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Sökning: onr:"swepub:oai:DiVA.org:mau-53857" > Influence of Geneti...

Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study) : the protocol for a Copenhagen IBD Inception Cohort Study

Attauabi, Mohamed (författare)
Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark
Madsen, Gorm Roager (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark
Bendtsen, Flemming (författare)
Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark
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Wewer, Anne Vibeke (författare)
The Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark
Wilkens, Rune (författare)
Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark
Ilvemark, Johan (författare)
Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark
Vladimirova, Nora (författare)
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark
Jensen, Annette Bøjer (författare)
Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark
Jensen, Frank Krieger (författare)
Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark
Hansen, Sanja Bay (författare)
Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark
Siebner, Hartwig Roman (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark
Nielsen, Yousef Jesper Wirenfeldt (författare)
Department of Radiology, Herlev Hospital, Herlev, Denmark
Møller, Jakob M (författare)
Department of Radiology, Herlev Hospital, Herlev, Denmark
Thomsen, Henrik S (författare)
Department of Radiology, Herlev Hospital, Herlev, Denmark
Thomsen, Simon Francis (författare)
Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark
Ingels, Helene Andrea Sinclair (författare)
Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Kobenhavn, Denmark
Theede, Klaus (författare)
Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark
Boysen, Trine (författare)
Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark
Bjerrum, Jacob T (författare)
Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark
Jakobsen, Christian (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark
Dorn-Rasmussen, Maria (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark
Jansson, Sabine (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark
Yao, Yiqiu (författare)
Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark
Burian, Ewa Anna (författare)
Department of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark
Møller, Frederik Trier (författare)
Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Kobenhavn, Denmark
Fana, Viktoria (författare)
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark
Wiell, Charlotte (författare)
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark
Terslev, Lene (författare)
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Glostrup, Denmark
Østergaard, Mikkel (författare)
Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark
Bertl, Kristina (författare)
Malmö universitet,Odontologiska fakulteten (OD),Periodontology
Stavropoulos, Andreas (författare)
Malmö universitet,Odontologiska fakulteten (OD),Periodontology
Seidelin, Jakob B (författare)
Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark
Burisch, Johan (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark
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 (creator_code:org_t)
2022-06-27
2022
Engelska.
Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 12:6, s. e055779-e055779
Relaterad länk:
https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Introduction: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.Methods and analysis: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

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