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New loci associated with kidney function and chronic kidney disease

Köttgen, Anna (author)
Pattaro, Cristian (author)
Böger, Carsten A. (author)
show more...
Fuchsberger, Christian (author)
Olden, Matthias (author)
Glazer, Nicole L. (author)
Parsa, Afshin (author)
Gao, Xiaoyi (author)
Yang, Qiong (author)
Smith, Albert V. (author)
O'Connell, Jeffrey R. (author)
Li, Man (author)
Schmidt, Helena (author)
Tanaka, Toshiko (author)
Isaacs, Aaron (author)
Ketkar, Shamika (author)
Hwang, Shih-Jen (author)
Johnson, Andrew D. (author)
Dehghan, Abbas (author)
Teumer, Alexander (author)
Pare, Guillaume (author)
Atkinson, Elizabeth J. (author)
Zeller, Tanja (author)
Lohman, Kurt (author)
Cornelis, Marilyn C. (author)
Probst-Hensch, Nicole M. (author)
Kronenberg, Florian (author)
Toenjes, Anke (author)
Hayward, Caroline (author)
Aspelund, Thor (author)
Eiriksdottir, Gudny (author)
Launer, Lenore J. (author)
Harris, Tamara B. (author)
Rampersaud, Evadnie (author)
Mitchell, Braxton D. (author)
Arking, Dan E. (author)
Boerwinkle, Eric (author)
Struchalin, Maksim (author)
Cavalieri, Margherita (author)
Singleton, Andrew (author)
Giallauria, Francesco (author)
Metter, Jeffrey (author)
de Boer, Ian H. (author)
Haritunians, Talin (author)
Lumley, Thomas (author)
Siscovick, David (author)
Psaty, Bruce M. (author)
Zillikens, M. Carola (author)
Oostra, Ben A. (author)
Feitosa, Mary (author)
Province, Michael (author)
de Andrade, Mariza (author)
Turner, Stephen T. (author)
Schillert, Arne (author)
Ziegler, Andreas (author)
Wild, Philipp S. (author)
Schnabel, Renate B. (author)
Wilde, Sandra (author)
Munzel, Thomas (author)
Leak, Tennille S. (author)
Illig, Thomas (author)
Klopp, Norman (author)
Meisinger, Christa (author)
Wichmann, H-Erich (author)
Koenig, Wolfgang (author)
Zgaga, Lina (author)
Zemunik, Tatijana (author)
Kolcic, Ivana (author)
Minelli, Cosetta (author)
Hu, Frank B. (author)
Johansson, Åsa (author)
Uppsala universitet,Institutionen för genetik och patologi
Igl, Wilmar (author)
Uppsala universitet,Institutionen för genetik och patologi
Zaboli, Ghazal (author)
Uppsala universitet,Institutionen för genetik och patologi
Wild, Sarah H. (author)
Wright, Alan F. (author)
Campbell, Harry (author)
Ellinghaus, David (author)
Schreiber, Stefan (author)
Aulchenko, Yurii S. (author)
Felix, Janine F. (author)
Rivadeneira, Fernando (author)
Uitterlinden, Andre G. (author)
Hofman, Albert (author)
Imboden, Medea (author)
Nitsch, Dorothea (author)
Brandstaetter, Anita (author)
Kollerits, Barbara (author)
Kedenko, Lyudmyla (author)
Maegi, Reedik (author)
Stumvoll, Michael (author)
Kovacs, Peter (author)
Boban, Mladen (author)
Campbell, Susan (author)
Endlich, Karlhans (author)
Voelzke, Henry (author)
Kroemer, Heyo K. (author)
Nauck, Matthias (author)
Voelker, Uwe (author)
Polasek, Ozren (author)
Vitart, Veronique (author)
Badola, Sunita (author)
Parker, Alexander N. (author)
Ridker, Paul M. (author)
Kardia, Sharon L. R. (author)
Blankenberg, Stefan (author)
Liu, Yongmei (author)
Curhan, Gary C. (author)
Franke, Andre (author)
Rochat, Thierry (author)
Paulweber, Bernhard (author)
Prokopenko, Inga (author)
Wang, Wei (author)
Gudnason, Vilmundur (author)
Shuldiner, Alan R. (author)
Coresh, Josef (author)
Schmidt, Reinhold (author)
Ferrucci, Luigi (author)
Shlipak, Michael G. (author)
van Duijn, Cornelia M. (author)
Borecki, Ingrid (author)
Kraemer, Bernhard K. (author)
Rudan, Igor (author)
Gyllensten, Ulf (author)
Uppsala universitet,Institutionen för genetik och patologi
Wilson, James F. (author)
Witteman, Jacqueline C. (author)
Pramstaller, Peter P. (author)
Rettig, Rainer (author)
Hastie, Nick (author)
Chasman, Daniel I. (author)
Kao, W. H. (author)
Heid, Iris M. (author)
Fox, Caroline S. (author)
show less...
 (creator_code:org_t)
2010-04-11
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:5, s. 376-384
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Keyword

MEDICINE
MEDICIN

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By the author/editor
Köttgen, Anna
Pattaro, Cristia ...
Böger, Carsten A ...
Fuchsberger, Chr ...
Olden, Matthias
Glazer, Nicole L ...
show more...
Parsa, Afshin
Gao, Xiaoyi
Yang, Qiong
Smith, Albert V.
O'Connell, Jeffr ...
Li, Man
Schmidt, Helena
Tanaka, Toshiko
Isaacs, Aaron
Ketkar, Shamika
Hwang, Shih-Jen
Johnson, Andrew ...
Dehghan, Abbas
Teumer, Alexande ...
Pare, Guillaume
Atkinson, Elizab ...
Zeller, Tanja
Lohman, Kurt
Cornelis, Marily ...
Probst-Hensch, N ...
Kronenberg, Flor ...
Toenjes, Anke
Hayward, Carolin ...
Aspelund, Thor
Eiriksdottir, Gu ...
Launer, Lenore J ...
Harris, Tamara B ...
Rampersaud, Evad ...
Mitchell, Braxto ...
Arking, Dan E.
Boerwinkle, Eric
Struchalin, Maks ...
Cavalieri, Margh ...
Singleton, Andre ...
Giallauria, Fran ...
Metter, Jeffrey
de Boer, Ian H.
Haritunians, Tal ...
Lumley, Thomas
Siscovick, David
Psaty, Bruce M.
Zillikens, M. Ca ...
Oostra, Ben A.
Feitosa, Mary
Province, Michae ...
de Andrade, Mari ...
Turner, Stephen ...
Schillert, Arne
Ziegler, Andreas
Wild, Philipp S.
Schnabel, Renate ...
Wilde, Sandra
Munzel, Thomas
Leak, Tennille S ...
Illig, Thomas
Klopp, Norman
Meisinger, Chris ...
Wichmann, H-Eric ...
Koenig, Wolfgang
Zgaga, Lina
Zemunik, Tatijan ...
Kolcic, Ivana
Minelli, Cosetta
Hu, Frank B.
Johansson, Åsa
Igl, Wilmar
Zaboli, Ghazal
Wild, Sarah H.
Wright, Alan F.
Campbell, Harry
Ellinghaus, Davi ...
Schreiber, Stefa ...
Aulchenko, Yurii ...
Felix, Janine F.
Rivadeneira, Fer ...
Uitterlinden, An ...
Hofman, Albert
Imboden, Medea
Nitsch, Dorothea
Brandstaetter, A ...
Kollerits, Barba ...
Kedenko, Lyudmyl ...
Maegi, Reedik
Stumvoll, Michae ...
Kovacs, Peter
Boban, Mladen
Campbell, Susan
Endlich, Karlhan ...
Voelzke, Henry
Kroemer, Heyo K.
Nauck, Matthias
Voelker, Uwe
Polasek, Ozren
Vitart, Veroniqu ...
Badola, Sunita
Parker, Alexande ...
Ridker, Paul M.
Kardia, Sharon L ...
Blankenberg, Ste ...
Liu, Yongmei
Curhan, Gary C.
Franke, Andre
Rochat, Thierry
Paulweber, Bernh ...
Prokopenko, Inga
Wang, Wei
Gudnason, Vilmun ...
Shuldiner, Alan ...
Coresh, Josef
Schmidt, Reinhol ...
Ferrucci, Luigi
Shlipak, Michael ...
van Duijn, Corne ...
Borecki, Ingrid
Kraemer, Bernhar ...
Rudan, Igor
Gyllensten, Ulf
Wilson, James F.
Witteman, Jacque ...
Pramstaller, Pet ...
Rettig, Rainer
Hastie, Nick
Chasman, Daniel ...
Kao, W. H.
Heid, Iris M.
Fox, Caroline S.
show less...
Articles in the publication
Nature Genetics
By the university
Uppsala University

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