Sökning: WFRF:(Jerkeman Mats) >
Lenalidomide-bendam...
Lenalidomide-bendamustine-rituximab in patients older than 65 years with untreated mantle cell lymphoma
-
- Albertsson-Lindblad, Alexandra (författare)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
-
- Kolstad, Arne (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
-
- Laurell, Anna (författare)
- Univ Uppsala Hosp, Dept Oncol, Uppsala, Sweden.
-
visa fler...
-
- Raty, Riikka (författare)
- Helsinki Univ Hosp, Dept Hematol, Helsinki, Finland.
-
- Gronbaek, Kirsten (författare)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
-
- Sundberg, Jan (författare)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
-
- Pedersen, Lone Bredo (författare)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
-
- Ralfkiaer, Elisabeth (författare)
- Rigshosp, Dept Pathol, Copenhagen, Denmark.
-
- Karjalainen-Lindsberg, Marja-Liisa (författare)
- Univ Helsinki, Cent Hosp, Dept Pathol, Helsinki, Finland.
-
- Sundström, Christer (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Department of Pathology, Uppsala University Hospital, Uppsala, Sweden; and.,Rose-Marie Amini
-
- Ehinger, Mats (författare)
- Univ Lund Hosp, Dept Pathol Cytol, Lund, Sweden.
-
- Geisler, Christian (författare)
- Rigshosp, Dept Hematol, Copenhagen, Denmark.
-
- Jerkeman, Mats (författare)
- Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden.
-
visa färre...
-
Skane Univ Hosp, Dept Oncol, SE-22185 Lund, Sweden Oslo Univ Hosp, Dept Oncol, Oslo, Norway. (creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- Engelska.
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 128:14, s. 1814-1820
- Relaterad länk:
-
https://ashpublicati...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- For elderly patients with mantle cell lymphoma (MCL), there is no defined standard therapy. In this multicenter, open-label phase 1/2 trial, we evaluated the addition of lenalidomide (LEN) to rituximab-bendamustine (R-B) as first-line treatment for elderly patients with MCL. Patients >65 years with untreated MCL, stages II-IV were eligible for inclusion. Primary end points were maximally tolerable dose (MTD) of LEN and progression-free survival (PFS). Patients received 6 cycles every four weeks of L-B-R (L D1-14, B 90 mg/m(2) IV, days 1-2 and R 375 mg/m(2) IV, day 1) followed by single LEN (days 1-21, every four weeks, cycles 7-13). Fifty-one patients (median age 71 years) were enrolled from 2009 to 2013. In phase 1, the MTD of LEN was defined as 10 mg in cycles 2 through 6, and omitted in cycle 1. After 6 cycles, the complete remission rate (CRR) was 64%, and 36% were MRD negative. At a median follow-up time of 31 months, median PFS was 42 months and 3-year overall survival was 73%. Infection was the most common nonhematologic grade 3 to 5 event and occurred in 21 (42%) patients. Opportunistic infections occurred in 3 patients: 2 Pneumocystis carinii pneumonia and 1 cytomegalovirus retinitis. Second primary malignancies (SPM) were observed in 8 patients (16%). LEN could safely be combined with R-B when added from the second cycle in patients with MCL, and was associated with a high rate of CR and molecular remission. However, we observed a high degree of severe infections and an unexpected high number of SPMs, which may limit its use. This trial is registered at www.Clinicaltrials.gov as #NCT00963534.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Patologi
- Pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Blood
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Albertsson-Lindb ...
-
Kolstad, Arne
-
Laurell, Anna
-
Raty, Riikka
-
Gronbaek, Kirste ...
-
Sundberg, Jan
-
visa fler...
-
Pedersen, Lone B ...
-
Ralfkiaer, Elisa ...
-
Karjalainen-Lind ...
-
Sundström, Chris ...
-
Ehinger, Mats
-
Geisler, Christi ...
-
Jerkeman, Mats
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Klinisk laborato ...
- Artiklar i publikationen
-
Blood
- Av lärosätet
-
Uppsala universitet