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Exploring the genetics of lithium response in bipolar disorders.

Herrera-Rivero, Marisol (author)
Adli, Mazda (author)
Akiyama, Kazufumi (author)
show more...
Akula, Nirmala (author)
Amare, Azmeraw T (author)
Ardau, Raffaella (author)
Arias, Bárbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Bellivier, Frank (author)
Benabarre, Antonio (author)
Bengesser, Susanne (author)
Bhattacharjee, Abesh Kumar (author)
Biernacka, Joanna M (author)
Birner, Armin (author)
Cearns, Micah (author)
Cervantes, Pablo (author)
Chen, Hsi-Chung (author)
Chillotti, Caterina (author)
Karolinska Institutet
Cichon, Sven (author)
Clark, Scott R (author)
Colom, Francesc (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M (author)
Dalkner, Nina (author)
Degenhardt, Franziska (author)
Del Zompo, Maria (author)
DePaulo, J Raymond (author)
Etain, Bruno (author)
Falkai, Peter (author)
Ferensztajn-Rochowiak, Ewa (author)
Forstner, Andreas J (author)
Frank, Josef (author)
Frisén, Louise (author)
Karolinska Institutet
Frye, Mark A (author)
Fullerton, Janice M (author)
Gallo, Carla (author)
Gard, Sébastien (author)
Garnham, Julie S (author)
Goes, Fernando S (author)
Grigoroiu-Serbanescu, Maria (author)
Grof, Paul (author)
Hashimoto, Ryota (author)
Hasler, Roland (author)
Hauser, Joanna (author)
Heilbronner, Urs (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Hou, Liping (author)
Hsu, Yi-Hsiang (author)
Jamain, Stéphane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kato, Tadafumi (author)
Kelsoe, John (author)
Kittel-Schneider, Sarah (author)
Kuo, Po-Hsiu (author)
Kusumi, Ichiro (author)
König, Barbara (author)
Laje, Gonzalo (author)
Landén, Mikael, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Maj, Mario (author)
Manchia, Mirko (author)
Marie-Claire, Cynthia (author)
Martinsson, Lina (author)
Karolinska Institutet
McCarthy, Michael J (author)
McElroy, Susan L (author)
Millischer, Vincent (author)
Mitjans, Marina (author)
Mondimore, Francis M (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline M (author)
Novák, Tomas (author)
Nöthen, Markus M (author)
O'Donovan, Claire (author)
Ozaki, Norio (author)
Papiol, Sergi (author)
Pfennig, Andrea (author)
Pisanu, Claudia (author)
Potash, James B (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Richard-Lepouriel, Hélène (author)
Roberts, Gloria (author)
Rouleau, Guy A (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Schofield, Peter R (author)
Schubert, Klaus Oliver (author)
Schulte, Eva C (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D (author)
Shimoda, Katzutaka (author)
Simhandl, Christian (author)
Slaney, Claire M (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Streit, Fabian (author)
Tekola-Ayele, Fasil (author)
Thalamuthu, Anbupalam (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Veeh, Julia (author)
Vieta, Eduard (author)
Viswanath, Biju (author)
Witt, Stephanie H (author)
Zandi, Peter P (author)
Alda, Martin (author)
Bauer, Michael (author)
McMahon, Francis J (author)
Mitchell, Philip B (author)
Rietschel, Marcella (author)
Schulze, Thomas G (author)
Baune, Bernhard T (author)
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 (creator_code:org_t)
2023
English.
In: Research square.
  • Other publication (other academic/artistic)
Abstract Subject headings
Close  
  • Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N=2,064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II.We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism.Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Publication and Content Type

vet (subject category)
ovr (subject category)

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By the author/editor
Herrera-Rivero, ...
Adli, Mazda
Akiyama, Kazufum ...
Akula, Nirmala
Amare, Azmeraw T
Ardau, Raffaella
show more...
Arias, Bárbara
Aubry, Jean-Mich ...
Backlund, Lena
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Bhattacharjee, A ...
Biernacka, Joann ...
Birner, Armin
Cearns, Micah
Cervantes, Pablo
Chen, Hsi-Chung
Chillotti, Cater ...
Cichon, Sven
Clark, Scott R
Colom, Francesc
Cruceanu, Cristi ...
Czerski, Piotr M
Dalkner, Nina
Degenhardt, Fran ...
Del Zompo, Maria
DePaulo, J Raymo ...
Etain, Bruno
Falkai, Peter
Ferensztajn-Roch ...
Forstner, Andrea ...
Frank, Josef
Frisén, Louise
Frye, Mark A
Fullerton, Janic ...
Gallo, Carla
Gard, Sébastien
Garnham, Julie S
Goes, Fernando S
Grigoroiu-Serban ...
Grof, Paul
Hashimoto, Ryota
Hasler, Roland
Hauser, Joanna
Heilbronner, Urs
Herms, Stefan
Hoffmann, Per
Hou, Liping
Hsu, Yi-Hsiang
Jamain, Stéphane
Jiménez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kato, Tadafumi
Kelsoe, John
Kittel-Schneider ...
Kuo, Po-Hsiu
Kusumi, Ichiro
König, Barbara
Laje, Gonzalo
Landén, Mikael, ...
Lavebratt, Catha ...
Leboyer, Marion
Leckband, Susan ...
Maj, Mario
Manchia, Mirko
Marie-Claire, Cy ...
Martinsson, Lina
McCarthy, Michae ...
McElroy, Susan L
Millischer, Vinc ...
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Nievergelt, Caro ...
Novák, Tomas
Nöthen, Markus M
O'Donovan, Clair ...
Ozaki, Norio
Papiol, Sergi
Pfennig, Andrea
Pisanu, Claudia
Potash, James B
Reif, Andreas
Reininghaus, Eva
Richard-Lepourie ...
Roberts, Gloria
Rouleau, Guy A
Rybakowski, Janu ...
Schalling, Marti ...
Schofield, Peter ...
Schubert, Klaus ...
Schulte, Eva C
Schweizer, Barba ...
Severino, Giovan ...
Shekhtman, Tatya ...
Shilling, Paul D
Shimoda, Katzuta ...
Simhandl, Christ ...
Slaney, Claire M
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Streit, Fabian
Tekola-Ayele, Fa ...
Thalamuthu, Anbu ...
Tortorella, Alfo ...
Turecki, Gustavo
Veeh, Julia
Vieta, Eduard
Viswanath, Biju
Witt, Stephanie ...
Zandi, Peter P
Alda, Martin
Bauer, Michael
McMahon, Francis ...
Mitchell, Philip ...
Rietschel, Marce ...
Schulze, Thomas ...
Baune, Bernhard ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
By the university
University of Gothenburg
Karolinska Institutet

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