Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

• Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

electrophoresis

2D

proteomics

neuroinflammation

Huntington's disease

plasma

LC/MS/MS

MALDI-TOF

ELISA

biomarkers

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)