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Bivariate genome-wi...
Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits
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- Haljas, Kadri (författare)
- University of Helsinki
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- Amare, Azmeraw T. (författare)
- University Medical Center Groningen,University of Groningen
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- Alizadeh, Behrooz Z. (författare)
- University of Groningen,University Medical Center Groningen
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- Hsu, Yi Hsiang (författare)
- Harvard University
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- Mosley, Thomas (författare)
- University of Mississippi Medical Center,University of Mississippi
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- Newman, Anne (författare)
- University of Pittsburgh
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- Murabito, Joanne (författare)
- National Heart Lung and Blood Institute,Boston University
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- Tiemeier, Henning (författare)
- Erasmus University Medical Center,Erasmus University Rotterdam
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- Tanaka, Toshiko (författare)
- National Institute on Aging, United States
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- Van Duijn, Cornelia (författare)
- Erasmus University Rotterdam,Centre for Medical Systems Biology, Leiden,Erasmus University Medical Center
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- Ding, Jingzhong (författare)
- Wake Forest University
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- Llewellyn, David J. (författare)
- University of Exeter
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- Bennett, David A. (författare)
- Rush Alzheimer's Disease Center
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- Terracciano, Antonio (författare)
- Florida State University
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- Launer, Lenore (författare)
- National Institute on Aging, United States
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- Ladwig, Karl Heinz (författare)
- Helmholtz Zentrum München,German Center for Diabetes Research,Klinikum rechts der Isar
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- Cornelis, Marylin C. (författare)
- Northwestern University
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- Teumer, Alexander (författare)
- University of Greifswald
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- Grabe, Hans (författare)
- Helios Hanseklinikum Stralsund,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Kardia, Sharon L.R. (författare)
- University of Michigan
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- Ware, Erin B. (författare)
- University of Michigan
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- Smith, Jennifer A. (författare)
- University of Michigan
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- Snieder, Harold (författare)
- University of Groningen,University Medical Center Groningen
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- Eriksson, Johan G. (författare)
- Folkhälsan Research Center,University of Helsinki
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)
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- Räikkönen, Katri (författare)
- University of Helsinki
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- Lahti, Jari (författare)
- University of Helsinki
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(creator_code:org_t)
- 2018
- 2018
- Engelska 10 s.
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Ingår i: Psychosomatic Medicine. - 0033-3174. ; 80:3, s. 242-251
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits. Methods: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkage disequilibrium score regression by combining summary statistics of previously conducted meta-analyses for depressive symptoms by CHARGE consortium (N = 51,258), T2D by DIAGRAM consortium (N = 34,840 patients and 114,981 controls), fasting glucose, fasting insulin, and homeostatic model assessment of β-cell function and insulin resistance by MAGIC consortium (N = 58,074). Finally, we investigated pleiotropic loci using a bivariate genome-wide association study approach with summary statistics from genome-wide association study meta-analyses and reported loci with genome-wide significant bivariate association p value (p < 5 10−8). Biological annotation and function of significant pleiotropic SNPs were assessed in several databases. Results: The SNP-based heritability ranged from 0.04 to 0.10 in each individual trait. In the linkage disequilibrium score regression analyses, depressive symptoms showed no significant genetic correlation with T2D or glycemic traits (p > 0.37). However, we identified pleiotropic genetic variations for depressive symptoms and T2D (in the IGF2BP2, CDKAL1, CDKN2B-AS, and PLEKHA1 genes), and fasting glucose (in the MADD, CDKN2B-AS, PEX16, and MTNR1B genes). Conclusions: We found no significant overall genetic correlations between depressive symptoms, T2D, or glycemic traits suggesting major differences in underlying biology of these traits. However, several potential pleiotropic loci were identified between depressive symptoms, T2D, and fasting glucose, suggesting that previously established phenotypic associations may be partly explained by genetic variation in these specific loci.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Depression
- GWAS
- Meta-analysis
- Pleiotropy
- Type 2 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Haljas, Kadri
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Amare, Azmeraw T ...
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Alizadeh, Behroo ...
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Hsu, Yi Hsiang
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Mosley, Thomas
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Newman, Anne
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visa fler...
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Murabito, Joanne
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Tiemeier, Hennin ...
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Tanaka, Toshiko
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Van Duijn, Corne ...
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Ding, Jingzhong
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Llewellyn, David ...
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Bennett, David A ...
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Terracciano, Ant ...
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Launer, Lenore
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Ladwig, Karl Hei ...
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Cornelis, Maryli ...
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Teumer, Alexande ...
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Grabe, Hans
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Kardia, Sharon L ...
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Ware, Erin B.
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Smith, Jennifer ...
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Snieder, Harold
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Eriksson, Johan ...
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Groop, Leif
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Räikkönen, Katri
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Lahti, Jari
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MEDICIN OCH HÄLS ...
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och Endokrinologi oc ...
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Psychosomatic Me ...
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Lunds universitet