SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Glahn David C.)
 

Search: WFRF:(Glahn David C.) > Rare genetic varian...

Rare genetic variants explain missing heritability in smoking.

Jang, Seon-Kyeong (author)
University of Minnesota
Evans, Luke (author)
Fialkowski, Allison (author)
show more...
Arnett, Donna K (author)
Ashley-Koch, Allison E (author)
Barnes, Kathleen C (author)
Becker, Diane M (author)
Bis, Joshua C (author)
Blangero, John (author)
Bleecker, Eugene R (author)
Boorgula, Meher Preethi (author)
Bowden, Donald W (author)
Brody, Jennifer A (author)
Cade, Brian E (author)
Jenkins, Brenda W Campbell (author)
Carson, April P (author)
Chavan, Sameer (author)
Cupples, L Adrienne (author)
Custer, Brian (author)
Damrauer, Scott M (author)
David, Sean P (author)
de Andrade, Mariza (author)
Dinardo, Carla L (author)
Fingerlin, Tasha E (author)
Fornage, Myriam (author)
Freedman, Barry I (author)
Garrett, Melanie E (author)
Gharib, Sina A (author)
Glahn, David C (author)
Haessler, Jeffrey (author)
Heckbert, Susan R (author)
Hokanson, John E (author)
Hou, Lifang (author)
Hwang, Shih-Jen (author)
Hyman, Matthew C (author)
Judy, Renae (author)
Justice, Anne E (author)
Kaplan, Robert C (author)
Kardia, Sharon L R (author)
Kelly, Shannon (author)
Kim, Wonji (author)
Kooperberg, Charles (author)
Levy, Daniel (author)
Lloyd-Jones, Donald M (author)
Loos, Ruth J F (author)
Manichaikul, Ani W (author)
Gladwin, Mark T (author)
Martin, Lisa Warsinger (author)
Nouraie, Mehdi (author)
Melander, O. (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Meyers, Deborah A (author)
Montgomery, Courtney G (author)
North, Kari E (author)
Oelsner, Elizabeth C (author)
Palmer, Nicholette D (author)
Payton, Marinelle (author)
Peljto, Anna L (author)
Peyser, Patricia A (author)
Preuss, Michael (author)
Psaty, Bruce M (author)
Qiao, Dandi (author)
Rader, Daniel J (author)
Rafaels, Nicholas (author)
Redline, Susan (author)
Reed, Robert M (author)
Reiner, Alexander P (author)
Rich, Stephen S (author)
Rotter, Jerome I (author)
Schwartz, David A (author)
Shadyab, Aladdin H (author)
Silverman, Edwin K (author)
Smith, Nicholas L (author)
Smith, J. Gustav, 1982 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Smith, Albert V (author)
University of Minnesota
Smith, Jennifer A (author)
Tang, Weihong (author)
Taylor, Kent D (author)
Telen, Marilyn J (author)
Vasan, Ramachandran S (author)
Gordeuk, Victor R (author)
Wang, Zhe (author)
Wiggins, Kerri L (author)
Yanek, Lisa R (author)
Yang, Ivana V (author)
Young, Kendra A (author)
Young, Kristin L (author)
Zhang, Yingze (author)
Liu, Dajiang J (author)
Keller, Matthew C (author)
Vrieze, Scott (author)
show less...
 (creator_code:org_t)
et al 
2022-08-04
2022
English.
In: Nature human behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 6:11, s. 1577-1586
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability ([Formula: see text], 0.18-0.34). In the African ancestry samples, [Formula: see text] was estimated from 0.03 to 0.33 (s.e., 0.09-0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Find more in SwePub

By the author/editor
Jang, Seon-Kyeon ...
Evans, Luke
Fialkowski, Alli ...
Arnett, Donna K
Ashley-Koch, All ...
Barnes, Kathleen ...
show more...
Becker, Diane M
Bis, Joshua C
Blangero, John
Bleecker, Eugene ...
Boorgula, Meher ...
Bowden, Donald W
Brody, Jennifer ...
Cade, Brian E
Jenkins, Brenda ...
Carson, April P
Chavan, Sameer
Cupples, L Adrie ...
Custer, Brian
Damrauer, Scott ...
David, Sean P
de Andrade, Mari ...
Dinardo, Carla L
Fingerlin, Tasha ...
Fornage, Myriam
Freedman, Barry ...
Garrett, Melanie ...
Gharib, Sina A
Glahn, David C
Haessler, Jeffre ...
Heckbert, Susan ...
Hokanson, John E
Hou, Lifang
Hwang, Shih-Jen
Hyman, Matthew C
Judy, Renae
Justice, Anne E
Kaplan, Robert C
Kardia, Sharon L ...
Kelly, Shannon
Kim, Wonji
Kooperberg, Char ...
Levy, Daniel
Lloyd-Jones, Don ...
Loos, Ruth J F
Manichaikul, Ani ...
Gladwin, Mark T
Martin, Lisa War ...
Nouraie, Mehdi
Melander, O.
Meyers, Deborah ...
Montgomery, Cour ...
North, Kari E
Oelsner, Elizabe ...
Palmer, Nicholet ...
Payton, Marinell ...
Peljto, Anna L
Peyser, Patricia ...
Preuss, Michael
Psaty, Bruce M
Qiao, Dandi
Rader, Daniel J
Rafaels, Nichola ...
Redline, Susan
Reed, Robert M
Reiner, Alexande ...
Rich, Stephen S
Rotter, Jerome I
Schwartz, David ...
Shadyab, Aladdin ...
Silverman, Edwin ...
Smith, Nicholas ...
Smith, J. Gustav ...
Smith, Albert V
Smith, Jennifer ...
Tang, Weihong
Taylor, Kent D
Telen, Marilyn J
Vasan, Ramachand ...
Gordeuk, Victor ...
Wang, Zhe
Wiggins, Kerri L
Yanek, Lisa R
Yang, Ivana V
Young, Kendra A
Young, Kristin L
Zhang, Yingze
Liu, Dajiang J
Keller, Matthew ...
Vrieze, Scott
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature human beh ...
By the university
University of Gothenburg
Lund University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view