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Cardiovascular dise...
Cardiovascular disease and subsequent risk of psychiatric disorders : a nationwide sibling-controlled study
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- Shen, Qing (författare)
- Karolinska Institutet
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- Song, Huan (författare)
- West China Biomedical Big Data Center, Sichuan University, Chengdu, China
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- Aspelund, Thor (författare)
- Faculty of Medicine, University of Iceland, Reykjavík, Iceland
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- Yu, Jingru (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
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- Lu, Donghao (författare)
- Karolinska Institutet
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- Jakobsdóttir, Jóhanna (författare)
- Karolinska Institutet
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- Bergstedt, Jacob (författare)
- Unit of Integrative Epidemiology, Karolinska Institute, Stockholm, Sweden
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- Yi, Lu (författare)
- Karolinska Institutet
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- Sullivan, Patrick (författare)
- Karolinska Institutet
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- Sjölander, Arvid (författare)
- Karolinska Institutet
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- Ye, Weimin (författare)
- Karolinska Institutet
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, Örebro University, Örebro, Sweden
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- Fang, Fang (författare)
- Karolinska Institutet
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- Valdimarsdóttir, Unnur (författare)
- Karolinska Institutet
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(creator_code:org_t)
- eLife Sciences Publications Ltd, 2022
- 2022
- Engelska.
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 11
- Relaterad länk:
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https://doi.org/10.7...
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The association between cardiovascular disease (CVD) and selected psychiatric disorders has frequently been suggested while the potential role of familial factors and comorbidities in such association has rarely been investigated.Methods: We identified 869 056 patients newly diagnosed with CVD from 1987 to 2016 in Sweden with no history of psychiatric disorders, and 910 178 full siblings of these patients as well as 10 individually age- and sex-matched unrelated population controls (N=8 690 560). Adjusting for multiple comorbid conditions, we used flexible parametric models and Cox models to estimate the association of CVD with risk of all subsequent psychiatric disorders, comparing rates of first incident psychiatric disorder among CVD patients with rates among unaffected full siblings and population controls.Results: The median age at diagnosis was 60 years for patients with CVD and 59.2% were male. During up to thirty years of follow-up, the crude incidence rates of psychiatric disorder were 7.1, 4.6 and 4.0 per 1000 person-years for patients with CVD, their siblings and population controls. In the sibling comparison, we observed an increased risk of psychiatric disorder during the first year after CVD diagnosis (hazard ratio [HR], 2.74; 95% confidence interval [CI], 2.62-2.87) and thereafter (1.45; 95% CI, 1.42-1.48). Increased risks were observed for all types of psychiatric disorders and among all diagnoses of CVD. We observed similar associations in the population comparison. CVD patients who developed a comorbid psychiatric disorder during the first year after diagnosis were at elevated risk of subsequent CVD death compared to patients without such comorbidity (HR 1.55; 95% CI 1.44-1.67).Conclusions: Patients diagnosed with CVD are at an elevated risk for subsequent psychiatric disorders independent of shared familial factors and comorbid conditions. Comorbid psychiatric disorders in patients with CVD are associated with higher risk of cardiovascular mortality suggesting that surveillance and treatment of psychiatric comorbidities should be considered as an integral part of clinical management of newly diagnosed CVD patients.Funding: This work was supported by the EU Horizon 2020 Research and Innovation Action Grant (CoMorMent, grant no. 847776 to UV, PFS and FF), Grant of Excellence, Icelandic Research Fund (grant no. 163362-051 to UV), ERC Consolidator Grant (StressGene, grant no: 726413 to UV), Swedish Research Council (grant no. D0886501 to PFS) and US NIMH R01 MH123724 (to PFS).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Epidemiology
- global health
- human
- medicine
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Shen, Qing
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Song, Huan
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Aspelund, Thor
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Yu, Jingru
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Lu, Donghao
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Jakobsdóttir, Jó ...
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Bergstedt, Jacob
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Yi, Lu
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Sullivan, Patric ...
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Sjölander, Arvid
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Ye, Weimin
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Fall, Katja, 197 ...
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Fang, Fang
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Valdimarsdóttir, ...
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