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An Invasive or Cons...
An Invasive or Conservative Strategy in Patients With Diabetes Mellitus and Non-ST-Segment Elevation Acute Coronary Syndromes A Collaborative Meta-Analysis of Randomized Trials
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- O'Donoghue, Michelle L. (författare)
- Brigham and Womens Hospital, USA
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- Vaidya, Ajay (författare)
- University of Calif San Francisco, USA
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- Afsal, Rizwan (författare)
- McMaster University, Canada
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- Alfredsson, Joakim (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US
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- Boden, William E. (författare)
- Albany Stratton VA Medical Centre, USA
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- Braunwald, Eugene (författare)
- Brigham and Womens Hospital, USA
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- Cannon, Christopher P. (författare)
- Brigham and Womens Hospital, USA
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- Clayton, Tim C. (författare)
- London School Hyg and Trop Med, England
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- de Winter, Robbert J. (författare)
- University of Amsterdam, Netherlands
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- Fox, Keith A. A. (författare)
- University of Edinburgh, Scotland Royal Infirm Edinburgh NHS Trust, Scotland
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- Lagerqvist, Bo (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi,University of Uppsala Hospital, Sweden
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- McCullough, Peter A. (författare)
- St John Providence Health Syst Providence Pk Heart, MI USA
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- Murphy, Sabina A. (författare)
- Brigham and Womens Hospital, USA
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- Spacek, Rudolf (författare)
- 3rd Medical Fac Prague, Czech Republic
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- Swahn, Eva (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US
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- Windhausen, Fons (författare)
- University of Amsterdam, Netherlands
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- Sabatine, Marc S. (författare)
- Brigham and Womens Hospital, USA
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 60:2, s. 106-111
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Objectives The purpose of this study was to conduct a meta-analysis to examine an invasive or conservative strategy in diabetic versus nondiabetic patients. Background Diabetic patients are at increased risk of cardiovascular events after an acute coronary syndrome, yet it remains unknown whether they derive enhanced benefit from an invasive strategy.Methods Randomized trials comparing an invasive versus conservative treatment strategy were identified. The prevalence of cardiovascular events through 12 months was reported for each trial, stratified by diabetes mellitus status and randomized treatment strategy. Relative risk (RR) ratios and absolute risk reductions were combined using random-effects models.Results Data were combined across 9 trials comprising 9,904 subjects of whom 1,789 (18.1%) had diabetes mellitus. The RRs for death, nonfatal myocardial infarction (MI), or rehospitalization with an acute coronary syndrome for an invasive versus conservative strategy were similar between diabetic patients (RR: 0.87; 95% confidence interval [CI]: 0.73 to 1.03) and nondiabetic patients (RR: 0.86; 95% CI: 0.70 to 1.06; p interaction = 0.83). An invasive strategy reduced nonfatal MI in diabetic patients (RR: 0.71; 95% CI: 0.55 to 0.92), but not in nondiabetic patients (RR: 0.98; 95% CI: 0.74 to 1.29; p interaction = 0.09). The absolute risk reduction in MI with an invasive strategy was greater in diabetic than nondiabetic patients (absolute risk reduction: 3.7% vs. 0.1%; p interaction = 0.02). There were no differences in death or stroke between groups (p interactions 0.68 and 0.20, respectively).Conclusions An early invasive strategy yielded similar RR reductions in overall cardiovascular events in diabetic and nondiabetic patients. However, an invasive strategy appeared to reduce recurrent nonfatal MI to a greater extent in diabetic patients. These data support the updated guidelines that recommend an invasive strategy for patients with diabetes mellitus and non-ST-segment elevation acute coronary syndromes.
Nyckelord
- conservative strategy
- diabetes mellitus
- invasive strategy
- meta-analysis
- MEDICINE
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- art (ämneskategori)
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O'Donoghue, Mich ...
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Vaidya, Ajay
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Afsal, Rizwan
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Alfredsson, Joak ...
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Boden, William E ...
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Braunwald, Eugen ...
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Cannon, Christop ...
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Clayton, Tim C.
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de Winter, Robbe ...
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Fox, Keith A. A.
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Lagerqvist, Bo
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McCullough, Pete ...
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Murphy, Sabina A ...
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Spacek, Rudolf
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Swahn, Eva
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Windhausen, Fons
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Sabatine, Marc S ...
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Uppsala universitet
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