Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

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Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

Hoeft, Birgit (författare): German Cancer Research Center, Heidelberg, Germany

Linseisen, Jakob (författare): German Cancer Research Center, Heidelberg, Germany

Beckmann, Lars (författare): German Cancer Research Center, Heidelberg, Germany

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Mueller-Decker, Karin (författare): German Cancer Research Center, Heidelberg, Germany

Canzian, Federico (författare): German Cancer Research Center, Heidelberg, Germany

Huesing, Anika (författare): German Cancer Research Center, Heidelberg, Germany

Kaaks, Rudolf (författare): German Cancer Research Center, Heidelberg, Germany

Vogel, Ulla (författare): National Food Institute, Technical University of Denmark, Soborg, Denmark,National Research Centre for the Working Environment, Copenhagen, Denmark

Jakobsen, Marianne U. (författare): Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark

Overvad, Kim (författare): Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark

Hansen, Rikke D. (författare): Danish Cancer Society, Copenhagen, Denmark

Knueppel, Sven (författare): Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany

Boeing, Heiner (författare): Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany

Trichopoulou, Antonia (författare): Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece,Hellenic Health Foundation, Greece

Koumantaki, Yvoni (författare): Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece

Trichopoulos, Dimitrios (författare): Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA

Berrino, Franco (författare): Etiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy

Palli, Domenico (författare): Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy

Panico, Salvatore (författare): Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

Tumino, Rosario (författare): Cancer Registry and Histopathology Unit, Department of Oncology , “Civile - M.P.Arezzo” Hospital, Ragusa, Italy

Bueno-de-Mesquita, H. B. (författare): National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

van Duijnhoven, Franzel J. B. (författare): National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

van Gils, Carla H. (författare): Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands

Peeters, Petra H. (författare): Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

Dumeaux, Vanessa (författare): Institute of Community Medicine, University of Tromsø, Norway

Lund, Eiliv (författare): Institute of Community Medicine, University of Tromsø, Norway

Huerta Castano, Jose M. (författare): CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Council of Health and Consumer Affairs, Murcia, Spain

Munoz, Xavier (författare): Research Laboratory and Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain

Rodriguez, Laudina (författare): Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain

Barricarte, Aurelio (författare): CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Public Health Institute of Navarra, Pamplona, Spain

Manjer, Jonas (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Department of Surgery, Malmö University Hospital, Malmö, Sweden

Jirström, Karin (författare): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for Molecular Pathology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö Sweden,CREATE Health Center for Translational Cancer Research, Biomedical Center, Lund University, Lund, Sweden

Van Guelpen, Bethany (författare): Umeå universitet,Patologi

Hallmans, Göran, 1947- (författare): Umeå universitet,Näringsforskning

Spencer, Elizabeth A. (författare): Cancer Epidemiology Unit, University of Oxford, Oxford, UK

Crowe, Francesca L. (författare): Cancer Epidemiology Unit, University of Oxford, Oxford, UK

Khaw, Kay-Tee (författare): Department of Public Health and Primary Care, University of Cambridge

Wareham, Nick (författare): Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK

Morois, Sophie (författare): Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France

Boutron-Ruault, Marie-Christine (författare): Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France

Clavel-Chapelon, Francoise (författare): Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France

Chajes, Veronique (författare): International Agency for Research on Cancer (IARC), Lyon, France

Jenab, Mazda (författare): International Agency for Research on Cancer (IARC), Lyon, France

Boffetta, Paolo (författare): International Agency for Research on Cancer (IARC), Lyon, France

Vineis, Paolo (författare): Cancer Epidemiology Department, University of Turin, Turin, Italy,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

Mouw, Traci (författare): Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

Norat, Teresa (författare): Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

Riboli, Elio (författare): Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK

Nieters, Alexandra (författare): German Cancer Research Center, Heidelberg, Germany,Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany

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(creator_code:org_t)

2009-12-30
2010
Engelska.
Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 31:3, s. 466-472

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://academic.oup...; https://lup.lub.lu.s...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

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Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of > 5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whereas prostaglandin E receptor 2 (PTGER2) was associated with lower CRC risk. A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC. Based on these data, we present for the first time the association of HPGD variants with CRC risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk.

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Av författaren/redakt...: Hoeft, Birgit; Linseisen, Jakob; Beckmann, Lars; Mueller-Decker, ...; Canzian, Federic ...; Huesing, Anika; visa fler...; Kaaks, Rudolf; Vogel, Ulla; Jakobsen, Marian ...; Overvad, Kim; Hansen, Rikke D.; Knueppel, Sven; Boeing, Heiner; Trichopoulou, An ...; Koumantaki, Yvon ...; Trichopoulos, Di ...; Berrino, Franco; Palli, Domenico; Panico, Salvator ...; Tumino, Rosario; Bueno-de-Mesquit ...; van Duijnhoven, ...; van Gils, Carla ...; Peeters, Petra H ...; Dumeaux, Vanessa; Lund, Eiliv; Huerta Castano, ...; Munoz, Xavier; Rodriguez, Laudi ...; Barricarte, Aure ...; Manjer, Jonas; Jirström, Karin; Van Guelpen, Bet ...; Hallmans, Göran, ...; Spencer, Elizabe ...; Crowe, Francesca ...; Khaw, Kay-Tee; Wareham, Nick; Morois, Sophie; Boutron-Ruault, ...; Clavel-Chapelon, ...; Chajes, Veroniqu ...; Jenab, Mazda; Boffetta, Paolo; Vineis, Paolo; Mouw, Traci; Norat, Teresa; Riboli, Elio; Nieters, Alexand ...; visa färre...

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Artiklar i publikationen: Carcinogenesis

Av lärosätet: Lunds universitet; Umeå universitet

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Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

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