Tyck till om SwePub Sök här!
WFRF:(Hickie IB)
Search: WFRF:(Hickie IB) > Genome-wide by envi...
- 2 of 22
- Previous record
- Next record
- To hitlist
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
- Arnau-Soler, A (author)
- Macdonald-Dunlop, E (author)
- Adams, MJ (author)
- show more...
- Clarke, TK (author)
- MacIntyre, DJ (author)
- Milburn, K (author)
- Navrady, L (author)
- Hayward, C (author)
- McIntosh, AM (author)
- Thomson, PA (author)
- Wray, NR (author)
- Ripke, S (author)
- Trzaskowski, M (author)
- Byrne, EM (author)
- Abdellaoui, A (author)
- Agerbo, E (author)
- Air, TM (author)
- Andlauer, TFM (author)
- Bacanu, SA (author)
- Baekvad-Hansen, M (author)
- Beekman, ATF (author)
- Bigdeli, TB (author)
- Binder, EB (author)
- Blackwood, DHR (author)
- Buttenscon, HN (author)
- Bybjerg-Grauholm, J (author)
- Cai, N (author)
- Castelao, E (author)
- Christensen, JH (author)
- Coleman, JRI (author)
- Colodro-Conde, L (author)
- Couvy-Duchesne, B (author)
- Craddock, N (author)
- Rawford, GEC (author)
- Davies, G (author)
- Deary, IJ (author)
- Degenhardt, F (author)
- Derks, EM (author)
- Direk, N (author)
- Dolan, CV (author)
- Dunn, EC (author)
- Eley, TC (author)
- Escott-Price, V (author)
- Kiadeh, FFH (author)
- Finucane, HK (author)
- Foo, JC (author)
- Forstner, AJ (author)
- Frank, J (author)
- Gaspar, HA (author)
- Gill, M (author)
- Goes, FS (author)
- Gordon, SD (author)
- Grove, J (author)
- Hall, LS (author)
- Hansen, CS (author)
- Hansen, TF (author)
- Herms, S (author)
- Hickie, IB (author)
- Hoffmann, P (author)
- Homuth, G (author)
- Horn, C (author)
- Hottenga, JJ (author)
- Hougaard, DM (author)
- Ising, M (author)
- Jansen, R (author)
- Jones, I (author)
- Jones, LA (author)
- Jorgenson, E (author)
- Knowles, JA (author)
- Kohane, IS (author)
- Kraft, J (author)
- Kretzschmar, WW (author)
- Krogh, J (author)
- Kutalik, Z (author)
- Li, YH (author)
- Lind, PA (author)
- Macintyre, DJ (author)
- MacKinnon, DF (author)
- Maier, RM (author)
- Maier, W (author)
- Marchini, J (author)
- Mbarek, H (author)
- McGrath, P (author)
- McGuffin, P (author)
- Medland, SE (author)
- Mehta, D (author)
- Middeldorp, CM (author)
- Mihailov, E (author)
- Milaneschi, Y (author)
- Milani, L (author)
- Mondimore, FM (author)
- Montgomery, GW (author)
- Mostafavi, S (author)
- Mullins, N (author)
- Nauck, M (author)
- Ng, B (author)
- Nivard, MG (author)
- Nyholt, DR (author)
- O'Reilly, PF (author)
- Oskarsson, H (author)
- Owen, MJ (author)
- Painter, JN (author)
- Pedersen, CB (author)
- Pedersen, MG (author)
- Peterson, RE (author)
- Peyrot, WJ (author)
- Pistis, G (author)
- Posthuma, D (author)
- Quiroz, JA (author)
- Qvist, P (author)
- Rice, JP (author)
- Riley, BP (author)
- Rivera, M (author)
- Mirza, SS (author)
- Schoevers, R (author)
- Schulte, EC (author)
- Shen, L (author)
- Shi, JX (author)
- Shyn, SI (author)
- Sigurdsson, E (author)
- Sinnamon, GCB (author)
- Smit, JH (author)
- Smith, DJ (author)
- Stefansson, H (author)
- Steinberg, S (author)
- Streit, F (author)
- Strohmaier, J (author)
- Tansey, KE (author)
- Teismann, H (author)
- Teumer, A (author)
- Thompson, W (author)
- Thorgeirsson, TE (author)
- Traylor, M (author)
- Treutlein, J (author)
- Trubetskoy, V (author)
- Uitterlinden, AG (author)
- Umbricht, D (author)
- Van der Auwera, S (author)
- van Hemert, AM (author)
- Visscher, PM (author)
- Wang, YP (author)
- Webb, BT (author)
- Weinsheimer, SM (author)
- Wellmann, J (author)
- Willemsen, G (author)
- Witt, SH (author)
- Wu, Y (author)
- Xi, HLS (author)
- Yang, J (author)
- Zhang, FT (author)
- Arolt, V (author)
- Baune, BT (author)
- Berger, K (author)
- Boomsma, DI (author)
- Cichon, S (author)
- Dannlowski, U (author)
- de Geus, EJC (author)
- DePaulo, JR (author)
- Domenici, E (author)
- Domschke, K (author)
- Esko, T (author)
- Grabe, HJ (author)
- Hamilton, SP (author)
- Heath, AC (author)
- Kendler, KS (author)
- Kloiber, S (author)
- Lewis, G (author)
- Li, QQS (author)
- Lucae, S (author)
- Madden, PAF (author)
- Martin, NG (author)
- Metspalu, A (author)
- Mors, O (author)
- Mortensen, PB (author)
- Muller-Myhsok, B (author)
- Nordentoft, M (author)
- Nothen, MM (author)
- O'Donovan, MC (author)
- Paciga, SA (author)
- Penninx, BWJH (author)
- Perlis, RH (author)
- Porteous, DJ (author)
- Potash, JB (author)
- Preisig, M (author)
- Rietschel, M (author)
- Schaefer, C (author)
- Schulze, TG (author)
- Smoller, JW (author)
- Stefansson, K (author)
- Tiemeier, H (author)
- Uher, R (author)
- Volzke, H (author)
- Weissman, MM (author)
- Werge, T (author)
- Lewis, CM (author)
- Levinson, DF (author)
- Breen, G (author)
- Borglum, ASD (author)
- show less...
- (creator_code:org_t)
- 2019-02-04
- 2019
- English.
- In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 14-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10−6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 × 10−9; total SLE) and rs17070072 (intronic to ZCCHC2; p = 1.46 × 10−8; dependent SLE). A third locus upstream CYLC2 (rs12000047 and rs12005200, p < 2.00 × 10−8; dependent SLE) when the joint effect of the SNP main and GxE effects was considered. GWEIS gene-based tests identified: MTNR1B with GxE effect with dependent SLE in Generation Scotland; and PHF2 with the joint effect in UK Biobank (p < 2.77 × 10−6). Polygenic risk scores (PRSs) analyses incorporating GxE effects improved the prediction of depressive symptom scores, when using weights derived from either the UK Biobank GWAS of depressive symptoms (p = 0.01) or the PGC GWAS of major depressive disorder (p = 5.91 × 10−3). Using an independent sample, PRS derived using GWEIS GxE effects provided evidence of shared aetiologies between depressive symptoms and schizotypal personality, heart disease and COPD. Further such studies are required and may result in improved treatments for depression and other stress-related conditions.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Translational psychiatry (Search for host publication in LIBRIS)
To the university's database
- 2 of 22
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Arnau-Soler, A
- Macdonald-Dunlop ...
- Adams, MJ
- Clarke, TK
- MacIntyre, DJ
- Milburn, K
- show more...
- Navrady, L
- Hayward, C
- McIntosh, AM
- Thomson, PA
- Wray, NR
- Ripke, S
- Mattheisen, M
- Trzaskowski, M
- Byrne, EM
- Abdellaoui, A
- Agerbo, E
- Air, TM
- Andlauer, TFM
- Bacanu, SA
- Baekvad-Hansen, ...
- Beekman, ATF
- Bigdeli, TB
- Binder, EB
- Blackwood, DHR
- Bryois, J
- Buttenscon, HN
- Bybjerg-Grauholm ...
- Cai, N
- Castelao, E
- Christensen, JH
- Coleman, JRI
- Colodro-Conde, L
- Couvy-Duchesne, ...
- Craddock, N
- Rawford, GEC
- Davies, G
- Deary, IJ
- Degenhardt, F
- Derks, EM
- Direk, N
- Dolan, CV
- Dunn, EC
- Eley, TC
- Escott-Price, V
- Kiadeh, FFH
- Finucane, HK
- Foo, JC
- Forstner, AJ
- Frank, J
- Gaspar, HA
- Gill, M
- Goes, FS
- Gordon, SD
- Grove, J
- Hall, LS
- Hansen, CS
- Hansen, TF
- Herms, S
- Hickie, IB
- Hoffmann, P
- Homuth, G
- Horn, C
- Hottenga, JJ
- Hougaard, DM
- Ising, M
- Jansen, R
- Jones, I
- Jones, LA
- Jorgenson, E
- Knowles, JA
- Kohane, IS
- Kraft, J
- Kretzschmar, WW
- Krogh, J
- Kutalik, Z
- Li, YH
- Lind, PA
- Macintyre, DJ
- MacKinnon, DF
- Maier, RM
- Maier, W
- Marchini, J
- Mbarek, H
- McGrath, P
- McGuffin, P
- Medland, SE
- Mehta, D
- Middeldorp, CM
- Mihailov, E
- Milaneschi, Y
- Milani, L
- Mondimore, FM
- Montgomery, GW
- Mostafavi, S
- Mullins, N
- Nauck, M
- Ng, B
- Nivard, MG
- Nyholt, DR
- O'Reilly, PF
- Oskarsson, H
- Owen, MJ
- Painter, JN
- Pedersen, CB
- Pedersen, MG
- Peterson, RE
- Pettersson, E
- Peyrot, WJ
- Pistis, G
- Posthuma, D
- Quiroz, JA
- Qvist, P
- Rice, JP
- Riley, BP
- Rivera, M
- Mirza, SS
- Schoevers, R
- Schulte, EC
- Shen, L
- Shi, JX
- Shyn, SI
- Sigurdsson, E
- Sinnamon, GCB
- Smit, JH
- Smith, DJ
- Stefansson, H
- Steinberg, S
- Streit, F
- Strohmaier, J
- Tansey, KE
- Teismann, H
- Teumer, A
- Thompson, W
- Thorgeirsson, TE
- Traylor, M
- Treutlein, J
- Trubetskoy, V
- Uitterlinden, AG
- Umbricht, D
- Van der Auwera, ...
- van Hemert, AM
- Viktorin, A
- Visscher, PM
- Wang, YP
- Webb, BT
- Weinsheimer, SM
- Wellmann, J
- Willemsen, G
- Witt, SH
- Wu, Y
- Xi, HLS
- Yang, J
- Zhang, FT
- Arolt, V
- Baune, BT
- Berger, K
- Boomsma, DI
- Cichon, S
- Dannlowski, U
- de Geus, EJC
- DePaulo, JR
- Domenici, E
- Domschke, K
- Esko, T
- Grabe, HJ
- Hamilton, SP
- Heath, AC
- Kendler, KS
- Kloiber, S
- Lewis, G
- Li, QQS
- Lucae, S
- Madden, PAF
- Magnusson, PK
- Martin, NG
- Metspalu, A
- Mors, O
- Mortensen, PB
- Muller-Myhsok, B
- Nordentoft, M
- Nothen, MM
- O'Donovan, MC
- Paciga, SA
- Pedersen, NL
- Penninx, BWJH
- Perlis, RH
- Porteous, DJ
- Potash, JB
- Preisig, M
- Rietschel, M
- Schaefer, C
- Schulze, TG
- Smoller, JW
- Stefansson, K
- Tiemeier, H
- Uher, R
- Volzke, H
- Weissman, MM
- Werge, T
- Lewis, CM
- Levinson, DF
- Breen, G
- Borglum, ASD
- Sullivan, PF
- show less...
- Articles in the publication
- Translational ps ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
