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Burden of hip fract...
Burden of hip fracture using disability-adjusted life-years: : a pooled analysis of prospective cohorts in the CHANCES consortium
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Papadimitriou, Nikos (författare)
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Tsilidis, Konstantinos K (författare)
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Orfanos, Philippos (författare)
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visa fler...
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Benetou, Vassiliki (författare)
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Ntzani, Evangelia E (författare)
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Soerjomataram, Isabelle (författare)
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Künn-Nelen, Annemarie (författare)
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- Pettersson-Kymmer, Ulrika (författare)
- Umeå universitet,Farmakologi
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- Eriksson, Sture (författare)
- Umeå universitet,Enheten för biobanksforskning
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Brenner, Hermann (författare)
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Schöttker, Ben (författare)
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Saum, Kai-Uwe (författare)
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Holleczek, Bernd (författare)
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Grodstein, Francine D (författare)
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Feskanich, Diane (författare)
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- Orsini, Nicola (författare)
- Karolinska Institutet
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- Wolk, Alicja (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi
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Bellavia, Andrea (författare)
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Wilsgaard, Tom (författare)
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Jørgensen, Lone (författare)
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Boffetta, Paolo (författare)
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Trichopoulos, Dimitrios (författare)
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Trichopoulou, Antonia (författare)
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: The Lancet Public health. - 2468-2667. ; 2:5, s. e239-e246
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: No studies have estimated disability-adjusted life-years (DALYs) lost due to hip fractures using real-life follow-up cohort data. We aimed to quantify the burden of disease due to incident hip fracture using DALYs in prospective cohorts in the CHANCES consortium, and to calculate population attributable fractions based on DALYs for specific risk factors.METHODS: We used data from six cohorts of participants aged 50 years or older at recruitment to calculate DALYs. We applied disability weights proposed by the National Osteoporosis Foundation and did a series of sensitivity analyses to examine the robustness of DALY estimates. We calculated population attributable fractions for smoking, body-mass index (BMI), physical activity, alcohol intake, type 2 diabetes and parity, use of hormone replacement therapy, and oral contraceptives in women. We calculated summary risk estimates across cohorts with pooled analysis and random-effects meta-analysis methods.FINDINGS: 223 880 men and women were followed up for a mean of 13 years (SD 6). 7724 (3·5%) participants developed an incident hip fracture, of whom 413 (5·3%) died as a result. 5964 DALYs (27 per 1000 individuals) were lost due to hip fractures, 1230 (20·6%) of which were in the group aged 75-79 years. 4150 (69·6%) DALYs were attributed to disability. Current smoking was the risk factor responsible for the greatest hip fracture burden (7·5%, 95% CI 5·2-9·7) followed by physical inactivity (5·5%, 2·1-8·5), history of diabetes (2·8%, 2·1-4·0), and low to average BMI (2·0%, 1·4-2·7), whereas low alcohol consumption (0·01-2·5 g per day) and high BMI had a protective effect.INTERPRETATION: Hip fracture can lead to a substantial loss of healthy life-years in elderly people. National public health policies should be strengthened to reduce hip fracture incidence and mortality. Primary prevention measures should be strengthened to prevent falls, and reduce smoking and a sedentary lifestyle.FUNDING: European Community's Seventh Framework Programme.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Papadimitriou, N ...
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Tsilidis, Konsta ...
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Orfanos, Philipp ...
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Benetou, Vassili ...
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Ntzani, Evangeli ...
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Soerjomataram, I ...
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visa fler...
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Künn-Nelen, Anne ...
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Pettersson-Kymme ...
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Eriksson, Sture
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Brenner, Hermann
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Schöttker, Ben
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Saum, Kai-Uwe
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Holleczek, Bernd
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Grodstein, Franc ...
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Feskanich, Diane
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Orsini, Nicola
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Wolk, Alicja
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Bellavia, Andrea
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Wilsgaard, Tom
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Jørgensen, Lone
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Boffetta, Paolo
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Trichopoulos, Di ...
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Trichopoulou, An ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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The Lancet Publ ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet