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Job strain and the risk of severe asthma exacerbations : a meta-analysis of individual-participant data from 100 000 European men and women

Heikkila, K. (författare)
Finnish Institute of Occupational Health, Uimalankatu 1, 33540 Tampere, Finland,Finnish Institute of Occupational Health, Helsinki, Finland
Madsen, I. E. H. (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark
Theorell, Töres (författare)
Stockholms universitet,Karolinska Institutet,Stressforskningsinstitutet,Enheten för epidemiologi
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Fransson, Eleonor (författare)
Karolinska Institutet,Jönköping University,Stockholms universitet,Stressforskningsinstitutet,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT
Westerlund, Hugo (författare)
Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Epidemiologi,Stress Research Institute, Stockholm University, Stockholm, Sweden
Westerholm, Peter J. M. (författare)
Uppsala universitet,Arbets- och miljömedicin
Virtanen, M. (författare)
Finnish Institute of Occupational Health, Uimalankatu 1, 33540 Tampere, Finland,Finnish Institute of Occupational Health, Helsinki, Finland
Vahtera, J. (författare)
Finnish Institute of Occupational Health, Turku, Finland; Department of Public Health, University of Turku, Turku, Finland
Vaananen, A. (författare)
Finnish Institute of Occupational Health, Uimalankatu 1, 33540 Tampere, Finland,Finnish Institute of Occupational Health, Helsinki, Finland
Theorell, Töres (författare)
Stockholms universitet,Stressforskningsinstitutet,Enheten för epidemiologi,Finnish Institute of Occupational Health, Turku, Finland
Suominen, S. B. (författare)
Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; Nordic School of Public Health, Göteborg, Sweden
Shipley, M. J. (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Salo, P. (författare)
Department of Public Health and Department of Psychology, University of Turku, Turku, Finland
Rugulies, R. (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health, Department of Psychology, University of Copenhagen, Copenhagen, Denmark
Pentti, J. (författare)
Pejtersen, J. H. (författare)
The Danish National Centre for Social Research, Copenhagen, Denmark
Oksanen, T. (författare)
Nordin, Maria (författare)
Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
Nielsen, M. L. (författare)
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Kouvonen, A. (författare)
School of Sociology Social Policy and Social Work, Queen's University Belfast, Belfast, United Kingdom,Finnish Institute of Occupational Health, Uimalankatu 1, 33540 Tampere, Finland,Finnish Institute of Occupational Health, Helsinki, Finland
Koskinen, A. (författare)
Koskenvuo, M. (författare)
Department of Public Health, University of Helsinki, Helsinki, Finland
Knutsson, Anders (författare)
Mittuniversitetet,Avdelningen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden
Ferrie, J. E. (författare)
Uppsala universitet,Arbets- och miljömedicin
Dragano, N. (författare)
Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany
Burr, H. (författare)
Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany
Borritz, M. (författare)
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Bjorner, J. B. (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark
Alfredsson, L. (författare)
Karolinska Institutet
Batty, G. D. (författare)
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom,Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
Singh-Manoux, A. (författare)
Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France
Kivimaki, M. (författare)
Finnish Institute of Occupational Health, Uimalankatu 1, 33540 Tampere, Finland,Finnish Institute of Occupational Health, Helsinki, Finland; Department of Epidemiology and Public Health, University College London, London, UK
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 (creator_code:org_t)
2014-04-12
2014
Engelska.
Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 69:6, s. 775-783
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BackgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women. MethodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses. ResultsDuring a median follow-up of 10years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code). In the age- and sex-adjusted analyses, job strain was associated with an increased risk of severe asthma exacerbations defined using the primary diagnostic code (hazard ratio, HR: 1.27, 95% confidence interval, CI: 1.00, 1.61). This association attenuated towards the null after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55). No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19). ConclusionsOur findings suggest that job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

asthma
exacerbation
job strain
psychosocial
work stress

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ref (ämneskategori)
art (ämneskategori)

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