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Sökning: onr:"swepub:oai:lup.lub.lu.se:807b160f-c7f7-4b5b-8312-daed6102d9f8" > Prediagnostic alter...

Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

Stepien, Magdalena (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
Lopez-Nogueroles, Marina (författare)
CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
Lahoz, Agustin (författare)
CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
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Kühn, Tilman (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Perlemuter, Gabriel (författare)
INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,University of Paris-Saclay,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996)
Voican, Cosmin (författare)
INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay
Ciocan, Dragos (författare)
INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay
Boutron-Ruault, Marie Christine (författare)
Versailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
Jansen, Eugene (författare)
National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Viallon, Vivian (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
Leitzmann, Michael (författare)
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
Tjønneland, Anne (författare)
Diet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark
Severi, Gianluca (författare)
Versailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
Mancini, Francesca Romana (författare)
Institut Gustave Roussy,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
Dong, Catherine (författare)
Institut Gustave Roussy,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France; Department of Gastroenterology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Fortner, Renee Turzanski (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Bergmann, Manuela M. (författare)
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
Boeing, Heiner (författare)
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens, Greece
Karakatsani, Anna (författare)
Hellenic Health Foundation, Athens, Greece; 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Haidari, Greece,National and Kapodistrian University of Athens
Peppa, Eleni (författare)
Hellenic Health Foundation, Athens, Greece
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, Florence, Italy
Krogh, Vittorio (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milan, Italy
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital,Department of Cancer Registry and Histopathology, “M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Bueno-de-Mesquita, H. Bas (författare)
Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia,Imperial College London,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM)
Skeie, Guri (författare)
Department of Community Medicine, UIT—The Arctic University of Norway, Tromsø, Norway
Merino, Susana (författare)
Public Health Directorate, Asturias, Spain
Ros, Raul Zamora (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
Sánchez, Maria Jose (författare)
University of Granada,CIBER Epidemiology and Public Health (CIBERESP),Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Amiano, Pilar (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain,Biodonostia Health Research Institute
Huerta, Jose Mª (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Barricarte, Aurelio (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
Sjöberg, Klas (författare)
Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Gastroenterology and Nutrition, Lund University, Skåne University Hospital, Malmö, Sweden
Ohlsson, Bodil (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
Nyström, Hanna, 1980- (författare)
Umeå universitet,Umeå University,Kirurgi
Werner, Mårten (författare)
Umeå universitet,Umeå University,Avdelningen för medicin
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Schmidt, Julie A. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Freisling, Heinz (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
Scalbert, Augustin (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization,Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
Christakoudi, Sofia (författare)
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; MRC Centre for Transplantation, King's College London, London, United Kingdom,King's College London
Gunter, Marc J. (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
Jenab, Mazda (författare)
International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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 (creator_code:org_t)
2022-01-11
2022
Engelska 14 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 150:8, s. 1255-1268
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

bile acid metabolism
biomarkers
cancer prevention
hepatocellular carcinoma
obesity

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ref (ämneskategori)

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