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Sökning: onr:"swepub:oai:DiVA.org:umu-214758" > Genome-wide interac...

Genome-wide interaction analysis of folate for colorectal cancer risk

Bouras, Emmanouil (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Kim, Andre E. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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Morrison, John (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Du, Mengmeng (författare)
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, New York, United States
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Barry, Elizabeth L. (författare)
Department of Epidemiology, Geisel School of Medicine at Dartmouth, NH, Hanover, United States
Baurley, James W. (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Bien, Stephanie A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Bishop, Timothy D. (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Budiarto, Arif (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Carreras-Torres, Robert (författare)
Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Cenggoro, Tjeng Wawan (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Conti, David V. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Cotterchio, Michelle (författare)
Ontario Health (Cancer Care Ontario), ON, Toronto, Canada
Devall, Matthew (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States; Department of Public Health Sciences, Center for Public Health Genomics, VA, Charlottesville, United States
Diez-Obrero, Virginia (författare)
Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Drew, David A. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hidaka, Akihisa (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Joshi, Amit D. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
Kawaguchi, Eric S. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, Los Angeles, United States
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Lewinger, Juan Pablo (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Lynch, Brigid M. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Mahesworo, Bharuno (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Männistö, Satu (författare)
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
Moreno, Victor (författare)
Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
Obón-Santacana, Mireia (författare)
Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ose, Jennifer (författare)
Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Palmer, Julie R. (författare)
Slone Epidemiology Center at Boston University, MA, Boston, United States
Papadimitriou, Nikos (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Pellatt, Andrew J. (författare)
Department of Cancer Medicine, MD Anderson Cancer Center, TX, Houston, United States
Peoples, Anita R. (författare)
Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Qi, Lihong (författare)
Department of Public Health Sciences, University of California Davis, CA, Davis, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Ruiz-Narvaez, Edward (författare)
Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Schmit, Stephanie L. (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States
Shcherbina, Anna (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Stern, Mariana C. (författare)
Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Tangen, Catherine M. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Thomas, Duncan C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Tian, Yu (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
Um, Caroline Y. (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
van Duijnhoven, Franzel JB. (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Wang, Jun (författare)
Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Wolk, Alicja (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St John's, Canada
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Gauderman, W James (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Tsilidis, Konstantinos K. (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
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 (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: American Journal of Clinical Nutrition. - : Elsevier. - 0002-9165 .- 1938-3207. ; 118:5, s. 881-891
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC.Objectives: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk.Methods: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO).Results: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate.Conclusions: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

colorectal cancer
CRC
European
folate
folic acid
genome-wide
GWIS
interaction
SYN2
synapsin
TIMP4
tissue inhibitor of metalloproteinase 4

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Bouras, Emmanoui ...
Kim, Andre E.
Lin, Yi
Morrison, John
Du, Mengmeng
Albanes, Demetri ...
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Barry, Elizabeth ...
Baurley, James W ...
Berndt, Sonja I.
Bien, Stephanie ...
Bishop, Timothy ...
Brenner, Hermann
Budiarto, Arif
Burnett-Hartman, ...
Campbell, Peter ...
Carreras-Torres, ...
Casey, Graham
Cenggoro, Tjeng ...
Chan, Andrew T.
Chang-Claude, Je ...
Conti, David V.
Cotterchio, Mich ...
Devall, Matthew
Diez-Obrero, Vir ...
Dimou, Niki
Drew, David A.
Figueiredo, Jane ...
Giles, Graham G.
Gruber, Stephen ...
Gunter, Marc J.
Harrison, Tabith ...
Hidaka, Akihisa
Hoffmeister, Mic ...
Huyghe, Jeroen R ...
Joshi, Amit D.
Kawaguchi, Eric ...
Keku, Temitope O ...
Kundaje, Anshul
Le Marchand, Loi ...
Lewinger, Juan P ...
Li, Li
Lynch, Brigid M.
Mahesworo, Bharu ...
Männistö, Satu
Moreno, Victor
Murphy, Neil
Newcomb, Polly A ...
Obón-Santacana, ...
Ose, Jennifer
Palmer, Julie R.
Papadimitriou, N ...
Pardamean, Bens
Pellatt, Andrew ...
Peoples, Anita R ...
Platz, Elizabeth ...
Potter, John D.
Qi, Lihong
Qu, Conghui
Rennert, Gad
Ruiz-Narvaez, Ed ...
Sakoda, Lori C.
Schmit, Stephani ...
Shcherbina, Anna
Stern, Mariana C ...
Su, Yu-Ru
Tangen, Catherin ...
Thomas, Duncan C ...
Tian, Yu
Um, Caroline Y.
van Duijnhoven, ...
van Guelpen, Bet ...
Visvanathan, Kal ...
Wang, Jun
White, Emily
Wolk, Alicja
Woods, Michael O ...
Ulrich, Cornelia ...
Hsu, Li
Gauderman, W Jam ...
Peters, Ulrike
Tsilidis, Konsta ...
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