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WFRF:(Giles Graham G.)
 

Search: WFRF:(Giles Graham G.) > (2015-2019) > (2019) > Novel Common Geneti...

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Schmit, Stephanie L (author)
Edlund, Christopher K (author)
Schumacher, Fredrick R (author)
show more...
Gong, Jian (author)
Harrison, Tabitha A (author)
Huyghe, Jeroen R (author)
Qu, Chenxu (author)
Melas, Marilena (author)
Van Den Berg, David J (author)
Wang, Hansong (author)
Tring, Stephanie (author)
Plummer, Sarah J (author)
Albanes, Demetrius (author)
Alonso, M Henar (author)
Amos, Christopher I (author)
Anton, Kristen (author)
Aragaki, Aaron K (author)
Arndt, Volker (author)
Barry, Elizabeth L (author)
Berndt, Sonja I (author)
Bezieau, Stéphane (author)
Bien, Stephanie (author)
Bloomer, Amanda (author)
Boehm, Juergen (author)
Boutron-Ruault, Marie-Christine (author)
Brenner, Hermann (author)
Brezina, Stefanie (author)
Buchanan, Daniel D (author)
Butterbach, Katja (author)
Caan, Bette J (author)
Campbell, Peter T (author)
Carlson, Christopher S (author)
Castelao, Jose E (author)
Chan, Andrew T (author)
Chang-Claude, Jenny (author)
Chanock, Stephen J (author)
Cheng, Iona (author)
Cheng, Ya-Wen (author)
Chin, Lee Soo (author)
Church, James M (author)
Church, Timothy (author)
Coetzee, Gerhard A (author)
Cotterchio, Michelle (author)
Cruz Correa, Marcia (author)
Curtis, Keith R (author)
Duggan, David (author)
Easton, Douglas F (author)
English, Dallas (author)
Feskens, Edith J M (author)
Fischer, Rocky (author)
FitzGerald, Liesel M (author)
Fortini, Barbara K (author)
Fritsche, Lars G (author)
Fuchs, Charles S (author)
Gago-Dominguez, Manuela (author)
Gala, Manish (author)
Gallinger, Steven J (author)
Gauderman, W James (author)
Giles, Graham G (author)
Giovannucci, Edward L (author)
Gogarten, Stephanie M (author)
Gonzalez-Villalpando, Clicerio (author)
Gonzalez-Villalpando, Elena M (author)
Grady, William M (author)
Greenson, Joel K (author)
Gsur, Andrea (author)
Gunter, Marc (author)
Haiman, Christopher A (author)
Hampe, Jochen (author)
Harlid, Sophia, 1978- (author)
Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Harju, John F (author)
Hayes, Richard B (author)
Hofer, Philipp (author)
Hoffmeister, Michael (author)
Hopper, John L (author)
Huang, Shu-Chen (author)
Huerta, Jose Maria (author)
Hudson, Thomas J (author)
Hunter, David J (author)
Idos, Gregory E (author)
Iwasaki, Motoki (author)
Jackson, Rebecca D (author)
Jacobs, Eric J (author)
Jee, Sun Ha (author)
Jenkins, Mark A (author)
Jia, Wei-Hua (author)
Jiao, Shuo (author)
Joshi, Amit D (author)
Kolonel, Laurence N (author)
Kono, Suminori (author)
Kooperberg, Charles (author)
Krogh, Vittorio (author)
Kuehn, Tilman (author)
Küry, Sébastien (author)
LaCroix, Andrea (author)
Laurie, Cecelia A (author)
Lejbkowicz, Flavio (author)
Lemire, Mathieu (author)
Lenz, Heinz-Josef (author)
Levine, David (author)
Li, Christopher I (author)
Li, Li (author)
Lieb, Wolfgang (author)
Lin, Yi (author)
Lindor, Noralane M (author)
Liu, Yun-Ru (author)
Loupakis, Fotios (author)
Lu, Yingchang (author)
Luh, Frank (author)
Ma, Jing (author)
Mancao, Christoph (author)
Manion, Frank J (author)
Markowitz, Sanford D (author)
Martin, Vicente (author)
Matsuda, Koichi (author)
Matsuo, Keitaro (author)
McDonnell, Kevin J (author)
McNeil, Caroline E (author)
Milne, Roger (author)
Molina, Antonio J (author)
Mukherjee, Bhramar (author)
Murphy, Neil (author)
Newcomb, Polly A (author)
Offit, Kenneth (author)
Omichessan, Hanane (author)
Palli, Domenico (author)
Cotoré, Jesus P Paredes (author)
Pérez-Mayoral, Julyann (author)
Pharoah, Paul D (author)
Potter, John D (author)
Qu, Conghui (author)
Raskin, Leon (author)
Rennert, Gad (author)
Rennert, Hedy S (author)
Riggs, Bridget M (author)
Schafmayer, Clemens (author)
Schoen, Robert E (author)
Sellers, Thomas A (author)
Seminara, Daniela (author)
Severi, Gianluca (author)
Shi, Wei (author)
Shibata, David (author)
Shu, Xiao-Ou (author)
Siegel, Erin M (author)
Slattery, Martha L (author)
Southey, Melissa (author)
Stadler, Zsofia K (author)
Stern, Mariana C (author)
Stintzing, Sebastian (author)
Taverna, Darin (author)
Thibodeau, Stephen N (author)
Thomas, Duncan C (author)
Trichopoulou, Antonia (author)
Tsugane, Shoichiro (author)
Ulrich, Cornelia M (author)
van Duijnhoven, Franzel J B (author)
van Guelpen, Bethany (author)
Umeå universitet,Onkologi
Vijai, Joseph (author)
Virtamo, Jarmo (author)
Weinstein, Stephanie J (author)
White, Emily (author)
Win, Aung Ko (author)
Wolk, Alicja (author)
Karolinska Institutet
Woods, Michael (author)
Wu, Anna H (author)
Wu, Kana (author)
Xiang, Yong-Bing (author)
Yen, Yun (author)
Zanke, Brent W (author)
Zeng, Yi-Xin (author)
Zhang, Ben (author)
Zubair, Niha (author)
Kweon, Sun-Seog (author)
Figueiredo, Jane C (author)
Zheng, Wei (author)
Marchand, Loic Le (author)
Lindblom, Annika (author)
Karolinska Institutet
Moreno, Victor (author)
Peters, Ulrike (author)
Casey, Graham (author)
Hsu, Li (author)
Conti, David V (author)
Gruber, Stephen B (author)
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 (creator_code:org_t)
2018-06-16
2019
English.
In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 111:2, s. 146-157
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.Results: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.Conclusions: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Schmit, Stephani ...
Edlund, Christop ...
Schumacher, Fred ...
Gong, Jian
Harrison, Tabith ...
Huyghe, Jeroen R
show more...
Qu, Chenxu
Melas, Marilena
Van Den Berg, Da ...
Wang, Hansong
Tring, Stephanie
Plummer, Sarah J
Albanes, Demetri ...
Alonso, M Henar
Amos, Christophe ...
Anton, Kristen
Aragaki, Aaron K
Arndt, Volker
Barry, Elizabeth ...
Berndt, Sonja I
Bezieau, Stéphan ...
Bien, Stephanie
Bloomer, Amanda
Boehm, Juergen
Boutron-Ruault, ...
Brenner, Hermann
Brezina, Stefani ...
Buchanan, Daniel ...
Butterbach, Katj ...
Caan, Bette J
Campbell, Peter ...
Carlson, Christo ...
Castelao, Jose E
Chan, Andrew T
Chang-Claude, Je ...
Chanock, Stephen ...
Cheng, Iona
Cheng, Ya-Wen
Chin, Lee Soo
Church, James M
Church, Timothy
Coetzee, Gerhard ...
Cotterchio, Mich ...
Cruz Correa, Mar ...
Curtis, Keith R
Duggan, David
Easton, Douglas ...
English, Dallas
Feskens, Edith J ...
Fischer, Rocky
FitzGerald, Lies ...
Fortini, Barbara ...
Fritsche, Lars G
Fuchs, Charles S
Gago-Dominguez, ...
Gala, Manish
Gallinger, Steve ...
Gauderman, W Jam ...
Giles, Graham G
Giovannucci, Edw ...
Gogarten, Stepha ...
Gonzalez-Villalp ...
Gonzalez-Villalp ...
Grady, William M
Greenson, Joel K
Gsur, Andrea
Gunter, Marc
Haiman, Christop ...
Hampe, Jochen
Harlid, Sophia, ...
Harju, John F
Hayes, Richard B
Hofer, Philipp
Hoffmeister, Mic ...
Hopper, John L
Huang, Shu-Chen
Huerta, Jose Mar ...
Hudson, Thomas J
Hunter, David J
Idos, Gregory E
Iwasaki, Motoki
Jackson, Rebecca ...
Jacobs, Eric J
Jee, Sun Ha
Jenkins, Mark A
Jia, Wei-Hua
Jiao, Shuo
Joshi, Amit D
Kolonel, Laurenc ...
Kono, Suminori
Kooperberg, Char ...
Krogh, Vittorio
Kuehn, Tilman
Küry, Sébastien
LaCroix, Andrea
Laurie, Cecelia ...
Lejbkowicz, Flav ...
Lemire, Mathieu
Lenz, Heinz-Jose ...
Levine, David
Li, Christopher ...
Li, Li
Lieb, Wolfgang
Lin, Yi
Lindor, Noralane ...
Liu, Yun-Ru
Loupakis, Fotios
Lu, Yingchang
Luh, Frank
Ma, Jing
Mancao, Christop ...
Manion, Frank J
Markowitz, Sanfo ...
Martin, Vicente
Matsuda, Koichi
Matsuo, Keitaro
McDonnell, Kevin ...
McNeil, Caroline ...
Milne, Roger
Molina, Antonio ...
Mukherjee, Bhram ...
Murphy, Neil
Newcomb, Polly A
Offit, Kenneth
Omichessan, Hana ...
Palli, Domenico
Cotoré, Jesus P ...
Pérez-Mayoral, J ...
Pharoah, Paul D
Potter, John D
Qu, Conghui
Raskin, Leon
Rennert, Gad
Rennert, Hedy S
Riggs, Bridget M
Schafmayer, Clem ...
Schoen, Robert E
Sellers, Thomas ...
Seminara, Daniel ...
Severi, Gianluca
Shi, Wei
Shibata, David
Shu, Xiao-Ou
Siegel, Erin M
Slattery, Martha ...
Southey, Melissa
Stadler, Zsofia ...
Stern, Mariana C
Stintzing, Sebas ...
Taverna, Darin
Thibodeau, Steph ...
Thomas, Duncan C
Trichopoulou, An ...
Tsugane, Shoichi ...
Ulrich, Cornelia ...
van Duijnhoven, ...
van Guelpen, Bet ...
Vijai, Joseph
Virtamo, Jarmo
Weinstein, Steph ...
White, Emily
Win, Aung Ko
Wolk, Alicja
Woods, Michael
Wu, Anna H
Wu, Kana
Xiang, Yong-Bing
Yen, Yun
Zanke, Brent W
Zeng, Yi-Xin
Zhang, Ben
Zubair, Niha
Kweon, Sun-Seog
Figueiredo, Jane ...
Zheng, Wei
Marchand, Loic L ...
Lindblom, Annika
Moreno, Victor
Peters, Ulrike
Casey, Graham
Hsu, Li
Conti, David V
Gruber, Stephen ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Journal of the N ...
By the university
Uppsala University
Umeå University
Karolinska Institutet

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