Sökning: WFRF:(Gunnarsson Rebeqa) >
IGHV3-21 Gene Frequ...
IGHV3-21 Gene Frequency in a Swedish Cohort of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia
-
- Cahill, Nicola, 1983- (författare)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
-
- Sutton, Lesley-Ann (författare)
- Uppsala universitet,Hematologi och immunologi,Molecular Haematology
-
- Jansson, Mattias (författare)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
-
visa fler...
-
- Murray, Fiona (författare)
- Uppsala universitet,Genomik
-
- Mansouri, Larry (författare)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
-
- Gunnarsson, Rebeqa (författare)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
-
- Ryan, Fergus (författare)
- Department of Biological Sciences, Institute of Technology, Dublin, Ireland
-
- Ekström-Smedby, Karin (författare)
- Karolinska Institutet,Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
-
- Geisler, Christian (författare)
- Department of Hematology, Leukemia Laboratory, Rigshospitalet, Copenhagen, Denmark
-
- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Laboratory Medicine, Stem Cell Center, Hematology and Transplantation, Lund University, Lund, Sweden
-
- Rosenquist, Richard (författare)
- Uppsala universitet,Hematologi och immunologi,Rosenquist Brandell
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
-
Ingår i: Clinical Lymphoma, Myeloma & Leukemia. - : Elsevier BV. - 2152-2650 .- 2152-2669. ; 12:3, s. 201-206
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The IGHV3-21 gene has been shown to be overrepresented in Scandinavian patients with chronic lymphocytic leukemia (CLL). By investigating a population-based cohort of 337 Swedish patients with CLL, a lower (6.5%) IGHV3-21 frequency was determined relative to our previous hospital-based studies (10.1%-12.7%), yet this frequency remained higher compared to other Western CLL cohorts (2.6%-4.1%). Furthermore, we confirmed the poor outcome for patients with IGHV3-21 to be independent of mutational and stereotypy status. Background: Scandinavian patients with CLL have shown an overrepresentation of the poor-prognostic IGHV3-21 gene. Furthermore, approximately 50% of patients with IGHV3-21 carry stereotyped B-cell receptors, which implicate antigen selection in leukemogenesis. These patients have also been reported to have shorter time to progression than patients with nonstereotyped IGHV3-21. Materials and Methods: To investigate the IGHV3-21 frequency and the clinical impact of IGHV3-21 stereotypy, 337 newly diagnosed Swedish CLL patients from a population-based cohort were analyzed. Results: Interestingly, the IGHV3-21 frequency was indeed lower (6.5%) in this indolent patient cohort than in our previous hospital-based cohort studies (10.1%-12.7%). Hence, a selection bias of more-aggressive cases rendered a higher proportion of IGHV3-21 cases in our original studies. Nevertheless, the Swedish IGHV3-21 frequency still remained higher when compared with other larger European or American studies (2.6%-4.1%). Finally, we confirmed the poor outcome for IGHV3-21 patients to be independent of mutational status and found stereotypy to have no impact on survival or time to treatment. Conclusion: The Swedish geographic bias in IGHV3-21 gene frequency was validated albeit at a lower frequency than previously reported. Moreover, no prognostic value could be attributed to IGHV3-21 stereotype status.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- IGHV3-21
- stereotypy
- Chronic lymphocytic leukemia
- Immunoglobulin heavy-chain variable 3 21 gene frequency
- Prognosis
- Stereotyped B-cell receptors
- Biology with specialization in Molecular Biology
- Biologi med inriktning mot molekylärbiologi
- Chronic lymphocytic leukemia
- Immunoglobulin heavy-chain variable 3 21
- gene frequency
- Prognosis
- Stereotyped B-cell receptors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cahill, Nicola, ...
-
Sutton, Lesley-A ...
-
Jansson, Mattias
-
Murray, Fiona
-
Mansouri, Larry
-
Gunnarsson, Rebe ...
-
visa fler...
-
Ryan, Fergus
-
Ekström-Smedby, ...
-
Geisler, Christi ...
-
Juliusson, Gunna ...
-
Rosenquist, Rich ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Clinical Lymphom ...
- Av lärosätet
-
Uppsala universitet
-
Lunds universitet
-
Karolinska Institutet