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Genome-wide associa...
Genome-wide association study identifies five loci associated with lung function.
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Repapi, Emmanouela (author)
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Sayers, Ian (author)
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Wain, Louise V (author)
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show more...
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Burton, Paul R (author)
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Johnson, Toby (author)
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Obeidat, Ma'en (author)
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Zhao, Jing Hua (author)
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Ramasamy, Adaikalavan (author)
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Zhai, Guangju (author)
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Vitart, Veronique (author)
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Huffman, Jennifer E (author)
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- Igl, Wilmar (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Albrecht, Eva (author)
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Deloukas, Panos (author)
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Henderson, John (author)
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Granell, Raquel (author)
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McArdle, Wendy L (author)
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Rudnicka, Alicja R (author)
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Wellcome Trust Case Control Consortium, (author)
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Barroso, Inês (author)
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Loos, Ruth J F (author)
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Wareham, Nicholas J (author)
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Mustelin, Linda (author)
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Rantanen, Taina (author)
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Surakka, Ida (author)
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Imboden, Medea (author)
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Wichmann, H Erich (author)
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Grkovic, Ivica (author)
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Jankovic, Stipan (author)
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Zgaga, Lina (author)
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Hartikainen, Anna-Liisa (author)
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Peltonen, Leena (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Johansson, Åsa (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Zaboli, Ghazal (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Campbell, Harry (author)
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Wild, Sarah H (author)
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Wilson, James F (author)
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Gläser, Sven (author)
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Homuth, Georg (author)
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Völzke, Henry (author)
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Mangino, Massimo (author)
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Soranzo, Nicole (author)
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Spector, Tim D (author)
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Polasek, Ozren (author)
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Rudan, Igor (author)
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Wright, Alan F (author)
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Heliövaara, Markku (author)
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Ripatti, Samuli (author)
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Pouta, Anneli (author)
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Olin, Anna-Carin, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Torén, Kjell, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Cooper, Matthew N (author)
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James, Alan L (author)
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Palmer, Lyle J (author)
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Hingorani, Aroon D (author)
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Wannamethee, S Goya (author)
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Whincup, Peter H (author)
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Smith, George Davey (author)
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Ebrahim, Shah (author)
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McKeever, Tricia M (author)
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Pavord, Ian D (author)
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MacLeod, Andrew K (author)
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Morris, Andrew D (author)
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Porteous, David J (author)
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Cooper, Cyrus (author)
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Dennison, Elaine (author)
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Shaheen, Seif (author)
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Karrasch, Stefan (author)
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Schnabel, Eva (author)
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Schulz, Holger (author)
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Grallert, Harald (author)
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Bouatia-Naji, Nabila (author)
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Delplanque, Jérôme (author)
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Froguel, Philippe (author)
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Blakey, John D (author)
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NSHD Respiratory Study Team, (author)
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Britton, John R (author)
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Morris, Richard W (author)
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Holloway, John W (author)
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Lawlor, Debbie A (author)
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Hui, Jennie (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Jarvelin, Marjo-Riitta (author)
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Jackson, Cathy (author)
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Kähönen, Mika (author)
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Kaprio, Jaakko (author)
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Probst-Hensch, Nicole M (author)
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Koch, Beate (author)
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Hayward, Caroline (author)
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Evans, David M (author)
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Elliott, Paul (author)
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Strachan, David P (author)
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Hall, Ian P (author)
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Tobin, Martin D (author)
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(creator_code:org_t)
- 2009-12-13
- 2010
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:1, s. 36-44
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- lung function
- whole genome association
- genetic epidemiology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Repapi, Emmanoue ...
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Sayers, Ian
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Wain, Louise V
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Burton, Paul R
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Johnson, Toby
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Obeidat, Ma'en
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show more...
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Zhao, Jing Hua
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Ramasamy, Adaika ...
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Zhai, Guangju
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Vitart, Veroniqu ...
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Huffman, Jennife ...
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Igl, Wilmar
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Albrecht, Eva
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Deloukas, Panos
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Henderson, John
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Granell, Raquel
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McArdle, Wendy L
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Rudnicka, Alicja ...
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Wellcome Trust C ...
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Barroso, Inês
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Loos, Ruth J F
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Wareham, Nichola ...
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Mustelin, Linda
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Rantanen, Taina
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Surakka, Ida
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Imboden, Medea
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Wichmann, H Eric ...
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Grkovic, Ivica
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Jankovic, Stipan
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Zgaga, Lina
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Hartikainen, Ann ...
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Peltonen, Leena
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Gyllensten, Ulf
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Johansson, Åsa
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Zaboli, Ghazal
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Campbell, Harry
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Wild, Sarah H
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Wilson, James F
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Gläser, Sven
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Homuth, Georg
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Völzke, Henry
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Mangino, Massimo
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Soranzo, Nicole
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Spector, Tim D
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Polasek, Ozren
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Rudan, Igor
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Wright, Alan F
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Heliövaara, Mark ...
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Ripatti, Samuli
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Pouta, Anneli
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Torinsson Naluai ...
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Olin, Anna-Carin ...
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Torén, Kjell, 19 ...
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Cooper, Matthew ...
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James, Alan L
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Palmer, Lyle J
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Hingorani, Aroon ...
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Wannamethee, S G ...
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Whincup, Peter H
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Smith, George Da ...
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Ebrahim, Shah
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McKeever, Tricia ...
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Pavord, Ian D
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MacLeod, Andrew ...
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Morris, Andrew D
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Porteous, David ...
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Cooper, Cyrus
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Dennison, Elaine
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Shaheen, Seif
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Karrasch, Stefan
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Schnabel, Eva
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Schulz, Holger
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Grallert, Harald
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Bouatia-Naji, Na ...
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Delplanque, Jérô ...
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Froguel, Philipp ...
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Blakey, John D
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NSHD Respiratory ...
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Britton, John R
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Morris, Richard ...
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Holloway, John W
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Lawlor, Debbie A
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Hui, Jennie
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Nyberg, Fredrik, ...
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Jarvelin, Marjo- ...
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Jackson, Cathy
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Kähönen, Mika
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Kaprio, Jaakko
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Probst-Hensch, N ...
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Koch, Beate
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Hayward, Carolin ...
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Evans, David M
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Elliott, Paul
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Strachan, David ...
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Hall, Ian P
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Tobin, Martin D
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Uppsala University