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Sökning: onr:"swepub:oai:DiVA.org:umu-215721" > Experimental phasin...

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths

El Omari, Kamel (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
Duman, Ramona (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
Mykhaylyk, Vitaliy (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
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Orr, Christian M. (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
Latimer-Smith, Merlyn (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom
Winter, Graeme (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom
Grama, Vinay (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom
Qu, Feng (författare)
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom; Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Bountra, Kiran (författare)
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom
Kwong, Hok Sau (författare)
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom
Romano, Maria (författare)
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom; Institute of Biostructures and Bioimaging, IBB, CNR, Naples, Italy; Department of Pharmacy, University of Naples “Federico II”, Naples, Italy
Reis, Rosana I. (författare)
National Physical Laboratory, Hampton Road, Teddington, United Kingdom
Vogeley, Lutz (författare)
Charles River Discovery Research Services UK, Chesterford Research Park, Saffron Walden, United Kingdom; Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany
Vecchia, Luca (författare)
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Owen, C. David (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
Wittmann, Sina (författare)
Department of Biochemistry, University of Oxford, Oxford, United Kingdom; Institute of Molecular Biology (IMB), Ackermannweg 4, Mainz, Germany
Renner, Max (författare)
Umeå universitet,Kemiska institutionen,Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Senda, Miki (författare)
Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Ibaraki, Tsukuba, Japan
Matsugaki, Naohiro (författare)
Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Ibaraki, Tsukuba, Japan; Department of Materials Structure Science, School of High Energy Accelerator Science, The Graduate University of Advanced Studies (Soken-dai), 1-1 Oho, Ibaraki, Tsukuba, Japan
Kawano, Yoshiaki (författare)
Advanced Photon Technology Division, RIKEN SPring-8 Center, Hyogo, Japan
Bowden, Thomas A. (författare)
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Moraes, Isabel (författare)
National Physical Laboratory, Hampton Road, Teddington, United Kingdom
Grimes, Jonathan M. (författare)
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Mancini, Erika J. (författare)
School of Life Sciences, University of Sussex, Falmer, Brighton, United Kingdom
Walsh, Martin A. (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
Guzzo, Cristiane R. (författare)
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
Owens, Raymond J. (författare)
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; The Rosalind Franklin Institute, Harwell Campus, Oxford, United Kingdom
Jones, E. Yvonne (författare)
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Brown, David G. (författare)
Charles River Discovery Research Services UK, Chesterford Research Park, Saffron Walden, United Kingdom
Stuart, Dave I. (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Beis, Konstantinos (författare)
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom; Department of Life Sciences, Imperial College London, London, United Kingdom
Wagner, Armin (författare)
Diamond Light Source, Harwell Science and Innovation Campus, United Kingdom; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom
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 (creator_code:org_t)
Nature Publishing Group, 2023
2023
Engelska.
Ingår i: Communications Chemistry. - : Nature Publishing Group. - 2399-3669. ; 6:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by means of single-wavelength anomalous diffraction (SAD) techniques. Most synchrotron beamlines provide highly brilliant beams of X-rays of between 0.7 and 2 Å wavelength. Use of longer wavelengths to access the absorption edges of biologically important lighter atoms such as calcium, potassium, chlorine, sulfur and phosphorus for native-SAD phasing is attractive but technically highly challenging. The long-wavelength beamline I23 at Diamond Light Source overcomes these limitations and extends the accessible wavelength range to λ = 5.9 Å. Here we report 22 macromolecular structures solved in this extended wavelength range, using anomalous scattering from a range of elements which demonstrate the routine feasibility of lighter atom phasing. We suggest that, in light of its advantages, long-wavelength crystallography is a compelling option for experimental phasing.

Ämnesord

NATURVETENSKAP  -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)

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