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Next generation pan...
Next generation pan-cancer blood proteome profiling using proximity extension assay
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- Alvez, Maria Bueno (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- Edfors, Fredrik (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- von Feilitzen, Kalle (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- Zwahlen, Martin (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- Mardinoglu, Adil (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, SE1 9RT, UK,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
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- Edqvist, Per Henrik (author)
- Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
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- Sjöblom, Tobias (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Lundin, Emma (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Rameika, Natallia (author)
- Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
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- Enblad, Gunilla (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Lindman, Henrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Höglund, Martin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Hesselager, Göran (author)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
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- Stålberg, Karin (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Uppsala Univ, Sweden
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- Enblad, Malin (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Univ, Sweden
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- Simonson, Oscar (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Univ, Sweden
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- Häggman, Michael (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Univ, Sweden
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- Axelsson, Tomas (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Dept Med Sci, Clin Chem & SciLifeLab Affin Prote, Uppsala, Sweden.
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- Åberg, Mikael (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk kemi,Uppsala Univ, Sweden
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- Nordlund, Jessica (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Zhong, Wen (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Science for Life Laboratory
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- Karlsson, Max (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- Gyllensten, Ulf B. (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
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- Ponten, Fredrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Fagerberg, Linn (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- peedq227, Per-Henrik D (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alvez, Maria Bue ...
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Edfors, Fredrik
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von Feilitzen, K ...
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Zwahlen, Martin
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Mardinoglu, Adil
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Edqvist, Per Hen ...
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show more...
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Sjöblom, Tobias
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Lundin, Emma
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Rameika, Natalli ...
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Enblad, Gunilla
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Lindman, Henrik
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Höglund, Martin
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Hesselager, Göra ...
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Stålberg, Karin
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Enblad, Malin
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Simonson, Oscar
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Häggman, Michael
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Axelsson, Tomas
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Åberg, Mikael
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Nordlund, Jessic ...
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Zhong, Wen
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Karlsson, Max
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Gyllensten, Ulf ...
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Ponten, Fredrik
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Fagerberg, Linn
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Uhlén, Mathias
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peedq227, Per-He ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Nature Communica ...
- By the university
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Royal Institute of Technology
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Uppsala University
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Linköping University
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Karolinska Institutet