Search: WFRF:(Hillert Jan) >
Predictors of patie...
Predictors of patient-reported fatigue symptom severity in a nationwide multiple sclerosis cohort
-
- Englund, Simon (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Kierkegaard, Marie (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
-
- Burman, Joachim, 1974- (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
-
show more...
-
- Fink, Katharina (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Fogdell-Hahn, Anna (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Gunnarsson, Martin, 1973- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Fac Med & Hlth, Dept Neurol, Orebro, Sweden.
-
- Hillert, Jan (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Langer-Gould, Annette (author)
- Clinical and Translational Neuroscience, Southern California Permanente Medical Group, Kaiser Permanente, Pasadena, United States,Kaiser Permanente, Southern Calif Permanente Med Grp, Clin & Translat Neurosci, Pasadena, CA USA.
-
- Lycke, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
-
- Nilsson, Petra (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
-
- Salzer, Jonatan (author)
- Umeå University,Umeå universitet,Neurovetenskaper,Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden.
-
- Svenningsson, Anders (author)
- Karolinska Institutet,Danderyd Hosp Stockholm, Clin Sci, Stockholm, Sweden.,Danderyd Hospital
-
- Mellergård, Johan (author)
- Linköpings universitet,Linköping University,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
-
- Olsson, Tomas (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Longinetti, Elisa (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
-
- Frisell, Thomas (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
-
- Piehl, Fredrik (author)
- Karolinska Institute,Karolinska Inst, Sweden
-
show less...
-
Karolinska Institutet Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
-
In: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 70
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Fatigue is a debilitating symptom of multiple sclerosis (MS), but its relation to sociodemographic and disease-related characteristics has not been investigated in larger studies. The objectives of this study were to evaluate predictors of self-reported fatigue in a Swedish nationwide register-based MS cohort.METHODS: Using a repeated cross-sectional design, we included 2,165 persons with relapsing- remitting and secondary progressive MS with one or multiple Fatigue Scale for Motor and Cognitive Functions (FSMC) scores, which was modelled using multivariable linear regressions for multiple predictors.RESULTS: Only associations to expanded disability status scale (EDSS) and Symbol Digit Modalities Test (SDMT) were considered clinically meaningful among MS-associated characteristics in our main model; compared to mild disability (EDSS 0-2.5), those with severe disability (EDSS ≥6) scored 17.6 (95% CI 13.1-22.2) FSMC points higher, while the difference was 10.7 (95% CI 8.0-13.4) points for the highest and lowest quartiles of SDMT. Differences between highest and lowest quartiles of health-related quality of life (HRQoL) instruments were even greater and considered clinically meaningful; EuroQoL Visual Analogue Scale (EQ-VAS) 31.9 (95% CI 29.9-33.8), Multiple Sclerosis Impact Scale (MSIS-29) psychological component 35.6 (95% CI 33.8-37.4) and MSIS-29 physical component 45.5 (95% CI 43.7-47.4).CONCLUSION: Higher self-reported fatigue is associated with higher disability level and worse cognitive processing speed, while associations to other MS-associated characteristics including MS type, line of disease modifying therapy (DMT), MS duration, relapse and new cerebral lesions are weak. Furthermore, we found a strong correlation between high fatigue rating and lower ratings on health-related quality of life instruments.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cohort studies
- Comorbidity
- Fatigue
- Health-related quality of life
- Multiple sclerosis
- Quality of life
- Cohort studies
- Comorbidity
- Fatigue
- Health-related quality of life
- Multiple sclerosis
- Quality of life
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Englund, Simon
-
Kierkegaard, Mar ...
-
Burman, Joachim, ...
-
Fink, Katharina
-
Fogdell-Hahn, An ...
-
Gunnarsson, Mart ...
-
show more...
-
Hillert, Jan
-
Langer-Gould, An ...
-
Lycke, Jan, 1956
-
Nilsson, Petra
-
Salzer, Jonatan
-
Svenningsson, An ...
-
Mellergård, Joha ...
-
Olsson, Tomas
-
Longinetti, Elis ...
-
Frisell, Thomas
-
Piehl, Fredrik
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Multiple Scleros ...
- By the university
-
Örebro University
-
Umeå University
-
Karolinska Institutet
-
Uppsala University
-
Lund University
-
Linköping University
-
show more...
-
University of Gothenburg
-
show less...