Skeletal muscle–derived cell implantation for the treatment of fecal incontinence: a randomized, placebo-controlled study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Graf Wilhelm) > Skeletal muscle–der...

Skeletal muscle–derived cell implantation for the treatment of fecal incontinence : a randomized, placebo-controlled study

Frudinger, Andrea (författare): Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria,Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria.;Med Univ Graz, Dept Obstet & Gynaecol, Div Gynaecol, Auenbruggerpl 14, A-8036 Graz, Austria

Gauruder-Burmester, Annett (författare): Interdisciplinary Pelvic Floor Center, Berlin, Germany,Interdisciplinary Pelv Floor Ctr, Berlin, Germany

Graf, Wilhelm (författare): Uppsala universitet,Gastrointestinalkirurgi,Akad Sjukhuset, Dept Surg, Uppsala, Sweden

visa fler...

Lehmann, Jan-Peter (författare): Department of Surgery, Östersunds Hospital, Östersund, Sweden,Östersunds Hosp, Dept Surg, Östersund, Sweden

Gunnarsson, Ulf (författare): Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden

Mihov, Minko (författare): Medical Center Unimed EOOD, Sevlievo, Bulgaria,Med Ctr Unimed EOOD, Sevlievo, Bulgaria

Ihnát, Peter (författare): Department of Surgical Studies, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic,Univ Ostrava, Fac Med, Dept Surg Studies, Ostrava, Czech Republic

Kosorok, Pavle (författare): Department of Proctology, Iatros Medical Centre, Ljubljana, Slovenia,Iatros Med Ctr, Dept Proctol, Ljubljana, Slovenia

Orhalmi, Julius (författare): Department of Surgery, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Prague, Czech Republic,Charles Univ Prague, Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Dept Surg, Prague, Czech Republic

Slauf, Petr (författare): Surgical Clinic 1, Faculty of Medicine, University Hospital Bulovka, Charles University, Prague, Czech Republic,Charles Univ Prague, Univ Hosp Bulovka, Fac Med, Surg Clin 1, Prague, Czech Republic

Emmanuel, Anton (författare): Gastrointestinal Physiology Unit, University College Hospital, London, United Kingdom,Univ Coll Hosp, Gastrointestinal Physiol Unit, London, England

Hristov, Vladislav (författare): Pirogov Hospital, Sofia, Bulgaria,Pirogov Hosp, Sofia, Bulgaria

Jungwirthova, Anna (författare): Department of Gastroenterology, St. Anna Clinic, Prague, Czech Republic,St Anna Clin, Dept Gastroenterol, Prague, Czech Republic

Lehur, Paul-Antoine (författare): Clinique de Chirurgie Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, University Hospital of Nantes, Nantes, France,Univ Hosp Nantes, Inst Malad Appareil Digest, Clin Chirurg Digest & Endocrinienne, Nantes, France

Müller, Andreas (författare): GastroZentrum Hirslanden, Klinik Hirslanden, Zürich, Switzerland

Amort, Melanie (författare): Innovacell AG, Innsbruck, Austria

Marksteiner, Rainer (författare): Innovacell AG, Innsbruck, Austria

Thurner, Marco (författare): Innovacell AG, Innsbruck, Austria

visa färre...

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria;Med Univ Graz, Dept Obstet & Gynaecol, Div Gynaecol, Auenbruggerpl 14, A-8036 Graz, Austria (creator_code:org_t)

Elsevier, 2023
2023
Engelska.
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 21:2, s. 476-486.e8

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background and Aims: Fecal incontinence (FI) improvement following injection of autologous skeletal muscle–derived cells has been previously suggested. This study aimed to test the efficacy and safety of said cells through a multicenter, placebo-controlled study, to determine an appropriate cell dose, and to delineate the target patient population that can most benefit from cell therapy.Methods: Patients experiencing FI for at least 6 months were randomized to receive a cell-free medium or low or high dose of cells. All patients received pelvic floor electrical stimulation before and after treatment. Incontinence episode frequency (IEF), FI quality of life, FI burden assessed on a visual analog scale, Wexner score, and parameters reflecting anorectal physiological function were all assessed for up to 12 months.Results: Cell therapy improved IEF, FI quality of life, and FI burden, reaching a preset level of statistical significance in IEF change compared with the control treatment. Post hoc exploratory analyses indicated that patients with limited FI duration and high IEF at baseline are most responsive to cells. Effects prevailed or increased in the high cell count group from 6 to 12 months but plateaued or diminished in the low cell count and control groups. Most physiological parameters remained unaltered. No unexpected adverse events were observed. Conclusions: Injection of a high dose of autologous skeletal muscle–derived cells followed by electrical stimulation significantly improved FI, particularly in patients with limited FI duration and high IEF at baseline, and could become a valuable tool for treatment of FI, subject to confirmatory phase 3 trial(s). (ClinicalTrialRegister.eu; EudraCT Number: 2010-021463-32).

Hitta via bibliotek

Clinical Gastroenterology and Hepatology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: Clinical Gastroe ...

Av lärosätet: Umeå universitet; Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Skeletal muscle–derived cell implantation for the treatment of fecal incontinence : a randomized, placebo-controlled study

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub