Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Giovannucci Edward L) > (2015-2019) > Agnostic Pathway/Ge...

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh, Naomi (author)

Zhang, Han (author)

Hyland, Paula L. (author)

Yang, Qi (author)

Mocci, Evelina (author)

Zhang, Mingfeng (author)

Childs, Erica J. (author)

Collins, Irene (author)

Wang, Zhaoming (author)

Arslan, Alan A. (author)

Beane-Freeman, Laura (author)

Bracci, Paige M. (author)

Brennan, Paul (author)

Canzian, Federico (author)

Duell, Eric J. (author)

Gallinger, Steven (author)

Giles, Graham G. (author)

Goggins, Michael (author)

Goodman, Gary E. (author)

Goodman, Phyllis J. (author)

Hung, Rayjean J. (author)

Kooperberg, Charles (author)

Kurtz, Robert C. (author)

Malats, Núria (author)

LeMarchand, Loic (author)

Neale, Rachel E. (author)

Olson, Sara H. (author)

Scelo, Ghislaine (author)

Shu, Xiao O. (author)

Van Den Eeden, Stephen K. (author)

Visvanathan, Kala (author)

White, Emily (author)

Zheng, Wei (author)

Albanes, Demetrius (author)

Andreotti, Gabriella (author)

Babic, Ana (author)

Bamlet, William R. (author)

Berndt, Sonja I. (author)

Borgida, Ayelet (author)

Boutron-Ruault, Marie-Christine (author)

Brais, Lauren (author)

Bueno-de-Mesquita, Bas (author)

Buring, Julie (author)

Chaffee, Kari G. (author)

Chanock, Stephen (author)

Cleary, Sean (author)

Cotterchio, Michelle (author)

Foretova, Lenka (author)

Fuchs, Charles (author)

M. Gaziano, J. Michael (author)

Giovannucci, Edward (author)

Goggins, Michael (author)

Hackert, Thilo (author)

Haiman, Christopher (author)

Hartge, Patricia (author)

Hasan, Manal (author)

Helzlsouer, Kathy J. (author)

Herman, Joseph (author)

Holcatova, Ivana (author)

Holly, Elizabeth A. (author)

Hoover, Robert (author)

Hung, Rayjean J. (author)

Janout, Vladimir (author)

Klein, Eric A. (author)

Kurtz, Robert C. (author)

Laheru, Daniel (author)

Lee, I-Min (author)

Lu, Lingeng (author)

Malats, Núria (author)

Mannisto, Satu (author)

Milne, Roger L. (author)

Oberg, Ann L. (author)

Orlow, Irene (author)

Patel, Alpa V. (author)

Peters, Ulrike (author)

Porta, Miquel (author)

Real, Francisco X. (author)

Rothman, Nathaniel (author)

Sesso, Howard D. (author)

Severi, Gianluca (author)

Silverman, Debra (author)

Strobel, Oliver (author)

Sund, Malin (author): Umeå universitet,Kirurgi,Sund

Thornquist, Mark D. (author)

Tobias, Geoffrey S. (author)

Wactawski-Wende, Jean (author)

Wareham, Nick (author)

Weiderpass, Elisabete (author): Karolinska Institutet

Wentzensen, Nicolas (author)

Wheeler, William (author)

Yu, Herbert (author)

Zeleniuch-Jacquotte, Anne (author)

Kraft, Peter (author)

Li, Donghui (author)

Jacobs, Eric J. (author)

Petersen, Gloria M. (author)

Wolpin, Brian M. (author)

Risch, Harvey A. (author)

Amundadottir, Laufey T. (author)

Yu, Kai (author)

Klein, Alison P. (author)

Stolzenberg-Solomon, Rachael Z. (author)

show less...

(creator_code:org_t)

2018-12-12
2019
English.
In: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 111:6

Related links:: https://europepmc.or...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. We performed expression quantitative trait loci (eQTL) analysis and functional annotation of the top SNPs in genes contributing to the top associated pathways and gene sets. All statistical tests were two-sided.Results: We identified 14 pathways and gene sets associated with PDAC at a false discovery rate of less than 0.05. After Bonferroni correction (P ≤ 1.3 × 10-5), the strongest associations were detected in five pathways and gene sets, including maturity-onset diabetes of the young, regulation of beta-cell development, role of epidermal growth factor (EGF) receptor transactivation by G protein-coupled receptors in cardiac hypertrophy pathways, and the Nikolsky breast cancer chr17q11-q21 amplicon and Pujana ATM Pearson correlation coefficient (PCC) network gene sets. We identified and validated rs876493 and three correlating SNPs (PGAP3) and rs3124737 (CASP7) from the Pujana ATM PCC gene set as eQTLs in two normal derived pancreas tissue datasets.Conclusion: Our agnostic pathway and gene set analysis integrated with functional annotation and eQTL analysis provides insight into genes and pathways that may be biologically relevant for risk of PDAC, including those not previously identified.

Find in a library

Journal of the National Cancer Institute (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Walsh, Naomi; Zhang, Han; Hyland, Paula L.; Yang, Qi; Mocci, Evelina; Zhang, Mingfeng; show more...; Childs, Erica J.; Collins, Irene; Wang, Zhaoming; Arslan, Alan A.; Beane-Freeman, L ...; Bracci, Paige M.; Brennan, Paul; Canzian, Federic ...; Duell, Eric J.; Gallinger, Steve ...; Giles, Graham G.; Goggins, Michael; Goodman, Gary E.; Goodman, Phyllis ...; Hung, Rayjean J.; Kooperberg, Char ...; Kurtz, Robert C.; Malats, Núria; LeMarchand, Loic; Neale, Rachel E.; Olson, Sara H.; Scelo, Ghislaine; Shu, Xiao O.; Van Den Eeden, S ...; Visvanathan, Kal ...; White, Emily; Zheng, Wei; Albanes, Demetri ...; Andreotti, Gabri ...; Babic, Ana; Bamlet, William ...; Berndt, Sonja I.; Borgida, Ayelet; Boutron-Ruault, ...; Brais, Lauren; Bueno-de-Mesquit ...; Buring, Julie; Chaffee, Kari G.; Chanock, Stephen; Cleary, Sean; Cotterchio, Mich ...; Foretova, Lenka; Fuchs, Charles; M. Gaziano, J. M ...; Giovannucci, Edw ...; Hackert, Thilo; Haiman, Christop ...; Hartge, Patricia; Hasan, Manal; Helzlsouer, Kath ...; Herman, Joseph; Holcatova, Ivana; Holly, Elizabeth ...; Hoover, Robert; Janout, Vladimir; Klein, Eric A.; Laheru, Daniel; Lee, I-Min; Lu, Lingeng; Mannisto, Satu; Milne, Roger L.; Oberg, Ann L.; Orlow, Irene; Patel, Alpa V.; Peters, Ulrike; Porta, Miquel; Real, Francisco ...; Rothman, Nathani ...; Sesso, Howard D.; Severi, Gianluca; Silverman, Debra; Strobel, Oliver; Sund, Malin; Thornquist, Mark ...; Tobias, Geoffrey ...; Wactawski-Wende, ...; Wareham, Nick; Weiderpass, Elis ...; Wentzensen, Nico ...; Wheeler, William; Yu, Herbert; Zeleniuch-Jacquo ...; Kraft, Peter; Li, Donghui; Jacobs, Eric J.; Petersen, Gloria ...; Wolpin, Brian M.; Risch, Harvey A.; Amundadottir, La ...; Yu, Kai; Klein, Alison P.; Stolzenberg-Solo ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Journal of the N ...

By the university: Umeå University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Subject headings

Keyword

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub