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IL6 gene promoter p...
IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
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Huth, Cornelia (author)
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Heid, Iris M. (author)
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Vollmert, Caren (author)
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show more...
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Gieger, Christian (author)
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Grallert, Harald (author)
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Wolford, Johanna K. (author)
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Langer, Birgit (author)
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Thorand, Barbara (author)
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Klopp, Norman (author)
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Hamid, Yasmin H. (author)
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Pedersen, Oluf (author)
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Hansen, Torben (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Meisinger, Christa (author)
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Do?ring, Angela (author)
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Lo?wel, Hannelore (author)
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Lieb, Wolfgang (author)
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Hengstenberg, Christian (author)
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Rathmann, Wolfgang (author)
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Martin, Stephan (author)
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Stephens, Jeffrey W. (author)
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Ireland, Helen (author)
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Mather, Hugh (author)
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Miller, George J. (author)
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Stringham, Heather M. (author)
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Boehnke, Michael (author)
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Tuomilehto, Jaakko (author)
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Boeing, Heiner (author)
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Mo?hlig, Matthias (author)
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Spranger, Joachim (author)
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Pfeiffer, Andreas (author)
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- Wernstedt, Ingrid, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Niklason, Anders, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk prövning och entreprenörskap,Institute of Medicine, Department of Clinical Trials and Entrepreneurship
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Lo?pez-Bermejo, Abel (author)
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Fernández-Real, José-Manuel (author)
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Hanson, Robert L. (author)
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Gallart, Luis (author)
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Vendrell, Joan (author)
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Tsiavou, Anastasia (author)
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Hatziagelaki, Erifili (author)
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Humphries, Steve E. (author)
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Wichmann, H.-Erich (author)
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Herder, Christian (author)
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Illig, Thomas (author)
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Doring, Angela (author)
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Lowel, Hannelore (author)
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Lopez-Bermejo, Abel (author)
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(creator_code:org_t)
- American Diabetes Association, 2006
- 2006
- English.
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In: DIABETES. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:10, s. 2915-2921
- Related links:
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http://diabetes.diab...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, −174G>C (rs1800795) and −573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 −174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 −573G>C and type 2 diabetes. The observed association of the IL6 −174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- body-mass index
- interleukin-6 gene
- tnf-alpha
- -174 g/c
- metaanalysis
- mellitus
- il-6
- association
- c-174g
- plasma
Publication and Content Type
- ref (subject category)
- art (subject category)
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DIABETES
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To the university's database
- By the author/editor
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Huth, Cornelia
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Heid, Iris M.
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Vollmert, Caren
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Gieger, Christia ...
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Grallert, Harald
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Wolford, Johanna ...
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show more...
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Langer, Birgit
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Thorand, Barbara
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Klopp, Norman
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Hamid, Yasmin H.
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Pedersen, Oluf
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Hansen, Torben
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Lyssenko, Valeri ...
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Groop, Leif
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Meisinger, Chris ...
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Do?ring, Angela
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Lo?wel, Hannelor ...
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Lieb, Wolfgang
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Hengstenberg, Ch ...
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Rathmann, Wolfga ...
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Martin, Stephan
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Stephens, Jeffre ...
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Ireland, Helen
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Mather, Hugh
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Miller, George J ...
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Stringham, Heath ...
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Boehnke, Michael
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Tuomilehto, Jaak ...
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Boeing, Heiner
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Mo?hlig, Matthia ...
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Spranger, Joachi ...
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Pfeiffer, Andrea ...
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Wernstedt, Ingri ...
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Niklason, Anders ...
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Lo?pez-Bermejo, ...
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Fernández-Real, ...
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Hanson, Robert L ...
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Gallart, Luis
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Vendrell, Joan
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Tsiavou, Anastas ...
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Hatziagelaki, Er ...
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Humphries, Steve ...
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Wichmann, H.-Eri ...
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Herder, Christia ...
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Illig, Thomas
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Doring, Angela
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Lowel, Hannelore
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Lopez-Bermejo, A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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DIABETES
- By the university
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University of Gothenburg
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Lund University