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Preoperative neutro...
Preoperative neutrophil-to-lymphocyte ratio is prognostic for early recurrence after curative intrahepatic cholangiocarcinoma resection
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- Choi, Woo Jin (författare)
- Univ Toronto, Dept Surg, 585 Univ Ave, Toronto, ON M5G 2N2, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Univ Toronto, Inst Hlth Policy Management & Evaluat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
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- Murillo Perez, Fiorella (författare)
- Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada.
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- Gravely, Annabel (författare)
- Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada.
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visa fler...
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- Ivanics, Tommy (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada; Henry Ford Hosp, Dept Surg, Detroit, MI USA
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- Claasen, Marco P. A. W. (författare)
- Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.
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- Abraham, Liza (författare)
- Univ Toronto, Dept Surg, 585 Univ Ave, Toronto, ON M5G 2N2, Canada.
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- Abreu, Phillipe (författare)
- Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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- Visser, Robin (författare)
- Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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- Gallinger, Steven (författare)
- Univ Toronto, Dept Surg, 585 Univ Ave, Toronto, ON M5G 2N2, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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- Hansen, Bettina E. (författare)
- Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada.;Univ Toronto, Inst Hlth Policy Management & Evaluat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
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- Sapisochin, Gonzalo (författare)
- Univ Toronto, Dept Surg, 585 Univ Ave, Toronto, ON M5G 2N2, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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Univ Toronto, Dept Surg, 585 Univ Ave, Toronto, ON M5G 2N2, Canada;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Univ Toronto, Inst Hlth Policy Management & Evaluat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada. (creator_code:org_t)
- 2023-02-20
- 2023
- Engelska.
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Ingår i: Annals of Hepato-Biliary-Pancreatic Surgery. - : The Korean Association of Hepato-Biliary-Pancreatic Surgery. - 2508-5778 .- 2508-5859. ; 27:2, s. 158-165
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Backgrounds/Aims: Within two years of surgery, 70% of resected intrahepatic cholangiocarcinoma (iCCA) recur. Better biomarkers are needed to identify those at risk of “early recurrence” (ER). In this study, we defined ER and investigated whether preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-inflammatory index were prognostic of both overall relapse and ER after curative hepatectomy for iCCA.Methods: A retrospective cohort of patients who underwent curative-intent hepatectomy for iCCA between 2005 and 2017 were created. The cut-off timepoint for the ER of iCCA was estimated using a piecewise linear regression model. Univariable analyses of recurrence were conducted for the overall, early, and late recurrence periods. For the early and late recurrence periods, multivariable Cox regression with time-varying regression coefficient analysis was used.Results: A total of 113 patients were included in this study. ER was defined as recurrence within 12 months of a curative resection. Among the included patients, 38.1% experienced ER. In the univariable model, a higher preoperative NLR (> 4.3) was significantly associated with an increased risk of recurrence overall and in the first 12 months after curative surgery. In the multivariable model, a higher NLR was associated with a higher recurrence rate overall and in the ER period (≤ 12 months), but not in the late recurrence period.Conclusions: Preoperative NLR was prognostic of both overall recurrence and ER after curative iCCA resection. NLR is easily obtained before and after surgery and should be integrated into ER prediction tools to guide preoperative treatments and intensify postoperative follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cholangiocarcinoma
- Hepatectomy
- Recurrence
- Liver
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Choi, Woo Jin
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Murillo Perez, F ...
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Gravely, Annabel
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Ivanics, Tommy
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Claasen, Marco P ...
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Abraham, Liza
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visa fler...
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Abreu, Phillipe
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Visser, Robin
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Gallinger, Steve ...
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Hansen, Bettina ...
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Sapisochin, Gonz ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Annals of Hepato ...
- Av lärosätet
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Uppsala universitet