Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Lai, Heidi T. M. (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.

Imamura, Fumiaki (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

Korat, Andres V. Ardisson (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

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Murphy, Rachel A. (författare): Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada.

Tintle, Nathan (författare): Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.;Fatty Acid Res Inst, Sioux Falls, SD USA.

Bassett, Julie K. (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.

Chen, Jiaying (författare): Brigham & Womens Hosp, Div Aging, Boston, MA USA.

Kröger, Janine (författare): German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.

Chien, Kuo-Liong (författare): Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.

Senn, Mackenzie (författare): ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.

Wood, Alexis C. (författare): ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.

Forouhi, Nita G. (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

Schulze, Matthias B. (författare): German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.

Harris, William S. (författare): Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.

Vasan, Ramachandran S. (författare): Boston Univ, Sch Med, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.

Hu, Frank (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Giles, Graham G. (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.

Hodge, Allison (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.

Djousse, Luc (författare): Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA USA.

Brouwer, Ingeborg A. (författare): Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.

Qian, Frank (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.

Sun, Qi (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Wu, Jason H. Y. (författare): Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.

Marklund, Matti (författare): Uppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA; Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia

Lemaitre, Rozenn N. (författare): Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.

Siscovick, David S. (författare): New York Acad Med, New York, NY USA.

Fretts, Amanda M. (författare): Univ Washington, Dept Epidemiol, Sch Publ Hlth, Cardiovasc Hlth Res Unit, Seattle, WA USA.

Shadyab, Aladdin H. (författare): Univ Calif San Diego, Sch Med, Family Med & Publ Hlth, La Jolla, CA 92093 USA.

Manson, JoAnn E. (författare): Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.

Howard, Barbara, V (författare): Georgetown Univ, Med Ctr, Hyattsville, MD USA.

Robinson, Jennifer G. (författare): Univ Iowa, Iowa City, IA USA.

Wallace, Robert B. (författare): Univ Iowa, Iowa City, IA USA.

Wareham, Nick J. (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

Chen, Yii-Der Ida (författare): Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.

Rotter, Jerome, I (författare): Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.

Tsai, Michael Y. (författare): Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.

Micha, Renata (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.

Mozaffarian, Dariush (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.

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Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England. Univ Cambridge, MRC Epidemiol Unit, Cambridge, England. (creator_code:org_t)

2022-02-10
2022
Engelska.
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 45:4, s. 854-863

Relaterad länk:: https://diabetesjour...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.2...; visa färre...

Tidskriftsartikel (refereegranskat)

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OBJECTIVE: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS: We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged >= 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.RESULTS: During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P >= 0.1).CONCLUSIONS: Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

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