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An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells

Bergqvist, Cecilia (author)
Stockholms universitet,Institutionen för neurokemi
Jafferali, Mohammed Hakim (author)
Stockholms universitet,Institutionen för neurokemi
Gudise, Santhosh (author)
Stockholms universitet,Institutionen för neurokemi
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Markus, Robert (author)
Stockholms universitet,Institutionen för neurokemi
Hallberg, Einar (author)
Stockholms universitet,Institutionen för neurokemi
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 (creator_code:org_t)
Elsevier BV, 2017
2017
English.
In: Stem Cell Research. - : Elsevier BV. - 1873-5061 .- 1876-7753. ; 23, s. 33-38
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The ability of iPSCs (induced pluripotent stem cells) to generate any cell type in the body makes them valuable tools for cell replacement therapies. However, differentiation of iPSCs can be demanding, slowand variable. During differentiation chromatin is re-organized and silent dense heterochromatin becomes tethered to the nuclear periphery by processes involving the nuclear lamina and proteins of the INM(inner nuclearmembrane). The INM protein, Samp1 (Spindle AssociatedMembrane Protein 1) interacts with Lamin A/C and the INMprotein Emerin, which has a chromatin binding LEM(Lap2-Emerin-Man1)-domain. In this paperweinvestigate if Samp1 can play a role in the differentiation of iPSCs. Samp1 levels increased as differentiating iPSCs started to express Lamin A/C. Interestingly, even under pluripotent culturing conditions, ectopic expression of Samp1 induced a rapid differentiation of iPSCs, ofwhich some expressed the neuronal marker beta III-tubulin already after 6 days. This suggests that Samp1 is involved in early differentiation of iPSCs and could potentially be explored as a tool to promote progression of the differentiation process.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Miljöbioteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Environmental Biotechnology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

Keyword

Nuclear membrane
Nuclear envelope
Induced pluripotent stem cells
Neuronal differentiation
Regenerative medicine

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Bergqvist, Cecil ...
Jafferali, Moham ...
Gudise, Santhosh
Markus, Robert
Hallberg, Einar
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ENGINEERING AND TECHNOLOGY
ENGINEERING AND ...
and Medical Engineer ...
ENGINEERING AND TECHNOLOGY
ENGINEERING AND ...
and Environmental Bi ...
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Cell Biology
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Stem Cell Resear ...
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Stockholm University

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