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Impact of discordan...
Impact of discordance between patient's and evaluator's global assessment on treatment outcomes in 14 868 patients with spondyloarthritis
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Michelsen, B. (author)
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Ornbjerg, L. M. (author)
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Kvien, T. K. (author)
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show more...
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Pavelka, K. (author)
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Nissen, M. J. (author)
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Nordstrom, D. (author)
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Santos, M. J. (author)
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Koca, S. S. (author)
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- Askling, J. (author)
- Karolinska Institutet
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Rotar, Z. (author)
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Gudbjornsson, B. (author)
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Codreanu, C. (author)
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Loft, A. G. (author)
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Kristianslund, E. K. (author)
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Mann, H. F. (author)
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Ciurea, A. (author)
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Eklund, K. K. (author)
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Vieira-Sousa, E. (author)
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Yazici, A. (author)
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- Jacobsson, Lennart T. H., 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Tomsic, M. (author)
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Love, T. J. (author)
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Ionescu, R. (author)
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van der Horst-Bruinsma, I. E. (author)
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Iannone, F. (author)
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Pombo-Suarez, M. (author)
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Jones, G. T. (author)
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Hyldstrup, L. H. (author)
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Krogh, N. S. (author)
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Hetland, M. L. (author)
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Ostergaard, M. (author)
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(creator_code:org_t)
- 2020-01-20
- 2020
- English.
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In: Rheumatology. - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 59:9, s. 2455-2461
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives. To assess the impact of 'patient's minus evaluator's global assessment of disease activity' (Delta PEG) at treatment initiation on retention and remission rates of TNF inhibitors (TNFi) in psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) patients across Europe. Methods. Real-life data from PsA and axSpA patients starting their first TNFi from 11 countries in the European Spondyloarthritis Research Collaboration Network were pooled. Retention rates were compared by Kaplan-Meier analyses with log-rank test and by Cox regression, and remission rates by chi(2) test and by logistic regression across quartiles of baseline Delta PEG, separately in female and male PsA and axSpA patients. Results. We included 14 868 spondyloarthritis (5855 PsA, 9013 axSpA) patients. Baseline Delta PEG was negatively associated with 6/12/24-months' TNFi retention rates in female and male PsA and axSpA patients (P < 0.001), with 6/12/24-months' BASDAI < 2 (P <= 0.002) and ASDAS < 1.3 (P <= 0.005) in axSpA patients, and with DAS28CRP(4)<2.6 (P <= 0.04) and DAPSA28 <= 4 (P <= 0.01), but not DAS28CRP(3)<2.6 (P >= 0.13) in PsA patients, with few exceptions on remission rates. Retention and remission rates were overall lower in female than male patients. Conclusion. High baseline patient's compared with evaluator's global assessment was associated with lower 6/12/24-months' remission as well as retention rates of first TNFi in both PsA and axSpA patients. These results highlight the importance of discordance between patient's and evaluator's perspective on disease outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- axial spondyloarthritis
- psoriatic arthritis
- TNF inhibitors
- treatment
- outcomes
- psoriatic-arthritis
- physician
- Rheumatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Michelsen, B.
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Ornbjerg, L. M.
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Kvien, T. K.
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Pavelka, K.
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Nissen, M. J.
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Nordstrom, D.
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show more...
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Santos, M. J.
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Koca, S. S.
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Askling, J.
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Rotar, Z.
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Gudbjornsson, B.
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Codreanu, C.
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Loft, A. G.
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Kristianslund, E ...
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Mann, H. F.
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Ciurea, A.
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Eklund, K. K.
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Vieira-Sousa, E.
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Yazici, A.
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Jacobsson, Lenna ...
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Tomsic, M.
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Love, T. J.
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Ionescu, R.
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van der Horst-Br ...
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Iannone, F.
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Pombo-Suarez, M.
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Jones, G. T.
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Hyldstrup, L. H.
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Krogh, N. S.
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Hetland, M. L.
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Ostergaard, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Rheumatology
- By the university
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University of Gothenburg
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Karolinska Institutet