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Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Yeager, Meredith (author)
Chatterjee, Nilanjan (author)
Ciampa, Julia (author)
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Jacobs, Kevin B (author)
Gonzalez-Bosquet, Jesus (author)
Hayes, Richard B (author)
Kraft, Peter (author)
Wacholder, Sholom (author)
Orr, Nick (author)
Berndt, Sonja (author)
Yu, Kai (author)
Hutchinson, Amy (author)
Wang, Zhaoming (author)
Amundadottir, Laufey (author)
Feigelson, Heather Spencer (author)
Thun, Michael J (author)
Diver, W Ryan (author)
Albanes, Demetrius (author)
Virtamo, Jarmo (author)
Weinstein, Stephanie (author)
Schumacher, Fredrick R (author)
Cancel-Tassin, Geraldine (author)
Cussenot, Olivier (author)
Valeri, Antoine (author)
Andriole, Gerald L (author)
Crawford, E David (author)
Haiman, Christopher A (author)
Henderson, Brian (author)
Kolonel, Laurence (author)
Le Marchand, Loic (author)
Siddiq, Afshan (author)
Riboli, Elio (author)
Key, Timothy J (author)
Kaaks, Rudolf (author)
Isaacs, William (author)
Isaacs, Sarah (author)
Wiley, Kathleen E (author)
Gronberg, Henrik (author)
Karolinska Institutet
Wiklund, Fredrik (author)
Karolinska Institutet
Stattin, Pär (author)
Umeå universitet,Urologi och andrologi
Xu, Jianfeng (author)
Zheng, S Lilly (author)
Sun, Jielin (author)
Vatten, Lars J (author)
Hveem, Kristian (author)
Kumle, Merethe (author)
Tucker, Margaret (author)
Gerhard, Daniela S (author)
Hoover, Robert N (author)
Fraumeni, Joseph F (author)
Hunter, David J (author)
Thomas, Gilles (author)
Chanock, Stephen J (author)
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 (creator_code:org_t)
2009-09-20
2009
English.
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:10, s. 1055-7
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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