SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-356495"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-356495" > Genome-wide associa...

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids : Results from the CHARGE Consortium

Otto, Marcia C. de Oliveira (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA
Lemaitre, Rozenn N. (författare)
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Sun, Qi (författare)
Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
visa fler...
King, Irena B. (författare)
Univ New Mexico, Albuquerque, NM USA
Wu, Jason H. Y. (författare)
Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; Univ New South Wales, Fac Med, Sydney, NSW, Australia
Manichaikul, Ani (författare)
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Rich, Stephen S. (författare)
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
Tsai, Michael Y. (författare)
Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA
Chen, Y. D. (författare)
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA USA
Fornage, Myriam (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Key Lab Nutr & Metab, Houston, TX USA
Weihua, Guan (författare)
Univ Minnesota, Dept Biostat, Minneapolis, MN USA
Aslibekyan, Stella (författare)
Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
Irvin, Marguerite R. (författare)
Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
Kabagambe, Edmond K. (författare)
Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
Arnett, Donna K. (författare)
Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
Jensen, Majken K. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA;Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Boston, MA USA
McKnight, Barbara (författare)
Univ Washington, Dept Biostat, Seattle, WA USA
Psaty, Bruce M. (författare)
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
Steffen, Lyn M. (författare)
Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
Smith, Caren E. (författare)
Tufts Univ, Jean Mayer USDA HNRCA, Nutr & Genom Lab, Boston, MA USA
Risérus, Ulf, 1967- (författare)
Uppsala universitet,Klinisk nutrition och metabolism
Lind, Lars (författare)
Uppsala universitet,Kardiovaskulär epidemiologi
Hu, Frank B. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
Rimm, Eric B. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
Siscovick, David S. (författare)
New York Acad Med, New York, NY USA
Mozaffarian, Dariush (författare)
Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA
visa färre...
 (creator_code:org_t)
2018-05-08
2018
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:5
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://uu.diva-port... (primary) (Raw object)
https://journals.plo...
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy