari
Uitterlinden, An ...
Ralston, Stuart ...
Ioannidis, John ...
Kiel, Douglas P
Rivadeneira, Fer ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Orthopaedics
Articles in the publication
Nature genetics
By the university
University of Gothenburg
Umeå University
Lund University
Uppsala University

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