Sökning: WFRF:(Gao Xiaoyi)
> (2012) >
Understanding the i...
Understanding the influence of alendronate on the morphology and phase transformation of apatitic precursor nanocrystals
-
- Zhang, Guiling (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
- Huang, Rong (författare)
- Key Laboratory of Polar Materials and Devices, Ministry of Education, East China Normal University, Shanghai, Kina
-
- Li, Zhicheng (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
visa fler...
-
- Yang, Xianyan (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
- Chen, Xiaoyi (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
- Xia, Wei (författare)
- Uppsala universitet,Tillämpad materialvetenskap
-
- Sun, Xiaoliang (författare)
- Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, Ruian, Kina
-
- Yang, Guojing (författare)
- Rui'an People's Hospital & the 3rd Hospital Affiliated to Wenzhou Medical College, Ruian, Kina
-
- Gao, Changyou (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
- Gou, Zhongru (författare)
- Bio-Nanomaterials and Regeneration Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Kina
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
-
Ingår i: Journal of Inorganic Biochemistry. - : Elsevier BV. - 0162-0134 .- 1873-3344. ; 113, s. 1-8
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Bisphosphonates (BPs) are a class of synthetic pyrophosphate analogs that can prevent the loss of bone mass, given orally to treat postmenopuasal osteoporosis. It is not clear yet if the benefits of BPs include the possibility of affecting bone apatitic precursors transition for bone consolidation except for encouraging osteoclasts to undergo apoptosis. Furthermore, the complexity of the in vivo system makes it difficult to isolate and study such extracellular topographical cues that trigger bone turnover response. Herein, we proposed a wet-chemical approach employing alendronate sodium (AS) as a guide of hydroxyapatite (HA) precursor growth and conversion which was initiated from the nucleantion of octacalcium phosphate (OCP) in a cell membrane-mimicking surfactant micelle aqueous system. The nanocrystal clusters of dicalcium phosphate dihydrate (DCPD) and OCP nanocryatals were readily precipitated within a relatively narrow AS concentration range (2-8 mu M). However, such low concentrations of AS seemed to stabilize the more acidic phases, and to delay the transformation into HA, to an extent which increased on increasing AS concentration. In contrast, at a slight higher concentrations (16-32 mu M), AS promoted HA precipitation after ageing for 1 h. It was found that the effect of AS on the phase selectivity of apatitic precursors was concentration-dependent within a prolonged ageing time stage (0.5-168 h). The AS-assisted reactions in vitro offer an expedient way to understand the underlying implementarity between bone and BPs for bone consolidation, and to improve our understanding of benefit of BP dosages on bone turnover and trauma healing.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- Apatitic precursor
- Bisphosphonates
- Phase transformation
- In vitro
- Bone consolidation
- Osteoporosis
- TECHNOLOGY
- TEKNIKVETENSKAP
- Engineering Science with specialization in Materials Science
- Teknisk fysik med inriktning mot materialvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Zhang, Guiling
-
Huang, Rong
-
Li, Zhicheng
-
Yang, Xianyan
-
Chen, Xiaoyi
-
Xia, Wei
-
visa fler...
-
Sun, Xiaoliang
-
Yang, Guojing
-
Gao, Changyou
-
Gou, Zhongru
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
- Artiklar i publikationen
-
Journal of Inorg ...
- Av lärosätet
-
Uppsala universitet