Sökning: WFRF:(Huerta Jose M.) >
Prediagnostic alter...
Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Lopez-Nogueroles, Marina (författare)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
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- Lahoz, Agustin (författare)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Analytical Unit, Health Research Institute Hospital La Fe, Valencia, Spain
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- Kühn, Tilman (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Perlemuter, Gabriel (författare)
- INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Antoine-Béclère Hospital,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996)
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- Voican, Cosmin (författare)
- INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay
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- Ciocan, Dragos (författare)
- INSERM U996, Intestinal Microbiota, Macrophages and Liver Inflammation, DHU Hepatinov, Labex LERMIT, Clamart, France; Faculté de Médecine Paris-Sud, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay
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- Boutron-Ruault, Marie Christine (författare)
- Versailles Saint-Quentin-en-Yvelines University,Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Jansen, Eugene (författare)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Viallon, Vivian (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Leitzmann, Michael (författare)
- Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
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- Tjønneland, Anne (författare)
- Diet, Genes and Environment Unit, Danish Cancer Society Research Center, Copenhagen, Denmark
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- Severi, Gianluca (författare)
- Institut Gustave Roussy,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Mancini, Francesca Romana (författare)
- Institut Gustave Roussy,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Dong, Catherine (författare)
- Institut Gustave Roussy,CESP, Faculté de Médecine—Université Paris-Saclay, Faculté de Médecine—UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France; Department of Gastroenterology, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France,Versailles Saint-Quentin-en-Yvelines University
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Fortner, Renee Turzanski (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Bergmann, Manuela M. (författare)
- Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
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- Boeing, Heiner (författare)
- Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens, Greece
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- Karakatsani, Anna (författare)
- Hellenic Health Foundation, Athens, Greece; 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Haidari, Greece,Hellenic Health Foundation, Athens
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- Peppa, Eleni (författare)
- Hellenic Health Foundation, Athens, Greece
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network—ISPRO, Florence, Italy
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- Krogh, Vittorio (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Milan, Italy
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital,Department of Cancer Registry and Histopathology, “M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy
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- Sacerdote, Carlotta (författare)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
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- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Bueno-de-Mesquita, H. Bas (författare)
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia,University of Malaya,National Institute for Public Health and the Environment (RIVM),Imperial College London
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- Skeie, Guri (författare)
- Department of Community Medicine, UIT—The Arctic University of Norway, Tromsø, Norway
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- Merino, Susana (författare)
- Public Health Directorate, Asturias, Spain
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- Ros, Raul Zamora (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
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- Sánchez, Maria Jose (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP),Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Amiano, Pilar (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Huerta, Jose Mª (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Barricarte, Aurelio (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
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- Sjöberg, Klas (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Gastroenterology and Nutrition, Lund University, Skåne University Hospital, Malmö, Sweden
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
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- Nyström, Hanna, 1980- (författare)
- Umeå universitet,Umeå University,Kirurgi
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- Werner, Mårten (författare)
- Umeå universitet,Umeå University,Avdelningen för medicin
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Schmidt, Julie A. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization,Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Christakoudi, Sofia (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; MRC Centre for Transplantation, King's College London, London, United Kingdom,Imperial College London
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization,Nutrition and Metabolism Branch (NME), International Agency for Research on Cancer (IARC-WHO), Lyon, France
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(creator_code:org_t)
- 2022-01-11
- 2022
- Engelska 14 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 150:8, s. 1255-1268
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- bile acid metabolism
- biomarkers
- cancer prevention
- hepatocellular carcinoma
- obesity
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Stepien, Magdale ...
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Lopez-Nogueroles ...
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Lahoz, Agustin
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Kühn, Tilman
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Perlemuter, Gabr ...
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Voican, Cosmin
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visa fler...
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Ciocan, Dragos
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Boutron-Ruault, ...
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Jansen, Eugene
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Viallon, Vivian
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Leitzmann, Micha ...
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Tjønneland, Anne
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Severi, Gianluca
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Mancini, Frances ...
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Dong, Catherine
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Kaaks, Rudolf
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Fortner, Renee T ...
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Bergmann, Manuel ...
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Boeing, Heiner
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Peppa, Eleni
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Sacerdote, Carlo ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Skeie, Guri
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Merino, Susana
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Ros, Raul Zamora
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Sánchez, Maria J ...
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Amiano, Pilar
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Huerta, Jose Mª
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Barricarte, Aure ...
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Sjöberg, Klas
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Ohlsson, Bodil
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Nyström, Hanna, ...
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Werner, Mårten
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Perez-Cornago, A ...
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Schmidt, Julie A ...
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Freisling, Heinz
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Scalbert, August ...
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Weiderpass, Elis ...
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Christakoudi, So ...
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Gunter, Marc J.
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Jenab, Mazda
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