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Amyloid-beta, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data

Bos, I. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
Vos, S. J. B. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
Jansen, W. J. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
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Vandenberghe, R. (författare)
University Hospital Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences KU Leuven, Leuven, Belgium
Gabel, S. (författare)
Laboratory for Cognitive Neurology, Department of Neurosciences KU Leuven, Leuven, Belgium; Alzheimer Research Centre KU Leuven, Leuven, Belgium,Department of Neurology Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Estanga, A. (författare)
Center for Research and Advanced Therapies CITA-Alzheimer Foundation, San Sebastián, Spain
Ecay-Torres, M. (författare)
Center for Research and Advanced Therapies CITA-Alzheimer Foundation, San Sebastián, Spain
Tomassen, J. (författare)
Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center VU University Amsterdam, Amsterdam, Netherlands
den Braber, A. (författare)
Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center VU University Amsterdam, Amsterdam, Netherlands; Department of Biological Psychology VU University Amsterdam, Amsterdam, Netherlands
Lleo, A. (författare)
Department of Neurology Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Sala, I. (författare)
Wallin, Anders, 1950 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden
Kettunen, Petronella (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
Molinuevo, J. L. (författare)
Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
Rami, L. (författare)
Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
Chetelat, G. (författare)
Institut National de la Santé et de la Recherche Médicale UMR-S U1237, Université de Caen-Normandie GIP Cyceron, Caen, France
de la Sayette, V. (författare)
Institut National de la Santé et de la Recherche Médicale U1077, Université de Caen Normandie Ecole Pratique des Hautes Etudes, Caen, France; CHU de Caen Service de Neurologie, Caen, France
Tsolaki, M. (författare)
1st Department of Neurology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece
Freund-Levi, Yvonne, 1956- (författare)
Division of Clinical Geriatrics, Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Norrtälje Hospital Tiohundra, Norrtälje, Sweden
Johannsen, P. (författare)
Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
Novak, G. P. (författare)
Janssen Pharmaceutical Research and Development, Titusville, NJ, United States
Ramakers, I. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
Verhey, F. R. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
Visser, P. J. (författare)
Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, Netherlands
Alzheimers Dis Neuroimaging, Initia (författare)
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 (creator_code:org_t)
2018-06-25
2018
Engelska.
Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media SA. - 1663-4365. ; 10
Relaterad länk:
https://www.frontier...
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https://doi.org/10.3...
https://gup.ub.gu.se...
https://doi.org/10.3...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • We investigated whether amyloid-beta (A beta) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had A beta status and neuropsychological data available. Linear mixed models were used to assess the associations of Ali and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B). All test except the VFT were associated with status and this influence was augmented by age. We found no influence of tau on any of the cognitive tests. For the AVLT Immediate and Delayed recall and the TMT part A and B, we calculated norms in individuals without A beta pathology (A beta- norms), which we validated in an independent memory-clinic cohort by comparing their predictive accuracy to published norms. For memory tests, the A beta- norms rightfully identified an additional group of individuals at risk of dementia. For non-memory test we found no difference. We confirmed the relationship between Ao and cognition in cognitively normal individuals. The Af3- norms for memory tests in combination with published norms improve prognostic accuracy of dementia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Alzheimer's disease
amyloid-beta
tau
cognition
neuropsychological examination
normative data
preclinical alzheimers-disease
cerebrospinal-fluid biomarkers
diagnostic-criteria
international workshop
dementia
impairment
adults
age
decline
participants
Geriatrics & Gerontology
Neurosciences & Neurology
lstein mf
1975
journal of psychiatric research
v12
p189
khann g
1984
neurology
v34
p939
Alzheimer's disease

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