In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

• A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Elektroteknik och elektronik -- Signalbehandling (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Electrical Engineering, Electronic Engineering, Information Engineering -- Signal Processing (hsv//eng)

Nyckelord

computers in chemistry

computer program

MEDICINE

MEDICIN

Signal processing

Signalbehandling

Electrical Engineering with specialization in Signal Processing

Elektroteknik med inriktning mot signalbehandling

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)