Gene–gene interaction of AhR with and within the Wnt cascade affects susceptibility to lung cancer

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: onr:"swepub:oai:DiVA.org:umu-192772" > Gene–gene interacti...

1 av 1
Föregående post
Nästa post
Till träfflistan

Gene–gene interaction of AhR with and within the Wnt cascade affects susceptibility to lung cancer

Rosenberger, Albert (författare): Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institut Für Genetische Epidemiologie, Universitätsmedizin Göttingen, Humboldtallee 32, Göttingen, Germany

Muttray, Nils (författare): Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany

Hung, Rayjean J. (författare): Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, ON, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

visa fler...

Christiani, David C. (författare): Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/Harvard Medical School, MA, Boston, United States

Caporaso, Neil E. (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States

Liu, Geoffrey (författare): Medical Oncology and Medical Biophysics, Princess Margaret Cancer Centre, ON, Toronto, Canada; Medicine and Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada

Bojesen, Stig E. (författare): Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark

Le Marchand, Loic (författare): Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States

Albanes, Demetrios (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States

Aldrich, Melinda C. (författare): Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States

Tardon, Adonina (författare): Faculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain

Fernández-Tardón, Guillermo (författare): Faculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain

Rennert, Gad (författare): Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel

Field, John K. (författare): Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom

Davies, Michael P. A. (författare): Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom

Liloglou, Triantafillos (författare): Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom

Kiemeney, Lambertus A. (författare): Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, Netherlands

Lazarus, Philip (författare): Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States

Wendel, Bernadette (författare): Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany

Haugen, Aage (författare): National Institute of Occupational Health, Oslo, Norway

Zienolddiny, Shanbeh (författare): National Institute of Occupational Health, Oslo, Norway

Lam, Stephen (författare): British Columbia Cancer Agency, BC, Vancouver, Canada

Schabath, Matthew B. (författare): Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States

Andrew, Angeline S. (författare): Department of Epidemiology, Geisel School of Medicine, NH, Hanover, United States

Duell, Eric J. (författare): Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

Arnold, Susanne M. (författare): Markey Cancer Center, University of Kentucky, KY, Lexington, United States

Goodman, Gary E. (författare): Swedish Medical Group, WA, Seattle, United States

Chen, Chu (författare): Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, Seattle, United States

Doherty, Jennifer A. (författare): Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States

Taylor, Fiona (författare): Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

Cox, Angela (författare): Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

Woll, Penella J. (författare): Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

Risch, Angela (författare): University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria

Muley, Thomas R. (författare): Member of the German Center for Lung Research (DZL), Translational Lung Research Center (TLRC) Heidelberg, Heidelberg, Germany; Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany

Johansson, Mikael (författare): Umeå universitet,Onkologi

Brennan, Paul (författare): International Agency for Research on Cancer, World Health Organization, Lyon, France

Landi, Maria Teresa (författare): Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States

Shete, Sanjay S. (författare): Department of Biostatistics, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, TX, Houston, United States

Amos, Christopher I. (författare): Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States

Bickeböller, Heike (författare): Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany

visa färre...

(creator_code:org_t)

2022-01-31
2022
Engelska.
Ingår i: European Journal of Medical Research. - : BioMed Central (BMC). - 0949-2321 .- 2047-783X. ; 27:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://eurjmedres.b...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.Aim: To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.Methods: Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.Results: No genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278 SFRP4; OR = 1.20; 95% CI 1.13–1.27; p = 5.6 × 10–10) and never smokers (e.g., maker rs1133683 Axin2; OR = 1.27; 95% CI 1.19–1.35; p = 1.0 × 10–12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants.Conclusions: The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Association
Decision trees
Gene–gene integration
Never smoker
Polygenic risk score
Prediction
Small cell lung cancer
Susceptibility

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

European Journal of Medical Research (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Rosenberger, Alb ...; Muttray, Nils; Hung, Rayjean J.; Christiani, Davi ...; Caporaso, Neil E ...; Liu, Geoffrey; visa fler...; Bojesen, Stig E.; Le Marchand, Loi ...; Albanes, Demetri ...; Aldrich, Melinda ...; Tardon, Adonina; Fernández-Tardón ...; Rennert, Gad; Field, John K.; Davies, Michael ...; Liloglou, Triant ...; Kiemeney, Lamber ...; Lazarus, Philip; Wendel, Bernadet ...; Haugen, Aage; Zienolddiny, Sha ...; Lam, Stephen; Schabath, Matthe ...; Andrew, Angeline ...; Duell, Eric J.; Arnold, Susanne ...; Goodman, Gary E.; Chen, Chu; Doherty, Jennife ...; Taylor, Fiona; Cox, Angela; Woll, Penella J.; Risch, Angela; Muley, Thomas R.; Johansson, Mikae ...; Brennan, Paul; Landi, Maria Ter ...; Shete, Sanjay S.; Amos, Christophe ...; Bickeböller, Hei ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: European Journal ...

Av lärosätet: Umeå universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se