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Sökning: onr:"swepub:oai:DiVA.org:umu-202958" > Association between...

Association between Smoking and Molecular Subtypes of Colorectal Cancer

Wang, Xiaoliang (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Amitay, Efrat (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ, Heidelberg, Germany
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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Banbury, Barbara L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Berndt, Sonja I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Brenner, Hermann (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Buchanan, Daniel D. (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ, Heidelberg, Germany; Department of Preventive Oncology, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Campbell, Peter T. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Parkville, Australia; Department of Clinical Pathology, Colorectal Oncogenomics Group, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Melbourne, Australia
Cao, Yin (författare)
Epidemiology Research Program, American Cancer Society, GA, Atlanta, United States
Chan, Andrew T. (författare)
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, MO, St Louis, United States; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
Chang-Claude, Jenny (författare)
Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States
Gallinger, Steven J. (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Genetic Tumour Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Giannakis, Marios (författare)
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
Giles, Graham G. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Gunter, Marc J. (författare)
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
Hopper, John L. (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Parkville, Australia
Lin, Yi (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Parkville, Australia
Moreno, Victor (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Nishihara, Reiko (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Parkville, Australia
Newcomb, Polly A. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Ogino, Shuji (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Phipps, Amanda I. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Parkville, Australia; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Schoen, Robert E. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Slattery, Martha L. (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States
Song, Mingyang (författare)
Department of Internal Medicine, University of Utah Health Sciences Center, UT, Salt Lake City, United States
Sun, Wei (författare)
Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Thibodeau, Steven N. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Toland, Amanda E. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
van Guelpen, Bethany (författare)
Umeå universitet,Onkologi
Woods, Michael O. (författare)
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland & Labrador, Canada
Hsu, Li (författare)
Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland and Labrador, Canada
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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 (creator_code:org_t)
2021-06-14
2021
Engelska.
Ingår i: JNCI Cancer Spectrum. - : Oxford University Press. - 2515-5091. ; 5:4
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC, but large-scale comprehensive analysis is lacking.Methods: A total of 9789 CRC cases and 11 231 controls of European ancestry from 11 observational studies were included. We harmonized smoking variables across studies and derived sex study specific quartiles of pack-years of smoking for analysis. Four somatic colorectal tumor markers were assessed individually and in combination, including BRAF mutation, KRAS mutation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) status. A multinomial logistic regression analysis was used to assess the association between smoking and risk of CRC subtypes by molecular characteristics, adjusting for age, sex, and study. All statistical tests were 2-sided and adjusted for Bonferroni correction.Results: Heavier smoking was associated with higher risk of CRC overall and stratified by individual markers (P < .trend <01). The associations differed statistically significantly between all molecular subtypes, which was the most statistically significant for CIMP and BRAF. Compared with never-smokers, smokers in the fourth quartile of pack-years had a 90% higher risk of CIMP-positive CRC (odds ratio 1.90, 95% confidence interval 1.60 to 2.26) but only 35% higher risk for CIMP-negative CRC (odds ratio=1.35, 95% confidence interval 1.22 to 1.49; Pdifference 2.1 × 10-6). The association was also stronger in tumors that were CIMP positive, MSI high, or KRAS wild type when combined (Pdifference < .001).Conclusion: Smoking was associated with differential risk of CRC subtypes defined by molecular characteristics. Heavier smokers had particularly higher risk of CRC subtypes that were CIMP positive and MSI high in combination, suggesting that smoking may be involved in the development of colorectal tumors via the serrated pathway.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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